Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 299

Vaccines have advanced the field of health and medicine throughout the last century. They are commonly given before a disease can occur to expose individuals to invading pathogens. Vaccines given as a preventative treatment helps the immune system build an immune response against disease that the person may encounter in the future. When an individual gets a shot at the doctor’s office they are injecting an attenuated version of the disease. The body will then recognize this pathogen as foreign and build an immune response against it. This is why many times a person feels sick after a few days from a vaccination – the body is activating the immune system to eliminate the disease.

Many types of vaccines exist and are developed to optimize delivery of attenuated pathogen. Arguably, the most well-known type of vaccine uses messenger ribonucleic acid (mRNA). These vaccines work by delivering mRNA of a virus, which allows human cells to produce viral protein. The immune system responds strongly to the viral proteins and targets them with different immune cells, while also generating antibodies against it. Once the body has built this response, the immune system can more easily target the same virus in the future. This recognition of specific infections is referred to as immunological memory. Currently, the only mRNA vaccines Food and Drug Administration (FDA) approved are for COVID-19. However, the efficient use of mRNA vaccines for COVID-19 have scientists wondering if this format can be used in other disease settings, including cancer.

A recent article in Nature Communications, by Dr. Damya Laoui and others introduce a novel therapeutic approach in which mRNA is integrated into nanoparticles to overcome tumor progression. Laoui is a group leader at Vlaams Instituut voor Biotechnologie (VIB) in Brussels, Belgium. Her work focuses on immune cell activation through specific immune cells known as macrophages and dendritic cells. Laoui also works on developing novel personalized immunotherapies for patients with hard-to-treat cancers.

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Researchers think certain common viruses may trigger some autoimmune conditions—alone or in concert with other factors. A recent Office of Autoimmune Disease Research (OADR)-Office of Research on Women’s Health Science Talks series focused on understanding the triggers of autoimmunity and advancing research.

Almost 80 percent of people living with an autoimmune disease are women. It’s estimated there are 80–120 autoimmune diseases. These chronic and often debilitating diseases have no known cures. Some combination of genetics, immune regulation and the environment work together to form an “endotype” for each autoimmune disease patient, explained Dr. Judith James of the Oklahoma Medical Research Foundation.

Her presentation focused on lupus, or systemic lupus erythematosus (SLE), which disproportionately affects women. Nine women are diagnosed with SLE for every male. In SLE, the immune system attacks healthy tissue, causing inflammation and occasionally permanent damage.

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This study identifies a molecular mechanism promoting fruit shape variation. Local meristem identity is maintained through autoregulatory activation of the STM gene to allow post-fertilization changes in fruit morphology.

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Sea mammal expert Dr Julie Oswald, of the University of St Andrews’ Scottish Oceans Institute, created the tool, known as the Real-time Odontocete Call Classification Algorithm (Rocca), using AI.

It can categorise dolphin calls by species and comes in different versions linked to different geographical areas.

There are around 42 species of dolphin and they use hundreds of different sounds to communicate.

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Chondritic meteorites (chondrites) are some of the oldest rocks in our solar system, forming 4.5 billion years ago. Therefore, their primitive composition means that they offer a window into the origins of planet formation, particularly as their major elements (heavier than hydrogen and helium, including oxygen, silicon, magnesium, iron and nickel) closely reflect the sun’s photosphere composition.

Melting and clumped accumulation (accretion) of at high temperatures (up to 2,000 Kelvin [~1,727 °C]) in the formed crystallized silicate spheres known as chondrules, which further joined together to produce asteroids, the remnants of planetary genesis.

There are two main types, believed to have formed in the inner and outer solar system respectively: ordinary chondrites are composed of up to 90% chondrules, while carbonaceous chondrites have only 20–50% chondrules within a background matrix.

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