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Polygenic Contributions to Lithium Augmentation Outcomes in Unipolar Depression

Higher polygenic risk scores for bipolar disorder were associated with favorable treatment outcomes after lithium augmentation in antidepressant non-responders with unipolar depression.


Question Are polygenic risk scores (PRS) for major psychiatric disorders associated with favorable treatment outcomes after lithium augmentation (LA) in major depression?

Findings In this cohort study with 193 patients with major depressive disorder (MDD) who did not respond to antidepressants, the PRS for bipolar disorder (BIP) was significantly associated with response and remission after at least 4 weeks of LA. Additionally, we found an association between the MDD-PRS and LA response.

Meaning Individuals with a higher polygenic burden for BIP and lower polygenic burden for MDD are more likely to experience favorable treatment outcomes following LA, offering new opportunities for personalized medicine approaches.

Cell Death Leaves a Footprint That Can Help Viruses Spread

New research finds that dying cells leave a “footprint of death” that guides immune responses — but viruses like influenza can exploit this signaling. The discovery, published in Nature Communications, offers new insight into cell death, viral transmission, and potential drug targets.


New insights into the aftermath of cell death might ultimately inform drug development.

Dr. Carina Kern — CEO, LinkGevity — Necrosis Inhibitors To Pause The Diseases Of Aging

Necrosis Inhibitors To Pause The Diseases Of Aging — Dr. Carina Kern Ph.D. — CEO, LinkGevity


Dr. Carina Kern, Ph.D. is the CEO of LinkGevity (https://www.linkgevity.com/), an AI-powered biotech company driving innovation in drug discovery for aging and resilience loss.

Dr. Kern has developed a new Blueprint Theory of Aging, which takes an integrative approach to understanding aging, combining evolutionary theory, genetics, molecular mechanisms and medicine, and is used to structure LinkGevity’s AI.

Dr. Kern’s labs are based at the Babraham Research Campus, affiliated with the University of Cambridge and her research has led to the development of a first-in-class necrosis inhibitor targeting cellular degeneration (Anti-Necrotic™). This novel therapeutic is ready to begin Phase II clinical trials later this year, as a potential breakthrough treatment for aging, with UK Government, Francis Crick Institute KQ labs, and European Union (Horizon) support.

The Anti-Necrotic™ has also been selected as one of only 12 global innovations for NASA’s Space-Health program, recognizing its potential to mitigate accelerated aging in astronauts on long-duration space missions.

Vegetarian diet and healthy aging among Chinese older adults: a prospective study

From the article:

Following a vegetarian diet can be a boon for your health, even possibly cutting your risk of certain chronic illnesses, according to the Mayo Clinic. Yet a recent study, conducted by nutrition experts and published in the Nature journal npj Aging, suggests that not everyone will experience the same benefits when they cut out meat entirely. Adults over the age of 60 may have different nutritional needs, meaning a more diverse diet could instead help them live longer… Utilizing data from the Chinese Longitudinal Healthy Longevity Survey, the study reviewed information from nearly 2,900 Chinese older adults who were considered to be healthy. Participants’ diets were categorized four ways:

- vegan (avoiding any animal products, including eggs, seafood, or dairy) — ovo-vegetarian (vegetarian plus the inclusion of eggs) — pesco-vegetarian (vegetarian plus the inclusion of fish and seafood) — omnivorous (eating both plant-and animal-based products)

After an average follow-up period of six years, “Individuals who maintained omnivorous diets from age 60 years had higher odds of achieving healthy aging” versus those who “consistently” followed vegetarian eating patterns. When the team further analyzed the health data of those who survived to age 80, omnivorous eaters were more likely than vegetarians to avoid major chronic disease, physical function impairment, and cognitive impairment.

“Given age-related physiological changes in digestive and metabolic systems” in aging adults, the study specifically flagged the potential for muscle loss and bone fracture for those adhering to vegetarian diets. Another interesting discovery: older adults following a vegan diet were “most strongly associated with adverse effects on healthy aging,” which the text attributes to an increased risk of protein deficiency.”


npj Aging — Vegetarian diet and healthy aging among Chinese older adults: a prospective study. npj Aging 11, 25 (2025). https://doi.org/10.1038/s41514-025-00213-4

A new artificial muscle could let humanoid robots lift 4,400 times their weight

A new material bends that rule.

Researchers in South Korea say they have built a soft, magnetic artificial muscle that hits hard numbers without turning into a stiff piston. The material flexes, contracts and relaxes like flesh, yet ramps up stiffness on demand when asked to do real work. That mix has long sat out of reach for humanoid robots that need both agility and strength.

Most humanoids move with a cocktail of motors, gears and pneumatic lines. These systems deliver power, but they also add bulk and make contact risky. Soft actuators change the equation. They integrate into limbs, cushion impacts and tolerate misalignment. They also weigh far less than hydraulic stacks and slot neatly inside compact forms like hands, faces and torsos.

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