Lifeboat Foundation

Remote inflammation in rheumatoid arthritis spreads by neuron crosstalk, and the molecule adenosine triphosphate (ATP) plays a key role in this.

Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that mainly causes painful joints. It’s estimated to affect over 450,000 Australians.

Continue reading “Key to spreading inflammation in rheumatoid arthritis found” »

Using a new gene therapy technique, researchers at the University of California San Diego reduced neuropathic pain resulting from spinal cord or other nerve injuries in mice — and with no detectable side effects.

The research is highly intriguing because it could lead to new treatment options for the untold numbers of patients who experience chronic pain, numbness or weak muscles as a result of spinal cord injuries.

Treating nerve damage or dysfunction, otherwise known as neuropathy, with drugs can often lead to side effects. These drugs also have to be administered continuously, and opioids — which are particularly effective painkillers — can often lead to addiction issues.

Background An attempt was made to reprogram peripheral blood cells into human induced pluripotent stem cell (hiPSCs) as a new cell source for cartilage repair. Methods We generated chondrogenic lineage from human peripheral blood via hiPSCs using an integration-free method. Peripheral blood cells were either obtained from a human blood bank or freshly collected from volunteers. After transforming peripheral blood cells into iPSCs, the newly derived iPSCs were further characterized through karyotype analysis, pluripotency gene expression and cell differentiation ability. iPSCs were differentiated through multiple steps, including embryoid body formation, hiPSC-mesenchymal stem cell (MSC)-like cell expansion, and chondrogenic induction for 21 days. Chondrocyte phenotype was then assessed by morphological, histological and biochemical analysis, as well as the chondrogenic expression.

An attempt was made to reprogram peripheral blood cells into human induced pluripotent stem cell (hiPSCs) as a new cell source for cartilage repair.

We generated chondrogenic lineage from human peripheral blood via hiPSCs using an integration-free method. Peripheral blood cells were either obtained from a human blood bank or freshly collected from volunteers. After transforming peripheral blood cells into iPSCs, the newly derived iPSCs were further characterized through karyotype analysis, pluripotency gene expression and cell differentiation ability. iPSCs were differentiated through multiple steps, including embryoid body formation, hiPSC-mesenchymal stem cell (MSC)-like cell expansion, and chondrogenic induction for 21 days. Chondrocyte phenotype was then assessed by morphological, histological and biochemical analysis, as well as the chondrogenic expression.

HiPSCs derived from peripheral blood cells were successfully generated, and were characterized by fluorescent immunostaining of pluripotent markers and teratoma formation in vivo. Flow cytometric analysis showed that MSC markers CD73 and CD105 were present in monolayer cultured hiPSC–MSC-like cells. Both alcian blue and toluidine blue staining of hiPSC–MSC-chondrogenic pellets showed as positive. Immunohistochemistry of collagen II and X staining of the pellets were also positive. The sulfated glycosaminoglycan content was significantly increased, and the expression levels of the chondrogenic markers COL2, COL10, COL9 and AGGRECAN were significantly higher in chondrogenic pellets than in undifferentiated cells. These results indicated that peripheral blood cells could be a potential source for differentiation into chondrogenic lineage in vitro via generation of mesenchymal progenitor cells.

Over 3.6 million MySQL servers are publicly exposed on the Internet and responding to queries, making them an attractive target to hackers and extortionists.

Of these accessible MySQL servers, 2.3 million are connected over IPv4, with 1.3 million devices over IPv6.

While it is common for web services and applications to connect to remote databases, these instances should be locked down so only authorized devices can connect to them.

WhatsApp is one of the most popular messaging platforms in the world with over 2 billion users. Thanks to its massive user base, it has also become a breeding ground for scammers and hackers involved in malicious activities. Now, according to a recent report, a WhatsApp scam that enables an attacker to take control of a user’s WhatsApp account is currently in operation. Check out the details below right now!

According to a recent report by Gizchina, citing cybersecurity firm CloudSEK, a new scam currently targeting random WhatsApp users lets an attacker completely take control of their WhatsApp account with only a phone call. Once an attacker takes hold of a WhatsApp account, they can demand money from the user’s WhatsApp contacts.

The new scam was recently discovered by Rahul Sasi, who is the founder and CEO of CloudSEK. According to him, the primary objective of the hacker is to randomly call an unsuspecting WhatsApp user and try to convince them to call a specific number. If a user, unfortunately, dials the number as instructed by the attacker, they will be logged out of their WhatsApp account and the hacker will be able to take control of it.

DARPA Funded Scientists Accidently Discover World’s First ‘WARP BUBBLE’ And Opens The Door To Travel Faster Than Light Casimir cavity.

Two-dimensional (2D) surface profiling systems are the standard for quality assurance in manufacturing, but some applications demand 3D measurement systems.

Two-dimensional surface profiling systems are excellent for measuring surface finish under certain conditions, but three-dimensional measurement systems offer more robust data. Photo Credit: George Schuetz.

“In the beginning,” as some might say, an experienced machinist would use a scratch pad and an educated fingernail to determine the surface quality of a part. Then, in the 1940s, the first series of electronic surface finish gages were developed. Today, machinists and quality labs have surface finish standards and parameters and a variety of gages to measure surfaces.

There are two basic varieties of surface finish gage: skid-type, or averaging systems and skidless, or profiling systems. Skidded gages have a hinged probe assembly, with the probe riding next to a relatively broad skid that also contacts the workpiece. The skid tends to filter out waviness, so the probe measures only short-wavelength variations. A skidded gage usually has a dial or LCD readout to display the measurement as a single numerical value.

In theory, the fabric of space could have been curved in any way imaginable. So why is the Universe flat when we measure it?