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Study reveals how a stubborn lung infection evolves inside patients over years

Researchers at Trinity Translational Medicine Institute (TTMI) and the Irish Mycobacterial Reference Laboratory at St James’s Hospital have uncovered how the bacterium Mycobacterium avium—a leading cause of difficult-to-treat chronic lung infections—changes and adapts inside patients over many years of illness.

Their findings, published in the journal Genome Medicine, could help doctors understand why M. avium infections come back and why antibiotics sometimes fail.

The team undertook this research to understand how M. avium manages to survive for years in people’s lungs, even during long courses of antibiotics. This bacterium causes a type of chronic lung that’s becoming more common around the world.

How the brain’s activity, energy use and blood flow change as people fall asleep

A new study by investigators from Mass General Brigham has used next-generation imaging technology to discover that when the brain is falling asleep, it shows a coordinated shift in activity.

The researchers found that during NREM (non-rapid eye movement) , parts of the brain that handle movement and stay active and keep using energy, while areas involved in thinking, memory and daydreaming quiet down and use less energy. Their results are published in Nature Communications.

“This research helps explain how the brain stays responsive to the outside world even as awareness fades during sleep,” said corresponding author Jingyuan Chen, Ph.D., an assistant investigator at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital.

The Neuroscience Behind Writing: Handwriting vs. Typing—Who Wins the Battle?

Writing is a complex phenomenon that requires diverse skills: perceiving the pen and paper, moving the writing instrument, and directing the movement through thought. Using a pen involves paying attention to motor aspects such as drawing letters legibly, controlling the pressure of the tip on the paper, following lines and spaces on the page, and coordinating thought, action, and vision. This multisensory integration underlies memory abilities. Moreover, handwriting involves a wide variety of supporting materials, including pens, pencils, or chalk on a blackboard, all of which offer different experiences and create new neural activations and skills.

Despite sharing similar central goals and processes, handwriting and typing differ significantly in terms of the tools used, spatiotemporal dimensions, motor programming, and fine motor development. Compared with handwriting, which requires more time and attention to learn, typing can be considered simpler and faster, as it enables the production of a more easily readable and homogeneous product in less time. However, focused attention and a longer processing time improve memory retention, and once automatic control of the graphic gesture is achieved, minimal cognitive effort is required. Moreover, the specific movements memorized when learning to write contribute to the visual recognition of graphic shapes and letters and secondarily also improve reading ability. Indeed, since the ability to recognize letters is widely recognized in the literature as the first phase of reading, improving it through writing may effectively influence how children read.

The comparison between handwriting and typing reveals important differences in their neural and cognitive impacts. Handwriting activates a broader network of brain regions involved in motor, sensory, and cognitive processing, contributing to deeper learning, enhanced memory retention, and more effective engagement with written material. Typing, while more efficient and automated, engages fewer neural circuits, resulting in more passive cognitive engagement. These findings suggest that despite the advantages of typing in terms of speed and convenience, handwriting remains an important tool for learning and memory retention, particularly in educational contexts.

Music of the Spheres and the Lessons of Pythagoras

I. Using simple mathematics, Pythagoras was able to describe the basis of almost all musical scales, including the pentatonic, the Western, the chromatic and the Arabic scales. This shows the power and excitement of science. For the first time, Pythagoras could answer the question, WHY? Why are these notes and scales special? The answer is that they are formed in a simple, systematic, and mathematical manner. Most importantly, Pythagoras showed that the notes are not random or arbitrary and that they could be understood on a deeper level.

II. Pythagorass discoveries bring up a deeper psychology question: scales were first developed by ear: we and the Neanderthals choose these particular notes before there was any understanding of mathematics or physics. The notes were chosen simply because they were pleasing to the ear. But, as it turns out, the scales also follow basic mathematical constructs. So the question is, what does this say about our likes and emotions? Is there a mathematical/physical basis to them, as well?

III. The power of spectroscopy. What Pythagoras did was look a physical system (the musical scale), found characteristic frequencies (pitches/notes) and found simple mathematical relationships between the frequencies (ratios of 3/2, for example). This process actually became a fundamental part of physics, and modern physics, in particular.

The changing landscape of primary autoimmune neuropathies

Management of autoimmune neuropathies has remained unchanged for much of the past 30 years, but recent advances are changing the rate of progress. In this Review, the authors summarize the latest developments, including discoveries in disease mechanisms, new diagnostic guidelines, identification of new biomarkers and the status of promising clinical trials.

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