Aug 5, 2021
Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
Posted by Saúl Morales Rodriguéz in categories: bioengineering, biotech/medical
Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties that regulate angiogenesis.