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Man arrested for demanding reward after accidental police data leak

Dutch authorities arrested a 40-year-old man after he downloaded confidential documents that had been mistakenly shared by the police and refused to delete them unless he received “something in return.”

Police detained the suspect at his Prinses Beatrixstraat residence in Ridderkerk on Thursday evening for computer hacking after the failed “extortion” attempt, searching his home and seizing data storage devices to recover the files.

The incident began when the man contacted police on February 12 about images he had that may be relevant to an ongoing investigation. An officer responded to his inquiry but, instead of sending a link to upload the images, mistakenly shared a download link to confidential police documents.

SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity

Zhong et al. demonstrate that SREBP-1 and SOAT1 are co-upregulated in GBM and NSCLC, coupling cholesterol acquisition and storage. They reveal that SREBP-1 transcriptionally activates SOAT1, enabling cancer cells to sustain cholesterol homeostasis, and that targeting SOAT1 disrupts this balance, leading to ROS accumulation, mitochondrial dysfunction, and tumor cell death.

A drug to cure jet lag?

Adapting to eastward travel, such as west-to-east transmeridian flights, or to night-shift work requires advancing the internal clock, a process that normally takes longer and is physiologically harder than delaying it.

Existing methods, such as light therapy or melatonin, are heavily constrained by timing and often yield inconsistent results.

Mic-628’s consistent phase-advance effect, regardless of when it is administered, represents a new pharmacological strategy for resetting the circadian clock.

The researchers discovered that Mic-628 selectively induces the mammalian clock gene Per1.

Mic-628 works by binding to the repressor protein CRY1, promoting the formation of a CLOCK–BMAL1–CRY1–Mic-628 complex that activates Per1 transcription through a “dual E-box” DNA element.

As a result, both the central clock in the brain’s suprachiasmatic nucleus (SCN) and peripheral clocks in tissues such as the lungs were advanced—in tandem and independent of dosing time.

In a simulated jet lag mouse model (6-hour light-dark phase advance), a single oral dose of Mic-628 shortened re-entrainment time from seven days to four.

Continue reading “A drug to cure jet lag?” | >

Scientists confirm one-dimensional electron behavior in phosphorus chains

For the first time, researchers have shown that self-assembled phosphorus chains can host genuinely one-dimensional electron behavior. Using advanced imaging and spectroscopy techniques, they separated the signals from chains aligned in different directions to reveal their true nature. The findings suggest that squeezing the chains closer together could trigger a dramatic shift from semiconductor to metal. That means simply adjusting density could unlock entirely new electronic states.

3D-weaving tech that uses body-scan data from shoppers could mean a better fit, fewer returns, and a zero-waste future for fashion

3D-printed designs and 3D-woven clothing by tech startup Unspun hints at what the fashion industry’s sustainable, zero-waste future could look like.

Levi’s® Tests 3D Printing Technology

Over 50 years ago, the classic Levi’s® Trucker jacket was introduced. But we are not one to rest on past accomplishments.

Now, the brand is turning to futuristic modes of innovation in manufacturing, pioneering a new approach in denim design.

Fast Company joined Levi’s® Head of Global Product Innovation, Paul Dillinger, at the Autodesk Pier 9 Workshop in San Francisco to witness how Levi’s® has been experimenting with 3D printing, creating digital renderings of the denim jacket which is essentially a shell of what the “real” thing could look like.

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