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Mathematics for Computer Science

This course covers elementary discrete mathematics for computer science and engineering. It emphasizes mathematical definitions and proofs as well as applicable methods. Topics include formal logic notation, proof methods; induction, well-ordering; sets, relations; elementary graph theory; integer congruences; asymptotic notation and growth of functions; permutations and combinations, counting principles; discrete probability. Further selected topics may also be covered, such as recursive definition and structural induction; state machines and invariants; recurrences; generating functions.

Planetary microbiome structure and generalist-driven gene flow across disparate habitats

Now online! A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological boundaries to mediate gene flow across disparate habitats, including the dissemination of antimicrobial resistance.

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins

The full list of differentially expressed proteins was compared to the list of aging biomarkers in blood determined by the TAME working group (Justice et al. 2018), see full list of APs in Table S2d. Of the seven aging biomarkers selected by TAME as gold standard, five proteins (CST3, GDF15, IL6, NPPB, TNF) were available and significantly differentially expressed when comparing healthy controls with centenarians or with geriatric patients; two proteins (CRP, IGF1) were unavailable from the Olink panels (Cardiometabolic I and Inflammation I).

On the expanded list of blood-based biomarkers (74 total) selected by TAME, when comparing healthy controls with centenarians, 47 biomarkers were not available in both panels (63.5%). Of the available markers, 23 were significantly differentially expressed in centenarians (85.2%) and 4 were not significantly differentially expressed in centenarians (14.8%). When comparing healthy controls with geriatric patients, 47 biomarkers were not available in both panels (63.5%); 25 were significantly differentially expressed in the geriatric group (92.6%), and only 2 were not significantly differentially expressed in hospitalized geriatric patients (7.4%). Only 2 proteins (SERPINE1, SOD1) among the 25 proteins available in the SWISS100 dataset demonstrated different results in both comparisons (Healthy2Cent and Healthy2Geriatric). Thus, both the short and expanded list of blood-based biomarkers proposed by TAME as APs are highly reproducible in the SWISS100 study based on proximity extension assay. Table S2d contains the complete list of DEPs in blood with age that overlap between both studies.

We Just Found a Mind-blowing New World of Electrostatic Biology

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Hello and welcome! My name is Anton and in this video, we will talk about a strange electrostatic world of tiny organisms.
Links:
https://www.pnas.org/doi/epdf/10.1073/pnas.2503555122
https://www.cell.com/action/showPdf?pii=S0960-9822%2823%2900674-7
http://cell.com/current-biology/fulltext/S0960-9822(23)00772-8
Other videos:


#biology #science #electrostatics.

0:00 Static phenomena and electrostatic ecology.
1:50 Pollen and bees.
3:00 Flying spiders and ballooning.
4:10 Ticks.
4:40 Electrosensation.
5:40 Worms and jumping.
7:50 Worm parasites.
9:50 Practical applications and aeroplankton.

Enjoy and please subscribe.

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Continue reading “We Just Found a Mind-blowing New World of Electrostatic Biology” | >

‘Remnant’ Cholesterol Cut by More Than 60 Percent in New Drug Trial

Hopes are high for a powerful new compound aimed at lowering blood fat levels responsible for potentially fatal heart disease. In a recent trial, the oral drug, TLC-2716, lowered blood triglycerides by almost 40 percent and remnant cholesterol by more than 60 percent.

The drug was tested in a clinical trial involving 100 healthy adults to assess its effects on a metabolic switch that is active in the liver and gut, and involved in making and handling fats. The trial was the first of its kind on humans, and more testing is required.

Researchers initially isolated the switch, called Liver X Receptor ⍺ (LXR⍺), through analysis of large human genetics databases. Then they linked it to blood-fat-related metabolic disorders using Mendelian randomization, a powerful technique for linking gene expression and outcomes.

Why NASA Built SLS — And Why It Couldn’t Have Happened Any Other Way

Why NASA Built SLS — And Why It Couldn’t Have Happened Any Other Way.

(https://youtu.be/LRwQqZGascs)

The inside scoop you never heard before.

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DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

Unrepaired DNA-protein crosslinks—highly toxic tangles of protein and DNA—cause a process that leads to premature aging and embryonic lethality in mice.

The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease.

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences. Loss of SPRTN activity during replication and mitosis lead to unresolved DNA damage, chromosome segregation errors, micronuclei formation, and cytosolic DNA release that activates the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway. In a Sprtn knock-in mouse model of Ruijs-Aalfs progeria syndrome, chronic cGas-Sting signaling caused embryonic lethality through inflammation and innate immune responses. Surviving mice displayed aging phenotypes beginning in embryogenesis, which persisted into adulthood.

A smashing success: Relativistic Heavy Ion Collider wraps up final collisions

Just after 9 a.m. on Friday, Feb. 6, 2026, final beams of oxygen ions—oxygen atoms stripped of their electrons—circulated through the twin 2.4-mile-circumference rings of the Relativistic Heavy Ion Collider (RHIC) and crashed into one another at nearly the speed of light inside the collider’s two house-sized particle detectors, STAR and sPHENIX. RHIC, a nuclear physics research facility at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory has been smashing atoms since the summer of 2000. The final collisions cap a quarter century of remarkable experiments using 10 different atomic species colliding over a wide range of energies in different configurations.

The RHIC program has produced groundbreaking discoveries about the building blocks of matter and the nature of proton spin and technological advances in accelerators, detectors, and computing that have far surpassed scientists’ expectations when this discovery machine first turned on.

“RHIC has been one of the most successful user facilities operated by the DOE Office of Science, serving thousands of scientists from across the nation and around the globe,” said DOE Under Secretary for Science Darío Gil. “Supporting these one-of-a-kind research facilities pushes the limits of technology and expands our understanding of our world through transformational science—central pillars of DOE’s mission to ensure America’s security and prosperity.”

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