Lifeboat Foundation

Caltech researchers discovered an enzyme that enables viral vectors to cross the blood-brain barrier, potentially aiding brain disorder drug development and research.

The blood–brain barrier (BBB) is a stringent, nearly impenetrable layer of cells that guards the brain, protecting the vital organ from hazards in the bloodstream such as toxins or bacteria and allowing only a very limited set of small molecules, such as nutrients, to pass through. This layer of protection, however, makes it difficult for researchers to study the brain and to design drugs that can treat brain disorders.

Now, a new study from Caltech has identified a previously unknown mechanism by which certain viral vectors—protein shells engineered to carry various desired cargo—can cross through the BBB. This mechanistic insight may provide a new approach to designing viral vectors for research and therapeutic applications. Understanding this and other new mechanisms could also give insight into how the brain’s defenses may be exploited by emergent pathogens, enabling researchers to prepare methods to block them.

This new solid hydrogen phase discovered by an international team of researchers followed the model’s presentation of hydrogen molecules under extreme conditions: to use a food analogy, their shape morphed from spheres stacked like a pile of oranges to something that more closely resembled eggs.

Hydrogen typically requires very low temperatures and very high pressures to form a solid. It was through a novel machine learning study of this particular phase change that the scientists came across the new molecular arrangement.

You won’t exactly see through any barrier like Superman, but by using this AR headset, you could locate items buried away in a giant warehouse.

ChatGPT has been hitting the headlines since its debut and after passing exams at business and law schools. Now, most recently, the AI has nearly passed the US Medical Licensure Exam (USMLE) necessary to pursue medical practice within the US.

ChatGPT: Revolutionary AI

Continue reading “AI Doctor? ChatGPT Nearly Passes US Medical Licensing Exam” »

The potential new mineral was discovered in a chunk of “fossilized lightning,” or fulgurite, that was left behind when a tree in Florida was struck by lightning.

Ways to think about generative AI as a co-creator.

Researchers named the newfound species Tripedalia maipoensis, after Mai Po Nature Reserve in Hong Kong, where they discovered the transparent critter.

Suppose a large inbound asteroid were discovered, and we learned that half of all astronomers gave it at least 10% chance of causing human extinction, just as a similar asteroid exterminated the dinosaurs about 66 million years ago. Since we have such a long history of thinking about this threat and what to do about it, from scientific conferences to Hollywood blockbusters, you might expect humanity to shift into high gear with a deflection mission to steer it in a safer direction.

Sadly, I now feel that we’re living the movie “Don’t look up” for another existential threat: unaligned superintelligence. We may soon have to share our planet with more intelligent “minds” that care less about us than we cared about mammoths. A recent survey showed that half of AI researchers give AI at least 10% chance of causing human extinction. Since we have such a long history of thinking about this threat and what to do about it, from scientific conferences to Hollywood blockbusters, you might expect that humanity would shift into high gear with a mission to steer AI in a safer direction than out-of-control superintelligence. Think again: instead, the most influential responses have been a combination of denial, mockery, and resignation so darkly comical that it’s deserving of an Oscar.

Continue reading “The ‘Don’t Look Up’ Thinking That Could Doom Us With AI” »

A woman could have her fallopian tubes removed for any number of reasons. Sometimes, it’s necessary to treat an ectopic pregnancy or to resolve an infection caused by pelvic inflammatory disease. In other cases, it’s done as a form of permanent birth control.

But a growing body of evidence suggests that the distal fallopian tube — or flower-shaped section located nearest the ovary — is the site of many cases of high-grade serous ovarian cancer, the most common type of ovarian cancer and one of the most aggressive.

Research also suggests that an opportunistic salpingectomy — the complete removal of the fallopian tubes during an unrelated pelvic surgery — could help reduce the chances of one day developing ovarian cancer.