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Memories and ideas are living organisms | Michael Levin and Lex Fridman

Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=Qp0rCU49lMs.
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*GUEST BIO:*
Michael Levin is a biologist at Tufts University working on novel ways to understand and control complex pattern formation in biological systems.

*CONTACT LEX:*
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*EPISODE LINKS:*
Michael Levin’s X: https://twitter.com/drmichaellevin.
Michael Levin’s Website: https://drmichaellevin.org.
Michael Levin’s Papers: https://drmichaellevin.org/publications/
- Biological Robots: https://arxiv.org/abs/2207.00880
- Classical Sorting Algorithms: https://arxiv.org/abs/2401.05375
- Aging as a Morphostasis Defect: https://pubmed.ncbi.nlm.nih.gov/38636560/
- TAME: https://arxiv.org/abs/2201.10346
- Synthetic Living Machines: https://www.science.org/doi/10.1126/scirobotics.abf1571

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*PODCAST LINKS:*

Next gen cancer drug shows surprising anti aging power

The study unexpectedly identified a significant role for a group of enzymes known as agmatinases, which convert the metabolite agmatine into polyamines. These enzymes appear to participate in a previously unrecognized “metabolic feedback loop” that helps maintain balanced TOR activity. When agmatinase activity was disrupted, yeast cells grew more quickly but showed signs of premature aging, revealing a trade-off between rapid growth and long-term cell survival.

The team also found that adding agmatine or putrescine (a related compound) supported longevity in yeast and improved growth under specific conditions.

“By showing that agmatinases are essential for healthy aging, we’ve uncovered a new layer of metabolic control over TOR — one that may be conserved in humans,” said Dr. Rallis. “Because agmatine is produced by diet and gut microbes, this work may help explain how nutrition and the microbiome influence aging.”

Cannabis Survey Shows Rising CBD Use in Pets

“The long-term use of CBD is associated with less intense aggressive behaviors in dogs.”


Can cannabidiol (CBD) help dogs in the same way it helps humans? This is what a recent study published in Frontiers in Veterinary Science hopes to address as a team of scientists investigated the benefits of incorporating CBD products into dog products. This study has the potential to help scientists, legislators, and the public better understand the health benefits of CBD for both humans and animals.

For the study, the researchers analyzed data obtained from the Dog Aging Project (DAP), which is an organization designed to gain insight into dog aging, lifestyle, diet, and environmental factors. Surveys were conducted from 47,444 dog owners between December 2019 and December 2023, with the first surveys being s baseline regarding a dog’s overall health status, while the second survey was used to ascertain the amount of CBD or hemp the owners fed their dogs while also assessing changes in behavior and/or health.

In the end, the researchers found that healthy dogs were less likely to use CBD, whereas dogs with limiting health conditions like dementia, epilepsy, or cancer were more likely to use CBD. Additionally, CBD-use dogs were found to exhibit less aggressive behavior compared to non-use dogs. Finally, the team found that states where CBD was legal had higher rates of dogs using CBD.

Non-invasive ultrasonic neuromodulation of the human nucleus accumbens impacts reward sensitivity

This study shows that non-invasive ultrasound to the human nucleus accumbens can modulate deep brain activity and enhance reward-guided learning, offering a potential alternative to invasive neuromodulation therapies.

Michelson–Morley experiment

In 1885, Michelson began a collaboration with Edward Morley, spending considerable time and money to confirm with higher accuracy Fizeau’s 1851 experiment on Fresnel’s drag coefficient, [ 5 ] to improve on Michelson’s 1881 experiment, [ 1 ] and to establish the wavelength of light as a standard of length. [ 6 ] [ 7 ] John Brashear made the high-quality optics for the Interferometer in his Allegheny-Observatory-affiliated shop. At this time Michelson was professor of physics at the Case School of Applied Science, and Morley was professor of chemistry at Western Reserve University (WRU), which shared a campus with the Case School on the eastern edge of Cleveland. Michelson suffered a mental health crisis in September 1885, from which he recovered by October 1885. Morley ascribed this breakdown to the intense work of Michelson during the preparation of the experiments. In 1886, Michelson and Morley successfully confirmed Fresnel’s drag coefficient—this result was also considered as a confirmation of the stationary aether concept. [ A 2 ]

This result strengthened their hope of finding the aether wind. Michelson and Morley created an improved version of the Michelson experiment with more than enough accuracy to detect this hypothetical effect. The experiment was performed in several periods of concentrated observations between April and July 1887, in the basement of Adelbert Dormitory of WRU (later renamed Pierce Hall, demolished in 1962). [ A 11 ] [ A 12 ]

As shown in the diagram to the right, the light was repeatedly reflected back and forth along the arms of the interferometer, increasing the path length to 11 m (36 ft). At this length, the drift would be about 0.4 fringes. To make that easily detectable, the apparatus was assembled in a closed room in the basement of the heavy stone dormitory, eliminating most thermal and vibrational effects. Vibrations were further reduced by building the apparatus on top of a large block of sandstone (Fig. 1), about a foot thick and five feet (1.5 m) square, which was then floated in a circular trough of mercury. They estimated that effects of about 0.01 fringe would be detectable.

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