Genetic switches near the FTO locus may enable hibernators’ extreme metabolic resilience and could inspire future treatments for human metabolic and age-related diseases.
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Association of Interictal Respiratory Variability and Severity of Postictal Hypoxemia After Generalized Convulsive Seizures
In an observational cohort study based on the Atherosclerosis Risk in Communities-Neurocognitive Study (ARIC-NCS), the presence of lobar and mixed CMBs was associated with incident dementia. stroke.
BACKGROUND: Cerebral microbleeds (CMBs) are associated with dementia, but the impact of specific microbleed patterns (with distinct pathophysiologies) is unclear. Lobar CMBs commonly result from cerebral amyloid angiopathy (sometimes with cortical superficial siderosis [cSS]), while subcortical microbleeds indicate a hypertensive cause. This study investigates the association of CMB presence, patterns, and frequency with dementia risk. METHODS: Participants from the ARIC-NCS (Atherosclerosis Risk in Communities-Neurocognitive Study), a community-based longitudinal cohort, with a 3T research magnetic resonance imaging at visit 5 (2011–2013) without prior intracerebral hemorrhage or dementia, were included. CMB and cSS presence and location were evaluated using a T2 gradient-recalled echo sequence.
Intracellular bacteria modulate the immune microenvironment of oral squamous cell carcinoma
Wang et al. apply INVADEseq to probe intracellular bacteria in oral squamous cell carcinoma patients treated with neoadjuvant immunotherapy. They show that bacteria modulate immune efficacy, identify specific response predictors, and uncover the impact of bacteria on the communication between predictors and cDC1s.
Plasma p-tau217 Cutoffs, Kidney Function, BMI, and Anemia
Biologically informed plasma pTau217 thresholds improved diagnostic accuracy for amyloid PET positivity in patients with CKD and anemia vs a standard single cutoff, supporting cost-efficient biomarker implementation in AlzheimerDisease screening.
Question For plasma phosphorylated tau 217–based amyloid-β detection, does the strategy of using biological subgroup–specific optimal single cutoffs or a double cutoff better optimize diagnostic accuracy and cost efficiency?
Findings This cohort study found that subgroup-specific optimal cutoffs improved accuracy over the standard single cutoff, especially in chronic kidney disease (CKD) and anemia. Compared with a double cutoff, the optimal cutoff had similar or better accuracy in CKD with lower cost, whereas a double cutoff was slightly better in underweight and anemia but created intermediates; in obesity, a double cutoff remained superior.
Meaning Biologically optimized cutoffs offer a balanced, cost-efficient default, particularly in CKD and anemia, while a double cutoff retains advantages in obesity.
Technical Advance alert 🙌
https://doi.org/10.1172/jci.insight.
In this Research article, Benjamin D. Philpot & team establish a multimodal dual-reporter mouse that accelerates AngelmanSyndrome therapeutic development through scalable cell-based screening, high-resolution whole-brain mapping, non-invasive live imaging, and sorting neurons with unsilenced paternal Ube3a.
2Animal Models Core.
3Department of Genetics, and.
4Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
Now online! The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.
#lifeextension
In 2026 we will have first application of Yamanaka Factors
in Humans, in human eye. This will open a door to further
development in the field of cellular reprograming, aiming
full body rejuvenation in not so far future.
This is the time to take care of your health and your loved one.
Healthier and longer life is already here.
Read more
Religion & Spirituality
Dear Lifeboaters! My book ***Why Space? The Purpose of People*** just hit #1 in Astronomy of the Universe on Amazon! Help us keep it there: grab a copy today — or if you already have one, share this post, buy copies for friends and your team, and PLEASE leave a review if you like it. BTW — the KIndle version is FREE with a subscription!
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