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Rates of heart failure associated with the growing illicit use of the stimulant drug methamphetamine, or meth for short, are rising worldwide and now affect a wide range of socio-economic and racial groups, finds a review of the available evidence, published online in the journal Heart.

Meth heart failure is also more severe than that experienced by those who don’t use the drug, and warrants increased public awareness and availability of treatment for meth addiction to stem the rising tide of those affected, urge the researchers.

Previously published research shows that use of the drug, also popularly known as “crystal meth,” “ice” and “speed,” is associated with serious health problems, including high blood pressure, heart attack, stroke, and even sudden death. But there are no comprehensive systematic reviews of published research on meth use and heart failure, and this prompted a team of U.S. and Canadian researchers to try to bridge this knowledge gap.

Cajal Neuroscience, a biotechnology company integrating human genetics, functional genomics and advanced microscopy to discover novel targets and therapeutics for neurodegeneration, has launched with the completion of a $96 million Series A financing.

The financing was led by The Column Group and Lux Capital, with additional participation from Two Sigma Ventures, Evotec, Bristol Myers Squibb, Alexandria Venture Investments, Dolby Family Ventures and other investors.

Longevity. Technology: Seattle-based Cajal is committed to discovering novel therapeutics for neurodegeneration; by focusing on the mechanistic, spatial and temporal complexity of neurodegeneration, the biotech’s powerful platform is designed to unlock the complexity of disease at unprecedented scale, and integrates expertise in neuroscience, neuroanatomy and computational biology with state-of-the-art technologies for high-throughput functional validation.

Cardiac alterations in structure and function, namely, the left ventricle, have been intensely studied for decades, in association with aging. In recent times, there has been keen interest in describing myocardial changes that accompany skeletal muscle changes in older adults. Initially described as a cardio-sarcopenia syndrome where alterations in myocardial structure were observed particularly among older adults with skeletal muscle sarcopenia, investigations into this syndrome have spurred a fresh level of interest in the cardiac-skeletal muscle axis. The purpose of this perspective is to summarize the background for this “syndrome of concern,” review the body of work generated by various human aging cohorts, and to explore future directions and opportunities for understanding this syndrome.

The traditional view of cardiovascular aging is that of age-related adaptations in the heart characterized by increased left ventricular (LV) mass (LVM) and LV hypertrophy (LVH), which are often secondary to increased systolic blood pressure mainly mediated by arterial stiffening (1, 2). These changes accumulate throughout the lifetime of an individual, increasing the risk of developing cardiovascular disease (CVD), such as heart failure (HF) and coronary artery disease. The incidence of CVD increases with age, rising from ∼78% among adults aged 60–79 years to ∼90% in those aged above 80 years. CVD is the leading cause of disease burden in the world, with global prevalence doubling from 271 million to 523 million between 1990 and 2019. Incident CVD mortality increased from 12.1 million to 18.6 million in the same period , and accounted for 32% of all deaths. With rapidly aging national populations, these numbers are expected to increase.

A simple design overcomes a substantial limitation on the potential applications for coherent perfect absorbers.

ChatGPT wants to answer your queries, even if it doesn’t know the answer.

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Ultrafast science has begun to tackle the measurement of electronic and chemical processes taking place on the few-femtosecond-to-attosecond timescale. This field requires high-power, extremely short-duration laser pulses. Here we review progress towards the generation of such pulses by Raman scattering in a medium whose component molecules oscillate in phase, which modulates the optical polarizability of the medium and generates high-order Raman sidebands on a field propagating through it. This process may occur with high efficiency and thus lead to sufficient bandwidth for supporting few-femtosecond to attosecond pulses. Significant progress has recently been made in the use of this technique to deliver useable ultrashort pulses in the visible to ultraviolet regions of the spectrum.

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Billeh et al. systematically integrate multi-modal data about neuron types, connectivity, and sensory innervations to create biologically realistic models of the mouse primary visual cortex at two levels of resolution, shared freely as a community resource.

Quantum experiment conducted on Google’s Sycamore 2 computer transferred data across two simulated black holes, adding weight to the holographic principle of the universe.

The researchers discovered a mutation in the thrombospondin-1 (THBS1) gene in three ethnically and geographically diverse families with a history of childhood glaucoma using advanced genome-sequencing technology. The researchers then confirmed their findings in a mouse model that had the genetic mutation and developed glaucoma symptoms due to a previously unknown disease mechanism.

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This increase in pressure not only damages the optic nerve but can also affect other structures in a child’s eye like the cornea. Children with childhood glaucoma typically require surgeries as early as the first three to six months of life, followed by several more operations throughout their childhood.