Lifeboat Foundation

If you’ve ever seen a petunia with artfully variegated petals, then you’ve seen transposons at work. The flower’s showy color patterns are due to transposable elements, or DNA sequences that can move locations within a genome. Yet when it comes to transposons’ effects on humans, the results might not be as lovely or desirable.

As researchers learn more about these so-called mobile genetic elements, they’ve found increasing evidence that transposons influence and even promote aging and age-related diseases like cancer as well as neurogenerative and autoimmune disorders, says John Sedivy, a professor of biology and director of the Center on the Biology of Aging at Brown. Sedivy is the corresponding author of a new review article in Nature that discusses the latest thinking and research around transposons.

“Let’s put it this way: These things can be pretty dangerous,” said Sedivy. “If they are uncontrolled, and there are many examples of that, transposons can have profound consequences on most forms of life that we know of.”

The Conboys are looking at human trials soon but not with E5. it will be interesting to see how their trial compares to this E5 dog trial.

In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics.

Continue reading “E5 On Dogs Project: Validating The 54% Reduction In Epigenetic Age | Dr Greg Fahy Episode 8” »

You may not have the full story about what network you’re on—and how well you’re protected.

The saying is that they aren’t making any more land yet here we are.

Quick – define common sense

Despite being both universal and essential to how humans understand the world around them and learn, common sense has defied a single precise definition. G. K. Chesterton, an English philosopher and theologian, famously wrote at the turn of the 20th century that “common sense is a wild thing, savage, and beyond rules.” Modern definitions today agree that, at minimum, it is a natural, rather than formally taught, human ability that allows people to navigate daily life.

Continue reading “An AI expert explains why it’s hard to give computers something you take for granted: Common sense” »

What is causing chronic inflammation?

Summary: A new study adds to the growing body of research linking inflammation to depression. Researchers found the molecule histamine directly inhibits the release of serotonin in the brain by attaching to inhibitory receptors on serotonin neurons in mice.

Source: Imperial College London

Continue reading “Histamine and Inflammation Could Be Key Players in Depression” »

The gut microbiota plays an important role in human health and the prevention of disease. As a result, changes in its regular functioning may play a part in some medical conditions, such as irritable bowel syndromeTrusted Source, obesityTrusted Source, and cardiovascular diseasesTrusted Source.

A recent study investigates the connection between high fat diets, gut bacteria, and an increased risk of developing heart disease.

New evidence shows that patients with Long COVID syndrome continue to have higher measures of blood clotting, which may help explain their persistent symptoms, such as reduced physical fitness and fatigue.

The study, led by researchers from RCSI University of Medicine and Health Sciences, is published in the Journal of Thrombosis and Haemostasis.

Previous work by the same group studied the dangerous clotting observed in patients with severe acute COVID-19. However, far less is known about Long COVID syndrome, where symptoms can last weeks to months after the initial infection has resolved and is estimated to affect millions of people worldwide.

Widespread pain, a subset of chronic pain associated with musculoskeletal disorders, is linked to an increased risk of all types of dementias, including Alzheimer’s disease, and a greater risk of stroke.