Last week’s cyberattack on medical technology giant Stryker was limited to its internal Microsoft environment and remotely wiped tens of thousands of employee devices.
The organization says in an update on Sunday that all its medical devices are safe to use but electronic ordering systems remain offline, and customers must place orders manually through sales representatives.
Stryker emphasizes that the incident was not a ransomware attack and that the threat actor did not deploy any malware on its systems.
Microsoft is working to address an ongoing Exchange Online outage that is preventing customers from accessing their mailboxes and calendars.
“We’re investigating reports of some users experiencing issues when accessing their Exchange Online mailbox via one or more connection methods,” Microsoft said when it acknowledged the issue at 06:42 AM UTC.
As Microsoft explained in a Microsoft 365 admin center update under EX1253275, Outlook on the web, Outlook desktop, Exchange ActiveSync, and other Exchange Online connection protocols are all affected by this outage.
Does the universe need observers to exist? Neil deGrasse Tyson and co-hosts Chuck Nice and Gary O’Reilly explore questions about entropy, spontaneous symmetry breaking, spectroscopy and more with astrophysicist Charles Liu.
Does the universe require observers for information to exist? From Niels Bohr and the Copenhagen interpretation to modern neuroscience and philosophy, the crew explores whether measurement creates reality or reveals it. How does the double-slit experiment fit into this? Are wave and particle behaviors determined by how we measure them?
The conversation turns to information itself. What do physicists mean by “information”? How is entropy connected to hidden information in a system? We discuss entropy through everyday examples like coin flips, burning wood, and boiling water. How does this relate to quantum computing? We explore how astronomers separate cosmic redshift from stellar motion using spectroscopy, how interstellar dust and extinction curves complicate observations, and why mapping that dust is both a challenge and a source of discovery.
We discuss why the Big Bang didn’t form a black hole, how spontaneous symmetry breaking may have split the fundamental forces, and whether science can meaningfully investigate the universe’s earliest moments. Wrapping up, the team looks ahead to multi-messenger astronomy, next-generation telescope technology, exotic ideas about the speed of light, and how information continues to reshape what we know about the cosmos.
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Timestamps:
Matter. What is reality? And if it’s so fundamental, why do we all experience it so differently? Join us for a marathon through the discoveries and paradoxes that suggest modern physics is pointing to a deeply uncomfortable truth: that our picture of the universe is far from complete, and what we think about reality may be completely wrong.
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00:00 Reality Is Already Broken
00:57 Scientists Build a Window into the Fourth Dimension
23:16 The Physicist Who Says Reality Is Not What It Seems
1:28:45 The Black Hole Paradox That Keeps Physicists Awake at Night
1:50:40 Sean Carroll: The Many Worlds of Quantum Mechanics
2:46:40 What are the foundations of reality?
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Astrocyte-microglia crosstalk in thalamocortical synapse refinement.
Both microglia and astrocytes play crucial role in synapse refinement during development but it is not clear how they communicate to balance synapse formation and elimination.
The researchers show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1.
The proteolytically generated C-terminal of Hevin signals to microglia via TLR4, triggering a pro-phagocytic state that promotes refinement of thalamocortical synapses in the developing visual cortex. sciencenewshighlights ScienceMission https://sciencemission.com/Hevin-and-Toll-like-receptor
Microglia are key drivers of synapse refinement during development. Ramirez et al. show that astrocytes instruct this process through the secreted synaptogenic protein Hevin/Sparcl1. The proteolytically generated C-terminal of Hevin signals to microglia via TLR4, triggering a pro-phagocytic state that promotes refinement of thalamocortical synapses in the developing visual cortex.
Online now: Jia et al. delineate the most comprehensive plasma proteomic landscape of frailty to date and develop proteomic frailty scores that predict multiple diseases and respond to modifiable risk factors. They identify a biphasic pattern of frailty-related proteomic alterations across the lifespan, revealing critical windows that may inform targeted intervention programs.
This study demonstrates that the FDA-approved drug 18AA potently resensitizes multidrug-resistant pathogens to ceftazidime-avibactam. It achieves this by activating two bacterial pathways, the inosine-CusS/R-CusC axis and the proton motive force, to promote antibiotic influx, offering a readily translatable strategy against formidable infections.
“When engineering a computer, you need to know the circuitry of the central processing unit. If you don’t know how everything is wired together, you can’t understand its function, optimize it or fix it when something breaks. We are approaching the brain the same way,” said study leader Boxuan Zhao, a professor of cell and developmental biology at the University of Illinois Urbana-Champaign.
“Our technology enables simultaneous mapping of thousands of neural connections with single-synapse resolution —a capability that doesn’t exist in any current technology. It is directly applicable to understanding circuit dysfunction in neurodegenerative diseases and could provide a platform for developing circuit-guided therapeutic interventions,” he said.