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Blog – Page 4904

In order to cover the different areas and to manage the large volume of research that has been conducted on the serotonin system, we conducted an ‘umbrella’ review. Umbrella reviews survey existing systematic reviews and meta-analyses relevant to a research question and represent one of the highest levels of evidence synthesis available [23]. Although they are traditionally restricted to systematic reviews and meta-analyses, we aimed to identify the best evidence available. Therefore, we also included some large studies that combined data from individual studies but did not employ conventional systematic review methods, and one large genetic study. The latter used nationwide databases to capture more individuals than entire meta-analyses, so is likely to provide even more reliable evidence than syntheses of individual studies.

We first conducted a scoping review to identify areas of research consistently held to provide support for the serotonin hypothesis of depression. Six areas were identified, addressing the following questions: Serotonin and the serotonin metabolite 5-HIAA–whether there are lower levels of serotonin and 5-HIAA in body fluids in depression; Receptors — whether serotonin receptor levels are altered in people with depression; The serotonin transporter (SERT) — whether there are higher levels of the serotonin transporter in people with depression (which would lower synaptic levels of serotonin); Depletion studies — whether tryptophan depletion (which lowers available serotonin) can induce depression; SERT gene – whether there are higher levels of the serotonin transporter gene in people with depression; Whether there is an interaction between the SERT gene and stress in depression.

We searched for systematic reviews, meta-analyses, and large database studies in these six areas in PubMed, EMBASE and PsycINFO using the Healthcare Databases Advanced Search tool provided by Health Education England and NICE (National Institute for Health and Care Excellence). Searches were conducted until December 2020.

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According to recent research, pig farming’s extensive use of antibiotics has likely contributed to the emergence of a highly antibiotic-resistant strain of the superbug MRSA, or methicillin-resistant Staphylococcus aureus, in livestock during the last 50 years.

Over the last fifty years, the strain, known as CC398, has overtaken other MRSA strains in animals across Europe. It is also a rising source of MRSA infections in humans.

According to the study, CC398 has remained resistant to antibiotics in pigs and other animals for many years. Furthermore, it can quickly adapt to human hosts while still preserving its antibiotic resistance.

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However, the research which was published in PLoS Medicine found that noise levels in the house had no effect on the results of working memory and attention tests.

Road traffic noise is a common issue in cities, but its effects on children’s health are still not fully known. According to recent research done at 38 schools in Barcelona, road noise has a negative impact on how well working memory and attention are developed in young children. The results of this investigation, which was conducted under the direction of the Barcelona Institute for Global Health (ISGlobal), a facility supported by the “la Caixa” Foundation, were released in the journal PLoS Medicine.

2,680 kids between the ages of 7 and 10 participated in the study, which was part of the BREATHE initiative and directed by researchers Maria Foraster and Jordi Sunyer. The researchers focused on attention and working memory, two skills that grow quickly throughout preadolescence and are crucial for learning and academic success, in order to gauge the potential effects of traffic noise on cognitive development.

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The received view in physics is that the direction of time is provided by the second law of thermodynamics, according to which the passage of time is measured by ever-increasing disorder in the universe. This view, Julian Barbour argues, is wrong. If we reject Newton’s faulty assumptions about the existence of absolute space and time, Newtonian dynamics can be shown to provide a very different arrow of time. Its direction, according to this theory, is given by the increase in the complexity and order of a system of particles, exactly the opposite of what the received view about time suggests.

Two of the most established beliefs of contemporary cosmology are that the universe is expanding and that the direction of the arrow of time in the universe is defined by ever-increasing disorder (entropy), as described by the second law of thermodynamics. But both of these beliefs rest on shaky ground. In saying that the universe is expanding, physicists implicitly assume its size is measured by a rod that exists outside the universe, providing an absolute scale. It’s the last vestige of Newton’s absolute space and should have no place in modern cosmology. And in claiming that entropy is what gives time its arrow, physicists uncritically apply the laws of thermodynamics, originally discovered through the study of steam engines, to the universe as a whole. That too needs to be questioned.

Time min

Einstein and why the block universe is a mistake Read more In the absence of an absolute space and external measuring rods, size is always relative — relative to a measure of distance internal to the system. Starting from the simplest case, a triangle, what we find is that the internal measure of size produces a ratio which also happens to be related to a mathematical measure of complexity that intriguingly plays the central role in Newtonian universal gravitation. Applying these findings to the universe as a whole, we find that Newton’s theory of gravity, contrary to what physicists believe, contains within it an intrinsic arrow of time. This provides a strong hint that the direction of time is not defined by an increase in entropy, but by an increase in structure and complexity.

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Got a protein? This AI will tell you what it looks like.

AlphaFold was recognized by the journal Science as 2021’s Breakthrough of the Year, beating out candidates like Covid-19 antiviral pills and the application of CRISPR gene editing in the human body. One expert even wondered if AlphaFold would become the first AI to win a Nobel Prize.

The breakthroughs have kept coming.

Last week, DeepMind announced that researchers from around the world have used AlphaFold to predict the structures of some 200 million proteins from 1 million species, covering just about every protein known to human beings. All of that data is being made freely available on a database set up by DeepMind and its partner, the European Molecular Biology Laboratory’s European Bioinformatics Institute.

Continue reading “Finally, an answer to the question: AI — what is it good for?” | >

Japanese studio Nendo has created an archive to house its products and furniture from precast concrete box culverts in central Japan.

Named Culvert Guesthouse, the archive and residence was constructed from four tunnel-like forms that were stacked on top of each other.

Designed by the studio as its own archive, the distinctive-shaped building is located in dense woodland on the edge of the town of Miyota in Nagano Prefecture.

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In February 2020, four distinguished astrophysicists — Jonathan Carroll-Nellenback, Adam Frank, Jason Wright, Caleb Scharf — suggested that Earth may have remained unvisited by space-faring civilizations all the while existing in a galaxy of interstellar civilizations seeded by moving stars that spread alien life, offering a solution to the perplexing Fermi paradox. They concluded that a planet-hopping civilization could populate the Milky Way in as little as 650,000 years.

“It’s possible that the Milky Way is partially settled, or intermittently so; maybe explorers visited us in the past, but we don’t remember, and they died out,” says Jonathan Carroll-Nellenback, an astronomer at the University of Rochester and his collaborators in a 2019 study that suggests it wouldn’t take as long as thought for a space-faring civilization to planet-hop across the galaxy, because the orbits of stars can help distribute life, offering a new solution to the Fermi paradox. “The solar system may well be amid other settled systems; it’s just been unvisited for millions of years.”

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Scientists at Nagoya University in Japan claim to have discovered dark matter that dates back 12 billion years ago, which would make it the earliest observation of the hypothetical substance to date.

Their findings — as detailed in a new paper published in the journal Physical Review Letters — could potentially offer some tantalizing answers about the nature of the universe.

Until now, observations of dark matter only went as far back as ten billion years. Any further than that, and the light was too faint to observe.

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