Lifeboat Foundation

There’s a bouncer in everyone: The blood-brain barrier, a layer of cells between blood vessels and the rest of the brain, kicks out toxins, pathogens and other undesirables that can sabotage the brain’s precious gray matter.

When the bouncer is off its guard and a rowdy element gains entry, a variety of conditions can crop up. Barrier-invading cancer cells can develop into tumors, and multiple sclerosis can occur when too many white blood cells slip pass the barrier, leading to an autoimmune attack on the protective layer of brain nerves, hindering their communication with the rest of the body.

“A leaky blood-brain barrier is a common pathway for a lot of brain diseases, so to be able to seal off the barrier has been a long sought-after goal in medicine,” said Calvin Kuo, MD, PhD, the Maureen Lyles D’Ambrogio Professor and a professor of hematology.

Cedars-Sinai investigators have identified several steps in a cellular process responsible for triggering one of the body’s important inflammatory responses. Their findings, published in the journal Science Immunology, open up possibilities for modulating the type of inflammation associated with several infections and inflammatory diseases.

Specifically, the investigators have improved understanding of the steps that lead to the production of IL-1 beta, a potent inflammatory protein signal released during many inflammatory responses.

“We now have a clearer understanding of the stepwise process that leads to the production of IL-1 beta,” said Andrea Wolf, Ph.D., assistant professor of Biomedical Sciences and Medicine at Cedars-Sinai, and a senior and corresponding author on the new study. “By understanding the process, we hope to one day find a treatment for diseases associated with this inflammatory response.”

Learn about the heart and and how it works from WebMD.

A rare, half-billion-year-old fossil gives us a clue to how a bizarre marine invertebrate can possibly be related to humans. In a study published on July 6 in the journal Nature Communications, Harvard University researchers identified a prehistoric specimen in a collection at the Natural History Museum of Utah as a tunicate, or sea squirt. The preserved invertebrate, which was originally discovered in the rugged, desert-like landscape of the House Range in western Utah, can be used to understand evolution mysteries that go way back to the Cambrian explosion.

“There are essentially no tunicate fossils in the entire fossil record. They’ve got a 520-to 540-million year-long gap,” says Karma Nanglu, an invertebrate paleontologist at Harvard. “This fossil isthe first soft-tissue tunicate in, we would argue, the entire fossil record.”

Sea squirts can be seen swaying on the ocean floor with its potato-like body and two chimney-like parts called siphons that are used to feed and expel water. While there are at least 3,000 different species today, the crayon-point-size organisms are generally unknown to people—despite being our invertebrate cousins, says Nanglu. Like humans, they belong to the chordates, which share five essential physical features during development or when fully grown. Most tunicates hatch as swimming, tadpole-like creatures, but eventually attach to the ocean floor and lead a sessile lifestyle.

AI has gotten good at writing. Here’s how experts say you can identify it.

It’s estimated that humans are producing the equivalent of 10 million Blu-ray Discs of data per day – and all and zero of those have to be stored somewhere.

Now, UK researchers may have a solution: a five-dimensional (5D) digital data disc that can store 360 terabytes of data for about 13.8 billion years.

To create the data discs, scientists at the University of Southampton used a process called femtosecond laser writing, which creates tiny discs of glass using ultrafast lasers that generate short and intense pulses of light.

Brain tissue is one of the most intricate tissue specimens that scientists have arguably ever dealt with. Packed with an immeasurable amount of information, the human brain is the most sophisticated computational device with its network of around 86 billion neurons.

Understanding such complexity is a difficult task, and therefore making progress requires technologies to unravel the tiny, complex interactions taking place in the brain at microscopic scales. Imaging is therefore an enabling tool in neuroscience.

Continue reading “Large collaboration yields unprecedented ‘live’ view into the brain’s complexity” »

Digital art techniques can now devise custom, working biomolecules on demand.

Summary: A novel study suggests that silence can indeed be ‘heard.’ Philosophers and psychologists, using auditory illusions, demonstrated how silence distorts our perception of time, much like sounds do.

The study indicates that the brain perceives and processes silence in a manner similar to sounds. The research establishes a novel method to study the perception of absence, broadening the scope for future exploration in the realm of sensory perception.