Lifeboat Foundation

Chimeric antigen receptor (CAR) T cells have emerged as a promising treatment for patients with advanced B-cell cancers. However, widespread application of the therapy is currently limited by potentially life-threatening toxicities due to a lack of control of the highly potent transfused cells. Researchers have therefore developed several regulatory mechanisms in order to control CAR T cells in vivo. Clinical adoption of these control systems will depend on several factors, including the need for temporal and spatial control, the immunogenicity of the requisite components as well as whether the system allows reversible control or induces permanent elimination. Here we describe currently available and emerging control methods and review their function, advantages, and limitations.

As a living drug, CAR T cells bear the potential for rapid and massive activation and proliferation, which contributes to their therapeutic efficacy but simultaneously underlies the side effects associated with CAR T-cell therapy. The most well-known toxicity is called cytokine release syndrome (CRS) which is a systemic inflammatory response characterized by fever, hypotension and hypoxia (5–7). CRS is triggered by the activation of CAR T cells and their subsequent production of pro-inflammatory cytokines including IFNγ, IL-6 and IL-2. This is thought to result in additional activation of bystander immune and non-immune cells which further produce cytokines, including IL-10, IL-6, and IL-1. The severity of CRS is associated with tumor burden, and ranges from a mild fever to life-threatening organ failure (10, 11). Neurologic toxicity is another serious adverse event which can occur alongside CRS (12).

Irvine, Calif., Oct. 12 2021 — The extract of the plant Corydalis yanhusuo prevents morphine tolerance and dependence while also reversing opiate addiction, according to a recent study led by the University of California, Irvine. The findings were published in the October issue of the journal Pharmaceuticals.

(Link to study: https://pharmsci.uci.edu/uci-led-study-finds-medicinal-plant…-epidemic/)

Over the past two decades, dramatic increases in opioid overdose mortality have occurred in the United States and other nations. During the COVID-19 pandemic, the opioid epidemic has only worsened. The documented effects of YHS, the extract of the plant Corydalis yanhusuo, could have an immediate, positive impact to curb the opioid epidemic.

In the United States, animal health authorities are now on high alert. The US Department of Agriculture has pledged an emergency appropriation of $500 million to ramp up surveillance and keep the disease from crossing borders. African swine fever is so feared internationally that, if it were found in the US, pork exports—worth more than $7 billion a year—would immediately shut down.

“Long-distance transboundary spread of highly contagious and pathogenic diseases is a worse-case scenario,” Michael Ward, an epidemiologist and chair of veterinary public health at the University of Sydney, told WIRED by email. “In agriculture, it’s the analogue of Covid-19.”

As with the Covid pandemic at its start, there is no vaccine—but also as with Covid, there is the glimmer of hope for one, thanks to basic science that has been laying down findings for years without receiving much attention. Two weeks ago, a multinational team led by scientists at the USDA’s Agricultural Research Service announced that they had achieved a vaccine candidate, based on a weakened version of the virus with a key gene deleted, and demonstrated its effectiveness in a field trial, in pigs, in Vietnam.

Iron dome for Guam.

U.S. Army-owned Iron Dome is heading to the Indo-Pacific theater.

To fully digitize the last mile of business, you need to distribute compute power where it’s needed most — right next to IoT devices that collect data from the real world.

SparkBeyond, a company that helps analysts use AI to generate new answers to business problems without requiring any code, today has released its product SparkBeyond Discovery.

The company aims to automate the job of a data scientist. Typically, a data scientist looking to solve a problem may be able to generate and test 10 or more hypotheses a day. With SparkBeyond’s machine, millions of hypotheses can be generated per minute from the data it leverages from the open web and a client’s internal data, the company says. Additionally, SparkBeyond explains its findings in natural language, so a no-code analyst can easily understand it.

The product is the culmination of work that started in 2013 when the company had the idea to build a machine to access the web and GitHub to find code and other building blocks to formulate new ideas for finding solutions to problems. To use SparkBeyond Discovery, all a client company needs to do is specify its domain and what exactly it wants to optimize.

Every Mars rock has a story to tell.

We all know that Mars is a rocky and dusty planet. But what happens when you get up close to its surface? The results are mighty impressive.

On October 13 William Shatner will boldly go where no 90-year-old has gone before.

Daily exposure to chemicals called phthalates, which are used in the manufacture of plastic food containers and many cosmetics, may lead to roughly 100,000 premature deaths among older Americans each year, a new study shows. The resulting annual economic burden is between $40 billion and $47 billion, a value more than quadruple that of previous estimates.

NYU Langone study shows deaths linked to endocrine-disrupting chemicals called phthalates may cost United States billions in lost productivity. Learn more.