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Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers — ATR inhibitor elimusertib and PARP inhibitor AZD5305 — are safe and clinically beneficial in treating patients with advanced solid tumors. Principal investigator Timothy Yap, M.B.B.S., Ph.D., associate professor of Investigational Cancer Therapeutics, today presented new data from the trials at the American Association for Cancer Research (AACR) Annual Meeting 2022.

“DDR orchestrates a complex network of mechanisms that detects and repairs damage to DNA, such as double strand breaks and replication stress,” Yap explained. “However, when DDR defects occur, it promotes uncontrolled cancer cell growth and enables cells to evade apoptosis. The studies suggest that PARP1-selective and ATR inhibitors, which block two key mediators of the DDR signaling pathway, are a promising class of new drugs that offer significant therapeutic potential for patients with cancers harboring synthetic lethal genomic alterations in DDR pathways.”

Expansion trial of ATR inhibitor shows encouraging clinical activity against DDR defects (Abstract CT006)

For the first time ever, doctors have successfully transplanted a kidney from a pig to a human — and, they say, the organ functioned normally.

The procedure occurred between a genetically-altered pig and a brain dead human patient at NYU Langone Health, according to The New York Times. The pig was genetically engineered to grow a kidney that would be accepted by a human body. The organ was then attached to the patient’s blood vessels in the upper leg, outside of the abdomen, where the researchers observed it functioning normally.

“It was better than I think we even expected,” Dr. Robert Montgomery, director of the NYU Langone Transplant Institute, told the NYT. Montgomery helped perform the procedure in September and told the paper that it “looked like any transplant I’ve ever done from a living donor. A lot of kidneys from deceased people don’t work right away, and take days or weeks to start. This worked immediately.”

The most distant exoplanet discovered by the Kepler Space Telescope (17,000 ly), the most distant individual star (12.9 billion ly), and the most distant galaxy ever seen (13.5 billion ly) have all been reported.

Quantum computers, machines that leverage quantum states to perform computations and store data, could soon revolutionize the computing industry, achieving significantly greater speeds and performance than existing computers. While countless companies worldwide, including Google and IBM as well as smaller start-ups, have started working on quantum technologies, the exact architecture that will lead to their mass production remains unclear.

Researchers at Leibniz University Hannover have recently conducted a theoretical study investigating the possibility of realizing flying-qubit gates for quantum computers that are insensitive to the wave shapes of photons, and also fully preserve these shapes during processing. Their paper, published in Physical Review Letters, could serve as the basis for the development of new gates that can process entangled photonic wave packets more effectively than unentangled ones.

“There are several candidate architectures for the development of quantum technology, including superconductors, ion traps, solid state, optical, and so on,” Ihar Babushkin, one of the researchers who carried out the study, told Phys.org. “Regardless of what architecture we consider, photons, the quanta of light, will play an important role, since in almost all architectures the mediators between quantum information bits (qubits) are photons.”

Closes July 31st at Midnight

The Texas Cyber Summit is a three day multi-track novice to ninja technical cybersecurity event held annually with an expectation of over 1,200 participants in-person. Note that the in-person will take place in September 22nd – 24th, and the Virtual Conference will take place in November 5th. Featuring five dedicated learning tracks for the aspiring Cybersecurity novice to the expert operator. Deeply technical, research and management briefings that address the entire cyber threat landscape. The Texas Cyber Summit is held in Austin, Tx and is a IRS 501C3 Non-Profit Organization.

Austin is home to major fortune 500 companies, Cyber Futures Command, Defense Logistics Agency, and Air force logistics. We host Specialized tracks include teaching, training, responsibilities, and ethics in specialized fields such as digital forensics, Scada, Supply Chain, Red Team Tools, Tactics and Procedures, Blue Team and the Art of Defense, and much more.

