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New therapeutic has the potential to treat inflammatory bowel disease by targeting a molecule that keeps order in the intestines.

Salk Institute scientists have developed a new drug that acts like a master reset switch in the gut. Called FexD, the compound has previously been found to burn fat, lower cholesterol, and ward off colorectal cancer in mice. Now, the team reports that FexD can also prevent and reverse intestinal inflammation in mouse models of inflammatory bowel disease. The study was published on December 12, 2022, in the journal Proceedings of the National Academy of Sciences.

“The Salk-developed drug FexD provides a new way to restore balance to the digestive system and treat inflammatory diseases that are currently very difficult to manage,” says Salk Professor Ronald Evans, senior author of the study. Evans is also director of Salk’s Gene Expression Laboratory and March of Dimes Chair in Molecular and Developmental Biology.

Astronomical winter officially begins this Wednesday and Jack Frost will arrive in full force.

Temperatures will take a polar plunge this week, and even Florida won’t be spared, thanks to a strong high-pressure system sliding south from Canada.

“Very cold Arctic air masses will envelop much of the central and eastern half of the nation during the two week period, including the busy holiday travel season,” the Climate Prediction Center said.

Structures made out of building blocks can shift their shape and autonomously self-organize to a new configuration. The physicists Saeed Osat and Ramin Golestanian from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) revealed this mechanism which may be used to actively manipulate molecular organization. A seed of the novel desired configuration is sufficient to trigger reorganization.

This principle can be applied on to biological building blocks which are constantly recycled to form new structures in living systems.

The concept of remodeling is familiar to most people: those who have ever played with Lego bricks know that many combinations and structures possible from the same components.

Soft robots have phenomenally advanced in recent years. Microscale soft robots designated to navigate difficult paths and perform biological functions in the human body could have profound potential biomedical applications such as surgery, prosthetics, and pain relief.

Currently, the intrinsic functionalization of bio-inspired soft robots is based on elastomeric materials such as silica gel, which requires introducing bulky components and extensive processing steps. They have major limitations in their extent of deformability as compared to their natural biological counterparts.

Continue reading “Researchers pioneer biocompatible all-water ‘Aquabots’” »

It takes chemist Liaisan Khasanova less than a minute to turn an ordinary silica glass tube into a printing nozzle for a very special 3D printer. The chemist inserts the capillary tube—which is just one millimeter thick—into a blue device, closes the flap and presses a button. After a few seconds there is a loud bang and the nozzle is ready for use.

“A laser beam inside the device heats up the tube and pulls it apart. Then we suddenly increase the tensile force so that the glass breaks in the middle and a very sharp tip forms,” explains Khasanova, who is working on her Ph.D. in chemistry in the Electrochemical Nanotechnology Group at the University of Oldenburg, Germany.

Khasanova and her colleagues need the minuscule nozzles to print incredibly tiny three-dimensional metallic structures. This means the nozzles’ openings must be equally tiny—in some cases so small that only a single molecule can squeeze through. “We are trying to take 3D printing to its technological limits,” says Dr. Dmitry Momotenko, who leads the junior research group at the Institute of Chemistry. His goal: “We want to assemble objects atom by atom.”

Lawrence Livermore National Laboratory (LLNL) scientists have created vertically aligned single-walled carbon nanotubes on metal foils that could be a boon for energy storage and the electronics industry.

Vertically aligned carbon nanotubes (VACNTs) have exceptional mechanical, electrical and transport properties in addition to an aligned architecture, which is key for applications such as membrane separation, thermal management, fiber spinning, electronic interconnects and energy storage.

To date, widespread integration of VACNTs into next-generation technologies is thwarted by a lack of compatible, economic, mass-production capabilities. High-quality VACNTs are typically made on substrates such as silicon (Si) or quartz wafers that are rigid, expensive and electrically insulating.

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Continue reading “L. plantarum Increases Muscle Mass And Physical Function (Part II)” »

We sure do love those government subsidies, says industry cheerleader.

Fusion News overblown.

NEW YORK, Dec 13 (Reuters Breakingviews) — A fusion breakthrough unveiled on Tuesday by the U.S. Department of Energy is a scientific tour de force, and a commercial irrelevancy.

It’s a notable feat that researchers produced more energy from fusing atoms together than they used to start the process. The development has been an elusive goal since the 1930s, promising essentially limitless power from cheap hydrogen found in seawater. One gram of hydrogen theoretically contains as much energy as burning about 10 tons of coal.

Continue reading “Nuclear fusion triggers an overreaction” »