Lifeboat Foundation

Whether cells in the human body survive or die under stress depends, among other things, on their mitochondria. Scientists at the Faculty of Medicine at the University of Freiburg have now shown that a sudden stop in energy production in mitochondria prevents normal cell death or so-called apoptosis and instead triggers an inflammatory response. The results of this research were published in the journal Immunity.

“We found that mitochondria provide a kind of decision-making aid: they regulate whether a cell undergoes clean, silent apoptosis or releases pro-inflammatory messenger substances,” explains Prof. Dr. Olaf Groß, head of the study, a scientist at the Institute of Neuropathology at the Medical Center—University of Freiburg and a member of the Cluster of Excellence CIBSS—Center for Integrative Biological Signaling Studies at the University of Freiburg.

“This finding helps us to better understand how the body maintains a balance between cell protection and defense mechanisms. This could open up new avenues for the treatment of inflammatory diseases.”

Researchers discovered that the mRNA modification m6A triggers rapid degradation, regulating protein production. This breakthrough could inform drug development to manage protein-related diseases.

Messenger ribonucleic acids (mRNA) are like the architects of our bodies. They carry precise blueprints for building proteins, which are read and assembled by their cellular partners, the ribosomes. Proteins are essential for our survival, as they regulate cell division, bolster the immune system, and make our cells resilient against external threats.

Just like in real-world construction, some cellular blueprints require extra instructions—such as when a protein needs to be produced rapidly or when corrections are needed for a flawed design. In our bodies, this role is fulfilled by RNA modifications. These small chemical changes function like detailed annotations, offering additional guidance to specific parts of the mRNA for optimal protein production.

The speed of the human brain’s ability to process information has been investigated in a new study, and according to scientists, we’re not as mentally quick as we might like to think.

In fact, research suggests our brains process information at a speed of just 10 bits per second. But how is this possible, in comparison to the trillions of operations computers can perform every second?

Research suggests this is the result of how we internally process thoughts in single file, making for a slow, congested queue.

A study published in Cell Reports Medicine reveals that bowel movement frequency significantly influences physiology and long-term health, with the best outcomes linked with passing stools once or twice a day.

Previous research has suggested associations between constipation and diarrhea with higher risks of infections and neurodegenerative conditions, respectively.

But since these findings were observed in sick patients, it remained unclear whether irregular bathroom visits were the cause or result of their conditions.

Researchers at the University of Cincinnati College of Medicine and Cincinnati Children’s Hospital have developed a new approach, which combines advanced screening techniques with computational modeling, to significantly shorten the drug discovery process. It has the potential to transform the pharmaceutical industry.

The research, published recently in Science Advances, represents a significant leap forward in drug discovery efficiency. It was featured on LegalReader.com.

https://www.uc.edu/news/articles/2024/09/uc-college-of-medic…aster.html

Continue reading “Legal News, Analysis, & Commentary” »

Elacestrant, also known as Korserdu, will be used to treat a specific kind of breast cancer.

Recent discoveries reveal that bursts of slow pulsing radio waves originate from a binary star system consisting of a red dwarf and a white dwarf.

These findings challenge current pulsar theories and indicate a wider variety of stellar systems may emit similar signals.

Continue reading “Astronomers Finally Solve the Mystery of Strange Repeating Radio Bursts From Space” »

This conference will explore the interdisciplinary interrelations of science, technology and society in addressing the challenges of population aging. By bringing together leading voices in the longevity space and public figures, the Longevity Nation conference will strongly contribute to increasing the synergy of science, technology and aging society, and help advance ethical scientific and technological solutions for healthy longevity for the benefit of the entire society. Building on Israel’s strengths in this area, this conference will help build the supportive longevity ecosystem in Israel, boost the prominence of the field in Israel and enhance Israel’s international standing and cooperation in the Longevity Field. It will help build up longevity R&D and Education support programs, for stakeholders in Israel and international collaborators.

Li, Y.; Hecht, S.S. Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. Int. J. Mol. Sci. 2022, 23, 4559. https://doi.org/10.3390/ijms23094559

AMA Style

Li Y, Hecht SS. Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. International Journal of Molecular Sciences. 2022; 23:4559. https://doi.org/10.3390/ijms23094559