The system developed in Milano is robust and it also has the potential to process information encoded in different coupled systems, including far and enormous galaxies. Thanks to these new results, it is now possible to simulate in the lab complex coupled systems, with order altered by stable defects, difficult to be reproduced otherwise since involving ginormous scale, like galaxies, or part of extreme hydrodynamic systems.

Water whirlpools, smoke rings, violent tornados and spiral galaxies are all examples of twists in fluids, although very different each other. Analogous twists, but in the realm of light, have been created by the research group coordinated by Antonio Ambrosio at the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology), in Milano (Italy). The results, published in the journal Nature Photonics, show the realization of 100 light vortices, coupled to form an ordered structure, a light crystal.

Mutual interaction of light and nanostructured materials is the focus of the research of Antonio Ambrosio, Principal Investigator of the research line Vectorial Nano-imaging at IIT in Milano and grantee of the ERC Consolidator project “METAmorphoses.”

Continue reading “Optical vortex crystals for photonic simulations of complex systems” »

More than 5,000 new virus species have been identified in the world’s oceans, according to a new study.

The study researchers analyzed tens of thousands of water samples from around the globe, hunting for RNA viruses, or viruses that use RNA as their genetic material. The novel coronavirus, for instance, is a type of RNA virus. These viruses are understudied compared with DNA viruses, which use DNA as their genetic material, the authors said.

Miniaturization lies at the heart of countless technological advances. It is undeniable that as devices and their building blocks get smaller, we manage to unlock new functionalities and come up with unprecedented applications. However, with more and more scientists delving into materials with structures on the atomic scale, the gaps in our current understanding of nanomaterial physics are becoming more prominent.

For instance, the nanomaterial’s surface represents one such knowledge gap. This is because the influence of surface quantum effects becomes much more apparent when the surface-to-volume ratio of a material is high. In nanoelectromechanical systems (NEMS), a current hot topic in research, the physical properties of the nanomaterials greatly differ from their bulk counterparts when their size is reduced to a few atoms. A solid understanding of the mechanical properties of nanowires and nanocontacts—integral components of NEMS—is essential for advancing this technology. But, measuring them has proven a challenging task.

Against this backdrop, a research team from Japan recently achieved an unprecedented feat when they managed to precisely measure the elastic modulus of gold nanocontacts stretched down to a few atoms. The study, published in Physical Review Letters, was led by Prof. Yoshifumi Oshima of Japan Advanced Institute of Science and Technology (JAIST). The rest of the team included post-doctoral research fellow Jiaqi Zhang and Professor Masahiko Tomitori from JAIST, and Professor Toyoko Arai of Kanazawa University.

On April 1st this year, a team of scientists led by NASA’s Jet Propulsion Laboratory posted a proposed new message to be sent to prospective intelligent extraterrestrials. The coincidence of April Fool’s Day in this case should be ignored. This actually is very real. The rationale for the message can be found in an article entitled, “A Beacon in the Galaxy: Updated Arecibo Message for Potential FAST and SETI Projects,” which has been submitted to the journal Galaxy and is currently posted on a pre-print server for review.

The article title includes the terms FAST and SETI. If you are not familiar with FAST, the acronym stands for the Five-Hundred-meter Aperture Spherical Telescope being built in China (see picture above) that will be the largest parabolic radio telescope in the world and capable of intercepting the faintest radio signals from across the Universe. SETI, the Search for Extraterrestrial Intelligence, is far better known and was featured prominently in the science fiction movie, Contact, based on a Carl Sagan novel.

What kind of message is being sent? And how will intelligent aliens be able to decipher it? Since the first radios and television signals were broadcast, humanity has been streaming information into outer space with no thought of how the information would be perceived by an intelligent technically advanced civilization on the receiving end. And even before radios, sending a message to intelligent aliens was proposed. In the early 1800s an Austrian astronomer wanted to carve out a geometric pattern of trenches in the Sahara Desert, fill them with kerosene and then light it all up tobe a beacon for any aliens living nearby.