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Oct 25, 2022

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

Posted by in categories: biotech/medical, genetics

There now genetic testing of breast cancer for men and women. The mutations in BRCA1 and BRCA2 Genes will cause cancer. I think in the future though error correction in the dna code could lead to the cure using crispr.


The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast Cancer Linkage Consortium. Families were included without regard to the occurrence of ovarian or other cancers. Overall, disease was linked to BRCA1 in an estimated 52% of families, to BRCA2 in 32% of families, and to neither gene in 16% (95% confidence interval [CI] 6%–28%), suggesting other predisposition genes. The majority (81%) of the breast-ovarian cancer families were due to BRCA1, with most others (14%) due to BRCA2. Conversely, the majority of families with male and female breast cancer were due to BRCA2 (76%). The largest proportion (67%) of families due to other genes was found in families with four or five cases of female breast cancer only. These estimates were not substantially affected either by changing the assumed penetrance model for BRCA1 or by including or excluding BRCA1 mutation data. Among those families with disease due to BRCA1 that were tested by one of the standard screening methods, mutations were detected in the coding sequence or splice sites in an estimated 63% (95% CI 51%–77%). The estimated sensitivity was identical for direct sequencing and other techniques. The penetrance of BRCA2 was estimated by maximizing the LOD score in BRCA2-mutation families, over all possible penetrance functions. The estimated cumulative risk of breast cancer reached 28% (95% CI 9%–44%) by age 50 years and 84% (95% CI 43%–95%) by age 70 years. The corresponding ovarian cancer risks were 0.4% (95% CI 0%–1%) by age 50 years and 27% (95% CI 0%–47%) by age 70 years. The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in BRCA2 carriers.

Oct 25, 2022

How scientists want to make you young again

Posted by in category: life extension

Research labs are pursuing technology to “reprogram” aging bodies back to youth.

Oct 25, 2022

Space-cleaning robots could be developed thanks to novel device that was inspired by wilting passion fruits

Posted by in categories: robotics/AI, space

Turns out, dehydrated passion fruits exhibit a type of symmetry not previously known, inspiring self-adapting robots that could one day ‘grasp’ space junk.

A previously unknown type of wrinkling pattern on the surface of dehydrated passion fruits inspired the invention of a device that could be used to clean up space debris and hazardous materials, according to South Morning China Post (SMCP)

The real-life application comes after Fan Xu, Xi-Qiao Feng and colleagues at Fudan University in Shanghai reported an unknown type of chiral wrinkling pattern on the surface of dehydrated passion fruits in their study published in the journal Nature Computational Science the same day. previously unknown type of wrinkling pattern on the surface of dehydrated passion fruits inspired the invention of a device that could be used to clean up space debris and hazardous materials, according to South Morning China Post (SMCP).

Oct 25, 2022

This 3D-printed wearable mosquito repellent could finally end re-applying sprays

Posted by in category: wearables

The study is in the early phase but promising.

We use body sprays to get rid of mosquitos most of the time. We can even use herbs such as sage and rosemary to keep them out of our homes. Martin Luther University Halle-Wittenberg scientists have created a novel method of delivering insect repellent (MLU). The results were published in the.

The researchers used “IR3535,” an insect repellent created by MERCK, to create their prototypes.

Continue reading “This 3D-printed wearable mosquito repellent could finally end re-applying sprays” »

Oct 25, 2022

Auroras are responsible for punching holes in the ozone layer

Posted by in categories: particle physics, space

A type of aurora briefly tore a 400 km wide hole in Earth’s ozone layer.

An international team of researchers showed that a certain type of aurora called the “Isolated proton aurora” depletes our atmosphere’s ozone layer. They discovered a nearly 250-mile-wide (400 kilometers) hole in the ozone layer right above where an aurora occurred. Before now, the influence of these particles was only vaguely known. The study is published in Scientific reports.

What causes the auroras?

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Oct 25, 2022

Your cat knows the difference between speech directed to them and to a stranger

Posted by in category: futurism

Iva Vagnerova/iStock.

A small-scale study observing 16 cats has revealed that cats actually know when they hear their owner’s voice that the owner’s tone is directed to them. They change their behaviors to show that they understand, according to a press release.

Oct 25, 2022

Researchers looked deep inside the brain to see how memory is stored

Posted by in categories: biotech/medical, health, neuroscience

This is the first study to record such electrical activity from inside the brain.

How do people remember the things they’ve learned? To get to the bottom of the mystery, scientists undertook a study that looked deep inside the brain.

Neuroscientists from Northwestern University and clinicians from the University of Chicago Epilepsy Center examined the electrical activity in the brains of five patients at the center in response to sounds administered by the research team as part of a learning exercise.

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Oct 25, 2022

Video: An engineer produces a torch-like prosthetic for his lost eye

Posted by in categories: biotech/medical, cyborgs

He turned a crisis into an opportunity.

Brian Stanley is a living human cyborg. He has gone viral after sharing a video on social media with an eye flashlight that can light up the whole room. After losing one eye to cancer.

As Brian Stanley suggested in the video, the eye has a battery life of roughly 20 hours, and “it does not get hot.”

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Oct 25, 2022

FDA gives clearance to Philips for its AI powered MRI scans

Posted by in categories: biotech/medical, robotics/AI

The artificial intelligence software speeds up the process of taking scans.

Philips received clearance from the FDA for its artificial intelligence MR platform that is used to detect cancerous tumors in the head and neck.


FDA clearance for AI technology

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Oct 25, 2022

Rats with backpacks will be the savior of earthquake survivors

Posted by in category: transportation

They’re tiny but have a knack for saving human life.

The Belgian non-profit organization APOPO trains rats to help earthquake survivors. Called RescueRATs, these rats are preparing to save those under the earthquake debris with their high-tech backpacks on their backs.

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