Lifeboat Foundation

When we think about aging, one of the first thoughts that comes to mind is wrinkled and sagging skin as well as the greying and loss of hair – simply put, the physical changes to appearance that we associated with advancing age. These changes are the most striking reflection of the underlying molecular aging processes that are happening inside our bodies.

The current size of the cosmetic industry alone highlights that physical appearance is important to people. As we continue developing strategies to improve longevity allowing us to live longer and in far better health, people will inevitably want a “youthful appearance” to match their newfound “youthful state”. Furthermore, as this report explains in more detail, aesthetic aging plays a significant and grossly underappreciated role in influencing the rate of biological aging.

It is fair to say that the cosmetic industry alone might not be enough to address aesthetic aging from a longevity point of view, as cosmetic products work to conceal the signs of aging. We need tactics that can address the underlying causes of skin and hair aging to achieve long-term benefits and halt the fine interlink between aesthetic aging and biological aging. This is where advanced aesthetics comes in.

Biotech company Mogling Bio has successfully has completed its first seed investment round with a sole investor, Kizoo Technology Capital.

Mogling Bio is developing new pharmacological approaches to rejuvenate old stem cells of the hematopoietic (blood cell formation) system.

Ageing causes stem cells to lose their normal structure by increased activity of the protein CDC42. Normalising CDC42 activity can restore structure, order and functionality in those aged stem cells.

Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro.

Turn.bio, a developer of mRNA-based cellular reprogramming technologies, has announced preliminary results from its current trial. The announcement was made by the company’s co-founder, Prof. Vittorio Sebastiano, at the New Frontiers of RNA Nanotherapeutics conference at Houston Methodist Research Institute. These results show that the company’s proprietary Epigenetic Reprogramming of Aging (ERA) technology greatly increases the fitness of CAR-T cells, which are widely used in modern immunotherapy.

T cell exhaustion is a big problem.

Newly-launched Massachusetts biomanufacturing facility will be something like a conveyor belt from the academic bench to the early startup.

The Aging and Drug Discovery Conference (ARDD) 2022 is pleased to present Alex Zhavoronkov from Insilico, with the talk A case study of the application of Pharma. AI platform for discovery and development of dual-purpose therapeutics targeting aging and disease.

Held in Copenhagen at the glorious Ceremonial Hall, this meeting gathers the most prominent figures of the aging and longevity research field, from scientists to clinicians, investors, developers, and everything in between. The fast growth of the conference is evidence of its great quality of it. In 2022 we had around 400 people on-site, and many others joined through the web.

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While the quantum world is not far away, shrinking down to the size of an atom to experience the quantum realm would be difficult for humans.

A compound that both inhibits the MRSA superbug and renders it more vulnerable to antibiotics in lab experiments has been discovered by researchers at the University of Bath in the UK.

Antibiotic resistance poses a major threat to human health around the world, and Staphylococcus aureus has become one of the most notorious multidrug-resistant pathogens. Led by Dr. Maisem Laabei and Dr. Ian Blagbrough at the University of Bath, scientists have discovered a compound that both inhibits the Methicillin-resistant Staphylococcus aureus (MRSA) superbug and renders it more vulnerable to antibiotics.

Staphylococcus aureus (staph) is a type of bacteria found on people’s skin. Staph bacteria are usually harmless, but they can cause serious infections that can lead to sepsis or death. Methicillin-resistant Staphylococcus aureus (MRSA) is a cause of staph infection that is difficult to treat because of resistance to some antibiotics.

A team of researchers from the National University of Singapore (NUS) have made a serendipitous scientific discovery that could potentially revolutionize the way water is broken down to release hydrogen gas—an element crucial to many industrial processes.

The team, led by Associate Professor Xue Jun Min, Dr. Wang Xiaopeng and Dr. Vincent Lee Wee Siang from the Department of Materials Science and Engineering under the NUS College of Design and Engineering (NUS CDE), found that light can trigger a new mechanism in a catalytic material used extensively in water electrolysis, where water is broken down into hydrogen and oxygen. The result is a more energy-efficient method of obtaining hydrogen.

This breakthrough was achieved in collaboration with Dr. Xi Shibo from the Institute of Sustainability for Chemicals, Energy and Environment under the Agency for Science, Technology and Research (A*STAR); Dr. Yu Zhigen from the Institute of High Performance Computing under A*STAR; and Dr. Wang Hao from the Department of Mechanical Engineering under the NUS CDE.

Lex Fridman Podcast full episode: https://www.youtube.com/watch?v=cdiD-9MMpb0
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GUEST BIO:
Andrej Karpathy is a legendary AI researcher, engineer, and educator. He’s the former director of AI at Tesla, a founding member of OpenAI, and an educator at Stanford.

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