Lifeboat Foundation

Sharing for fellow researchers and others who have interest in GBM news.

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment given its potential to specifically target tumor tissue while sparing the normal brain. However, the diffuse and infiltrative nature of these tumors in the brain parenchyma may pose an exceptional hurdle to successful immunotherapy in patients. Areas of invasive tumor are thought to reside behind an intact blood brain barrier, isolating them from effective immunosurveillance and thereby predisposing the development of “immunologically silent” tumor peninsulas. Therefore, it remains unclear if adoptively transferred T cells can migrate to and mediate regression in areas of invasive GBM. One barrier has been the lack of a preclinical mouse model that accurately recapitulates the growth patterns of human GBM in vivo. Here, we demonstrate that D-270 MG xenografts exhibit the classical features of GBM and produce the diffuse and invasive tumors seen in patients. Using this model, we designed experiments to assess whether T cells expressing third-generation chimeric antigen receptors (CARs) targeting the tumor-specific mutation of the epidermal growth factor receptor, EGFRvIII, would localize to and treat invasive intracerebral GBM. EGFRvIII-targeted CAR (EGFRvIII⁺ CAR) T cells demonstrated in vitro EGFRvIII antigen-specific recognition and reactivity to the D-270 MG cell line, which naturally expresses EGFRvIII. Moreover, when administered systemically, EGFRvIII⁺ CAR T cells localized to areas of invasive tumor, suppressed tumor growth, and enhanced survival of mice with established intracranial D-270 MG tumors. Together, these data demonstrate that systemically administered T cells are capable of migrating to the invasive edges of GBM to mediate antitumor efficacy and tumor regression.

Glioblastoma (GBM) is the most common form of primary malignant brain tumor in adults and remains one of the most deadly neoplasms. Despite multimodal therapy including maximal surgical resection, radiation, and temozolomide (TMZ), the median overall survival is less than 15 months [1]. Moreover, these therapies are non-specific and are ultimately limited by toxicity to normal tissues [2]. In contrast, immunotherapy promises an exquisitely precise approach, and substantial evidence suggests that T cells can eradicate large, well-established tumors in mice and humans [3] –[7].

Continue reading “EGFRvIII-Specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma” »

I believe Richard Feynman was one of our greatest scientific minds. He had a very particular way of looking at the world thanks to his father, and it was to look at the world around him as if he were a Martian. Like a fish born into water, it’s hard to actually see water as being water, because it’s all a fish ever knows. And so as humans, it’s a good idea to try and step outside of our usual frame of mind, to see what it is we as humans think and do, from the perspective of a mind totally alien to our everyday environment. With that in mind, here’s what humans are doing right now, from the perspective of someone from far, far away…

What an interesting place and an interesting time it is for a visit. Earth’s most intelligent primates are busy creating technologies that allow them all to do less work, freeing themselves from millennia of senseless toil and drudgery. Strangely, however, they are using such technologies to force each other to work longer and harder. In one area called the United States, responsible for so much of the world’s technological innovation, at a time when productivity has never been higher, the number of hours spent working for others in exchange for the means to live is now just shy of 50 hours per week, where it was once 40 and soon supposed to be 20 on its way to eventually approaching zero.

Humans are even performing work that doesn’t actually need to be done at all, even by a machine. One of the craziest examples of such completely unnecessary work is in Europe where an entire fake economic universe has been created under the label of “Potemkin companies” like Candelia.

Continue reading “Here’s Why A Universal Basic Income Is The Key To Human Progress” »

A simple blood test can rapidly and accurately detect mutations in two key genes in non-small cell lung tumors, researchers at Dana-Farber Cancer Institute and other institutions report in a new study – demonstrating the test’s potential as a clinical tool for identifying patients who can benefit from drugs targeting those mutations.

Nice

The army wants a star trek-like universal translator — and wants IBM to build it.

Travel the world. See strange and distant lands. Then invade them.

Continue reading “The Army Wants a Star Trek-Like Universal Translator -- and Wants IBM to Build It” »

The Defense Advanced Research Projects Agency is looking to take its own swing at an encrypted messaging app.

April 22, 2016.

The Defense Information Systems Agency, like many other federal agencies and the Defense Department as a whole, is bullish on embracing the small, innovative startups popping up in private sector, particularly Silicon Valley. But finding a way to integrate those fast-moving startups into DISA’s rules-encumbered procurement process remains a major hurdle.

The creative acronym – SILMARILS – comes from “Lord of the Ring’s” magical lore. IARPA’s goals for the project are anything but fictional.

Current technologies for detecting narcotics, explosives and other dangerous chemicals requires physical contact between humans and X-ray-based machinery like those stationed within major airports that scan suitcases and luggage.

In other cases, a human must swab samples of a substance and run them through a similar machine, which is time and labor consuming and risky.

Continue reading “IARPA Wants a Hand-Held Laser Gun That Can Detect Chemicals 100 Feet Away” »

https://youtube.com/watch?v=Al5RhaJgxxU

Pretty cool!

As Brain-Computer Interface is rapidly developed worldwide, mind-controlled drones turn into sports and weapons of today.

Continue reading “Brave New World: Mind-Controlled Drones Revolutionizing Sports And Warfare” »

Nice as long as we get hacking under control.

Brain Computer Interface (BCI) Market — Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 — 2023.

Bringing awareness on a syndrome that makes it hard for families and patients trying to have genetic testing on cancers in their families. I first came across this syndrome with a researcher at Swedish Medical Center’s Cancer Research Group. Some families can have so many various cancers that genetic testing is extremely costly to patients and may not be able to pinpoint the mutation due to this syndrome.

Yet misdiagnosis remains an ongoing challenge, and a recent international study involving more than 100 countries and nearly 2000 patients revealed the average case takes between 5 and 9 years to properly diagnose after the first symptoms appear, and the average patient may see five or six doctors, noted Richard R.P. Warner, MD, in an interview with Oncology Nursing News.

“You can’t detect it, if you don’t suspect it,” said Warner, who directs the Center for Carcinoid and Neuroendocrine Tumors at Mount Sinai Hospital. Most doctors will only see one or two cases in their lifetime, and symptoms of NETs, like diarrhea and recurrent episodes of flushing, are associated with other, more commonly seen conditions.

Continue reading “Understanding Neuroendocrine Tumors and Carcinoid Syndrome” »