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New Jaw-Dropping Footage From SpaceX Starship 11

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00:00 Starship Landing.

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Engineered “natural killer” cells could help fight cancer

The researchers tested these CAR-NK cells in mice with a human-like immune system. These mice were also injected with lymphoma cells.

Mice that received CAR-NK cells with the new construct maintained the NK cell population for at least three weeks, and the NK cells were able to nearly eliminate cancer in those mice. In mice that received either NK cells with no genetic modifications or NK cells with only the CAR gene, the host immune cells attacked the donor NK cells. In these mice, the NK cells died out within two weeks, and the cancer spread unchecked.

The researchers also found that these engineered CAR-NK cells were much less likely to induce cytokine release syndrome — a common side effect of immunotherapy treatments, which can cause life-threatening complications.

Galvanizing blood vessel cells to expand for organ transplantation

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

Endothelial cells form the inner lining of blood vessels and regulate blood flow, inflammation and healing. Traditional approaches for growing these cells in the lab have yielded only limited numbers before they lose their ability to function. The new method involves treating adult endothelial cells with a small molecule that triggers the hibernating cells to wake up and divide hundreds of times without signs of aging, mutation or loss of function.

The findings, published Oct. 14 in Nature Cardiovascular Research, may provide a reliable way to generate an enormous number of a patient’s own endothelial cells, enabling vascular grafts for , diabetes treatments and and strategies to target abnormal tumor blood vessels.

What is the weak nuclear force and why is it important?

So the weak force doesn’t play by the normal rules — and, in fact, it breaks one of the biggest rules of all.

All of the other forces of nature obey something called parity symmetry. If you run a physics experiment and compare it with the same experiment in the mirror, the results should come out the same.

Mathematical model could help boost drug efficacy by getting dosing in rhythm with circadian clocks

Researchers at the University of Michigan have developed a mathematical model that reveals how our circadian rhythms can have dramatic impacts on how our bodies interact with medicines.

This could help doctors prescribe medicines to have the best intended effect by syncing the dosing up with the natural clocks of their patients.

“These findings provide a mechanistic basis for chronotherapeutics—optimizing drug efficacy by considering circadian timing,” said the new study’s author Tianyong Yao, an undergraduate researcher in the U-M Department of Mathematics. “This could improve treatment for conditions such as ADHD, depression and fatigue.”

Can we hear gravitational-wave ‘beats’ in the rhythm of pulsars?

Pulsars suggest that ultra–low-frequency gravitational waves are rippling through the cosmos. The signal seen by international pulsar timing array collaborations in 2023 could come from a stochastic gravitational-wave background—the sum of many distant sources—or from a single nearby binary of supermassive black holes.

To tell these apart, Hideki Asada, and Professor at Hirosaki University, and Shun Yamamoto, researcher at the Graduate School of Science and Technology, Hirosaki University, propose a method that exploits beat phenomena between gravitational waves at nearly the same frequency, searching for their imprint in the tiny shifts of pulsars’ radio-pulse arrival times.

Their work has been published in the Journal of Cosmology and Astroparticle Physics.

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