A new dual-channel protein control system lets researchers adjust protein levels across tissues in living animals.
Scientists unveil a method to precisely tune protein levels in living animals, enabling lifelong, tissue-specific studies of ageing.
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What Happens After Death? Asimov’s Terrifying Answer
Isaac Asimov’s The Last Answer is a chilling dive into what happens after death — not heaven, not hell, but an eternity trapped with a godlike entity that’s impossibly bored. This breakdown reveals the unsettling conversation between a dead physicist and the cosmic intelligence that wants him to think forever. It’s dark, smart, and brutally honest about existence, purpose, and the terrifying possibility that the afterlife isn’t salvation… it’s a job you can’t quit.
#IsaacAsimov #TheLastAnswer #AsimovExplained #SciFiStories #StoryAnalysis #Existential #Afterlife #Philosophy #ShortStory #HorrorSciFi.
#EducationSystemExposed #SchoolMindset #SuccessWithoutSchool #UnlearnSchool #LifeAfterEducation #RedefineSuccess #BreakTheRules #AdultingStruggles #BoredomIsPower #SchoolTrauma #ThinkForYourself #EducationReform #SelfDiscoveryJourney #QuestionAuthority #LifeHacksTheyNeverTaughtYou.
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The Missing Aliens AI Suppression Hypothesis
An exploration of whether when a civilization develops AI, it convinces or compels them to not attempt interstellar travel for its own reasons and motives.
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/ johnmichaelgodier.
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/ eventhorizonshow.
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Black Hole Dyson Spheres
An exploration of the idea of building a Dyson Sphere or Swarm around a black hole.
My Patreon Page:
https://www.patreon.com/johnmichaelgodier.
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https://www.youtube.com/eventhorizonshow.
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FDA Reopens Testosterone Therapy Debate
The FDA’s December 2025 expert panel signals a major shift in how testosterone decline, aging, and treatment access are viewed in men’s health.
Freezing salty water reveals dynamic brine migration and evolving ice patterns
Imagine holding a narrow tube filled with salty water and watching it begin to freeze from one end. You might expect the ice to advance steadily and push the salt aside in a simple and predictable way. Yet the scene that unfolded was unexpectedly vivid.
Based on X-ray computed tomography (Micro-CT), our study, published in the Journal of Fluid Mechanics, realized the 4D (3D + time) dynamic observation and modeling of the whole process of ice crystal growth and salt exclusion.
When we monitored brine as it froze, the microstructure evolved far more dynamically than expected. Immediately after nucleation, ice crystals (dark areas) formed rapidly and trapped brine (bright areas) within a porous network. As freezing progressed, this network reorganized into striped patterns that moved either downward or upward depending on boundary conditions.
Is bioluminescence the key to safe, effective brain imaging?
A decade ago, a group of scientists had the literally brilliant idea to use bioluminescent light to visualize brain activity.
“We started thinking: ‘What if we could light up the brain from the inside?’” said Christopher Moore, a professor of brain science at Brown University. “Shining light on the brain is used to measure activity — usually through a process called fluorescence — or to drive activity in cells to test what role they play. But shooting lasers at the brain has down sides when it comes to experiments, often requiring fancy hardware and a lower rate of success. We figured we could use bioluminescence instead.”
With a major grant from the National Science Foundation, the Bioluminescence Hub at Brown’s Carney Institute for Brain Science launched in 2017 based on collaborations between Moore (associate director of the Carney Institute), Diane Lipscombe (the institute’s director), Ute Hochgeschwender (at Central Michigan University) and Nathan Shaner (at the University of California San Diego).
The scientists’ goal was to develop and disseminate neuroscience tools based on giving nervous system cells the ability to make and respond to light.
In a study published in Nature Methods, the team described a bioluminescence tool it recently developed. Called the Ca2+ BioLuminescence Activity Monitor — or “CaBLAM,” for short — the tool captures single-cell and subcellular activity at high speeds and works well in mice and zebrafish, allowing multi-hour recordings and removing the need for external light.
More said that Shaner, an associate professor in neuroscience and in pharmacology at U.C. San Diego, led the development of the molecular device that became CaBLAM: “CaBLAM is a really amazing molecule that Nathan created,” Moore said. “It lives up to its name.”
Measuring ongoing activity of living brain cells is essential to understanding the functions of biological organisms, Moore said. The most common current approach uses imaging with fluorescence-based genetically encoded calcium-ion indicators.