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Mar 16, 2020

Mazda Supercar Rendering Imagines A Japanese Mid-Engine Beauty

Posted by in category: futurism

There are only a few Japanese mid-engine supercars that have existed, but if Mazda were to make one, it would probably look like this.

Mar 16, 2020

Brain-doping produced by your own body

Posted by in categories: biotech/medical, neuroscience

Erythropoietin, or Epo for short, is a notorious doping agent. It promotes the formation of red blood cells, leading thereby to enhanced physical performance — at least, that is what we have believed until now. However, as a growth factor, it also protects and regenerates nerve cells in the brain. Researchers at the Max Planck Institute of Experimental Medicine in Göttingen have now revealed how Epo achieves this effect. They have discovered that cognitive challenges trigger a slight oxygen deficit (termed ‘functional hypoxia’ by the researchers) in the brain’s nerve cells. This increases production of Epo and its receptors in the active nerve cells, stimulating neighbouring precursor cells to form new nerve cells and causing the nerve cells to connect to one another more effectively.

The growth factor erythropoietin is among others responsible for stimulating the production of red blood cells. In anaemia patients it promotes blood formation. It is also a highly potent substance used for illegal performance enhancement in sports.

“Administering Epo improves regeneration after a stroke (termed ‘neuroprotection’ or ‘neurogeneration’), reducing damage in the brain. Patients with mental health disorders such as schizophrenia, depression, bipolar disorder or multiple sclerosis who have been treated with Epo have shown a significant improvement in cognitive performance,” says Hannelore Ehrenreich of the Max Planck Institute of Experimental Medicine. Along with her colleagues, she has spent many years researching the role played by Epo in the brain.

Mar 16, 2020

Since my Harvard lab closed yesterday, I’ve been reading and interpreting this week’s published papers on #COVID19

Posted by in category: biotech/medical

What follows is a thread of information, my interpretation, links to sources & predictions. Let’s start with what you need to know… #coronavirus #COVIDー19

Mar 16, 2020

The golden age of neutron-star physics has arrived

Posted by in categories: particle physics, space

Astronomers know that much about how neutron stars are born. Yet exactly what happens afterwards, inside these ultra-dense cores, remains a mystery. Some researchers theorize that neutrons might dominate all the way down to the centre. Others hypothesize that the incredible pressure compacts the material into more exotic particles or states that squish and deform in unusual ways.

Now, after decades of speculation, researchers are getting closer to solving the enigma, in part thanks to an instrument on the International Space Station called the Neutron Star Interior Composition Explorer (NICER).

These stellar remnants are some of the Universe’s most enigmatic objects — and they are finally starting to give up their secrets.

Mar 16, 2020

Scientists can now edit multiple genome fragments at a time

Posted by in categories: biotech/medical, genetics, health

Scientists can now edit multiple sites in the genome at the same time to learn how different DNA stretches co-operate in health and disease.

CRISPR-based DNA editing has revolutionized the study of the human genome by allowing precise deletion of any human gene to glean insights into its function. But one feature remained challenging—the ability to simultaneously remove multiple genes or gene fragments in the same cell. Yet this type of genome surgery is key for scientists to understand how different parts of the genome work together in the contexts of both normal physiology and disease.

Now such a tool exists thanks to the teams of Benjamin Blencowe and Jason Moffat, both professors of molecular genetics at the Donnelly Centre for Cellular and Biomolecular Research. Dubbed ‘CHyMErA’, for Cas Hybrid for Multiplexed Editing and Screening Applications, the method can be applied to any type of mammalian cell to systematically target the DNA at multiple positions at the same time, as described in a study published in the journal Nature Biotechnology.

Mar 16, 2020

To Turbocharge Anti-Aging Treatment, Just Add… a Protein Found in Fruit Flies?

Posted by in categories: biotech/medical, life extension

Because of the central importance of tissue repair to all organisms, Neves assumed that many of the mechanisms behind it would be shared among all animals. So she started looking at proteins produced by immune cells in the well-known animal model of the fruit fly.

She discovered that a poorly-understood protein known as MANF (mesencephalic astrocyte-derived neurotrophic factor) plays a crucial role in reducing inflammation in fruit flies. More importantly, she found that mice and humans also produce it, and its prevalence reduces in all the species as they age, suggesting it plays a key role in limiting age-related inflammation.

That prompted her to see if introducing MANF would boost the effectiveness of stem cell treatments in older animals. She used the protein in combination with a procedure that uses stem cells to replace degenerating photoreceptors in the retina of older mice and found it greatly improved the restoration of vision.

Mar 16, 2020

A trick from cancer cells helps rats accept transplanted limbs

Posted by in categories: biotech/medical, education

Ogba Educational Clinic

Rats that received microparticles that release a chemical signal to recruit immune cells tolerated hind limb transplants for more than 200 days.

Mar 16, 2020

Special Report: Coronavirus Task Force Holds News Conference | NBC News (Live Stream)

Posted by in categories: biotech/medical, innovation

The US is going to lockdown for 15 days to start.

Members of the Trump administration’s coronavirus task force, led by Vice President Mike Pence, hold a press briefing at the White House.
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Mar 16, 2020

Google becomes third U.S. tech company worth $1 trillion

Posted by in category: futurism

Google’s parent company became the third tech company to reach a $1 trillion market capitalization Thursday, joining Apple Inc. and Microsoft Corp.

Mar 16, 2020

A new theory of magnetar formation

Posted by in categories: computing, space

Magnetars are neutron stars endowed with the strongest magnetic fields observed in the universe, but their origin remains controversial. In a study published in Science Advances, a team of scientists from CEA, Saclay, the Max Planck Institute for Astrophysics (MPA), and the Institut de Physique du Globe de Paris developed a new and unprecedentedly detailed computer model that can explain the genesis of these gigantic fields through the amplification of pre-existing weak fields when rapidly rotating neutron stars are born in collapsing massive stars. The work opens new avenues to understand the most powerful and most luminous explosions of such stars.

Magnetars: what are they?

Neutron stars are compact objects containing one to two within a radius of about 12 kilometers. Among them, magnetars are characterized by eruptive emission of X-rays and gamma rays. The energy associated with these bursts of intense radiation is probably related to ultra–. Magnetars should thus spin down faster than other neutron stars due to enhanced magnetic braking, and measurements of their rotation period evolution have confirmed this scenario. We thus infer that magnetars have a dipole magnetic field of the order of 1015 Gauss (G), i.e., up to 1000 times stronger than typical neutron stars! While the existence of these tremendous magnetic fields is now well established, their origin remains controversial.