Lifeboat Foundation

San Diego-based biotech startup Rejuvenate Bio is making a major claim that’ll likely draw heated scrutiny from the scientific community: that its technology was able to significantly extend the lives of elderly mice.

According to a yet-to-be-peer-reviewed paper, scientists at the company say an injection that reprograms genes in the bodies of senior mice effectively doubled their remaining life span, MIT Technology Review reports.

In tests, the company found that treated mice lived on for another 18 weeks on average. Those who were not treated in a control group only lived for another nine weeks. Overall, they say, the gene hacked mice lived roughly seven percent longer overall.

Scientists from The Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered that a protein, called Menin, contributes to abnormal deactivation of specific genes in cancer cells.

One of the hallmarks of cancer is that the normal regulation of genes is disrupted, and this causes cancer cells to look and behave differently to normal cells. Cancer cells can switch off certain genes, keeping them in a dormant state. By deactivating specific immune genes, some cancers are able to evade detection by the immune system, essentially becoming invisible. This allows the cancer to grow and become more aggressive.

By targeting the Menin protein using drug therapies, the researchers believe they can reactivate these genes, making the cancer cells once again visible and allowing the immune system to seek out and destroy them.

DeepMind brought artificial intelligence mainstream. Now its CEO Demis Hassabis is issuing a warning.

Tesla is the cheapest luxury brand to maintain, and not just among electric vehicle brands, but also those with internal combustion engines (ICE), according to a new study.

The findings come from Clunker Junker which looked at maintenance cost data from the last ten years and cross-referenced vehicle price data.

As in most auto studies, they divided brands and vehicles into popular and luxury. The popular car winner was Toyota. The Japanese automaker took eight of the top ten cheapest cars to maintain.

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Continue reading “Aubrey De Grey: An Antidote to Aging” »

Written by Cláudio Afonso | [email protected] | LinkedIn | Twitter

Hertz reported on Monday its second quarter financial results following a conference call with the company’s management team. During the call, Hertz’s CEO said the company has 20,000 cars in the fleet — from the 100,000 deal — and also that deliveries are ongoing.

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Victoria Krakovna is a Research Scientist at DeepMind working on AGI safety and a co-founder of the Future of Life Institute, a non-profit organization working to mitigate technological risks to humanity and increase the chances of a positive future. In this interview we discuss three of her recent LW posts, namely DeepMind Alignment Team Opinions On AGI Ruin Arguments, Refining The Sharp Left Turn Threat Model and Paradigms of AI Alignment.

Transcript & Audio: https://theinsideview.ai/victoria.

Continue reading “Victoria Krakovna–AGI Ruin, Sharp Left Turn, Paradigms of AI Alignment” »

Biorealistic organic electrochemical neurons enabled by ion-tunable antiambipolarity in mixed ion-electron conducting polymers.

An artificial organic neuron that closely mimics the characteristics of biological nerve cells has been created by researchers at Linköping University (LiU), Sweden. This artificial neuron can stimulate natural nerves, making it a promising technology for various medical treatments in the future.

Work to develop increasingly functional artificial nerve cells continues at the Laboratory for Organic Electronics, LOE. In 2022, a team of scientists led by associate professor Simone Fabiano demonstrated how an artificial organic neuron could be integrated into a living carnivorous plant to control the opening and closing of its maw. This synthetic nerve cell met 2 of the 20 characteristics that differentiate it from a biological nerve cell.