Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 138

We are in the noisy intermediate-scale quantum (NISQ) devices’ era, in which quantum hardware has become available for application in real-world problems. However, demonstrations of the usefulness of such NISQ devices are still rare. In this work, we consider a practical railway dispatching problem: delay and conflict management on single-track railway lines. We examine the train dispatching consequences of the arrival of an already delayed train to a given network segment. This problem is computationally hard and needs to be solved almost in real time. We introduce a quadratic unconstrained binary optimization (QUBO) model of this problem, which is compatible with the emerging quantum annealing technology. The model’s instances can be executed on present-day quantum annealers.

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Cephalopods’ remarkable behavior and complex neurobiology make them valuable comparative model organisms, but studies aimed at enhancing welfare of captive cephalopods remain uncommon. Increasing regulation of cephalopods in research laboratories has resulted in growing interest in welfare-oriented refinements, including analgesia and anesthesia. Although general and local anesthesia in cephalopods have received limited prior study, there have been no studies of systemic analgesics in cephalopods to date. Here we show that analgesics from several different drug classes may be effective in E. berryi. Buprenorphine, ketorolac and dexmedetomidine, at doses similar to those used in fish, showed promising effects on baseline nociceptive thresholds, excitability of peripheral sensory nerves, and on behavioral responses to transient noxious stimulation.

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Tohoku University scientists created lab-grown neural networks using microfluidic devices, mimicking natural brain activity and enabling advanced studies of learning and memory.

The phrase “Neurons that fire together, wire together” encapsulates the principle of neural plasticity in the human brain. However, neurons grown in a laboratory dish do not typically adhere to these rules. Instead, cultured neurons often form random, unstructured networks where all cells fire simultaneously, failing to mimic the organized and meaningful connections seen in a real brain. As a result, these in-vitro models provide only limited insights into how learning occurs in living systems.

What if, however, we could create in-vitro neurons that more closely replicate natural brain behavior?

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Princeton engineers have developed a scalable 3D printing technique to produce soft plastics with customizable stretchiness and flexibility, while also being recyclable and cost-effective—qualities rarely combined in commercially available materials.

In a study published in Advanced Functional Materials, a team led by Emily Davidson detailed how they used thermoplastic elastomers—a class of widely available polymers—to create 3D-printed structures with adjustable stiffness. By designing the 3D printer’s print path, the engineers could program the plastic’s physical properties, allowing devices to stretch and flex in one direction while remaining rigid in another.

Davidson, an assistant professor of chemical and biological engineering, highlighted the potential applications of this technique in fields such as soft robotics, medical devices, prosthetics, lightweight helmets, and custom high-performance shoe soles.

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Researchers are warning of potential risks from the development of synthetic organisms called mirror bacteria, which have reversed molecular chirality.

These organisms could evade immune systems, disrupt natural ecosystems, and pose threats to human, animal, plant, and environmental health.

Potential Risks of Mirror Bacteria.

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NASA and SpaceX have rescheduled the launch of the IMAP spacecraft to September 2025 to allow more time for preparing its flight systems.

The mission will explore the heliosphere to understand the Sun’s protective bubble and its effects on space weather and life. Accompanying IMAP are two rideshare missions: the Carruthers Geocorona Observatory and NOAAs Space Weather Follow On – Lagrange 1, which will study Earth’s outer atmosphere and monitor solar activity, respectively. All three spacecraft will operate from Lagrange point 1 to efficiently monitor space conditions.

IMAP launch delay and mission overview.

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Stanford Medicine researchers have developed a new method for influenza vaccination that encourages a robust immune response to all four common flu subtypes, potentially increasing the vaccine’s efficacy.

In laboratory tests using human tonsil organoids, the modified vaccine showed promising results in combating both seasonal and bird flu strains. The approach involves a combined antigen methodology that might also protect against emerging flu variants with pandemic potential.

Innovative Flu Vaccine Development

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NUS researchers found that deuterated water (D₂O) reduces pain by modulating the TRPV1 ion channel, offering a non-addictive alternative to conventional painkillers.

Researchers from the National University of Singapore (NUS), in partnership with Peking University, China, have uncovered new insights into the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception. Their findings demonstrate how solvent molecules can influence pain signals, paving the way for potential development of safer, non-addictive pain management strategies.

Effective pain management is vital for improving quality of life and overall well-being. The TRPV1 ion channel, which plays a key role in detecting pain, expands its pore when activated, enabling ions and larger molecules to pass through. However, the ability of water molecules to permeate the TRPV1 channel has remained uncertain.

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