Lifeboat Foundation

Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications. The work appears in the journal Small this month.

When we think of DNA, the first association that comes to mind is likely genetics—the double helix structure within cells that houses an organism’s blueprint for growth and reproduction. A rapidly evolving area of DNA research is that of DNA nanostructures—synthetic molecules made up of the same building blocks as the DNA found in living cells, which are being engineered to solve critical challenges in applications ranging from medical diagnostics and drug delivery to materials science and data storage.

“In this work, we assembled DNA nanostructures without using magnesium, which is typically used in this process but comes with challenges that ultimately reduce the utility of the nanostructures that are produced,” said Arun Richard Chandrasekaran, corresponding author of the study and senior research scientist at the RNA Institute.

Previous morpho-molecular studies of evolutionary relationships within the economically important genus of honey bees (Apis), including the Western Honey Bee (A. mellifera L.), have suggested Out of Africa or Asia origins and subsequent spread to Europe. I test these hypotheses by a meta-analysis of complete mitochondrial DNA coding regions (11.0 kbp) from 22 nominal subspecies represented by 78 individual sequences in A. mellifera. Parsimony, distance, and likelihood analyses identify six nested clades: Things Fall Apart with Out of Africa or Asia hypotheses. Molecular clock-calibrated phylogeographic analysis shows instead a basal origin of A. m. mellifera in Europe ~ 780 Kya, and expansion to Southeast Europe and Asia Minor ~ 720 Kya. Eurasian bees spread southward via a Levantine/Nilotic/Arabian corridor into Africa ~ 540 Kya.

Something had to diverge from the trunk eventually.

Las Vegas police officers investigated reports of two unknown entities falling from the sky on the same night in late April that a family reported something ‘not human’ in their backyard.

One officer drove to a home on the night of April 30 and interviewed the family who called 911 after making the sighting, according to body camera footage obtained by USA TODAY. One of the family members told the officer they saw “a big creature” that was “long, 10 feet tall.”

The officer told the family he was looking into the claims because another officer saw something in the sky that matched the family’s description eight minutes earlier.

A new study looks at people’s views of kindness, respect and honesty around the world and over seven decades.

To despair over oneself, in despair to want to be rid of oneself, is the formula for all despair.

Down beneath the tourist lodges and shops selling keychains and incense, past windswept arroyos and brown valleys speckled with agave, juniper and sagebrush, the rocks of the Grand Canyon seem untethered from time. The oldest ones date back 1.8 billion years, not just eons before humans laid eyes on them, but eons before evolution endowed any organism on this planet with eyes.

Spend long enough in the canyon, and you might start feeling a little unmoored from time yourself. The immense walls form a kind of cocoon, sealing you off from the modern world, with its cell signal and light pollution and disappointments. They draw your eyes relentlessly upward, as in a cathedral.

You might think you are seeing all the way to the top. But up and above are more walls, and above them even more, out of sight except for the occasional glimpse. For the canyon is not just deep. It is broad, too — 18 miles, rim to rim, at its widest. This is no mere cathedral of stone. It is a kingdom: sprawling, self-contained, an alternate reality existing magnificently outside of our own.

Spiral

Actuators inspired by cucumber plants could make robots move more naturally in response to their environments, or be used for devices in inhospitable places.