Lifeboat Foundation

EPJ — Nonlinear Biomedical Physics is an open access journal, published under the brand SpringerOpen, dedicated to the application of nonlinear dynamics and integrative systems science to the quantitative modeling and understanding of how structure and function as well as dysfunctions and diseases emerge in complex biomedical matter and processes. Coverage is focused on the application-driven development of theoretical, experimental and computational techniques, including relevant methodologies, instrumentation and related advanced technology.

This article originally appeared in the Conversation.

Researchers including George Church have made further progress on the path to fully rewriting the genome of living bacteria. Such a recoded organism, once available, could feature functionality not seen in nature. It could also make the bacteria cultivated in pharmaceutical and other industries immune to viruses, saving billions of dollars of losses due to viral contamination. Finally, the altered genetic information in such an organism wouldn’t be able to contaminate natural cells because of the code’s limitations outside the lab, researchers say, so its creation could stop laboratory engineered organisms from genetically contaminating wildlife. In the DNA of living organisms, the same amino acid can be encoded by multiple codons — DNA “words” of three nucleotide letters. Here, building on previous work that demonstrated it was possible to use the genetic equivalent of “search and replace” in Escherichia coli to substitute a single codon with an alternative, Nili Ostrov, Church and colleagues explored the feasibility of replacing multiple codons, genome-wide. The researchers attempted to reduce the number of codons in the E. coli code from 64 to 57 by exploring how to eradicate more than 60,000 instances of seven different codons. They systematically replaced all 62,214 instances of these seven codons with alternatives. In the recoded E.coli segments that the researchers assembled and tested, 63% of all instances of the seven codons were replaced, the researchers say, and most of the genes impacted by underlying amino acid changes were expressed normally. Though they did not achieve a fully operational 57-codon E. coli, “a functionally altered genome of this scale has not yet been explored,” the authors write. Their results provide critical insights into the next step in the genome rewriting arena — creating a fully recoded organism.

The blog take away: How is the key frequency of beta oxidation made in a mitochondria?Most people believe fat burning via beta oxidation is a fuel mediated mechanism but Dr. Doug Wallace’s data strongly suggests it is linked to the vibration state of the inner mitochondrial membrane. If so, how is the sun’s photoelectric abilities critical to this mechanism in mitochondria? Watch the video in the hyperlink closely from 50:00 – 59:00 for the clue.

Hyperlink

Water surrounds each mitochondria in a cell with its MINOS layer. It is adjacent to the cytochrome 1 complex. Water has a high dielectric constant. It is 78 in bulk water, to be exact, Why is that critical? Well cytochrome one has a redox Fe-S couple that acts like a semiconductor for electrons. Electrons act differently in a semiconductor than they do when they are not captured by one. How much do you know about semiconductor integrated circuits? In a typical network in an integrated circuit, each network will include at least one driver, which must contain a source or drain diffusion and at least one receiver. This set up will consist of a gate electrode over a thin gate dielectric (look for a view of a MOS transistor on line if you’re unsure of this arrangement to get a visual.)

Continue reading “Time #20: is Fat Burning Due to 100 hz Vibration in Mitochondria?” »

Luv this.

MIT biological engineers have devised a way to record complex histories in the DNA of human cells, allowing them to retrieve “memories” of past events, such as inflammation, by sequencing the DNA.

This analog memory storage system—the first that can record the duration and/or intensity of events in human cells—could also help scientists study how cells differentiate into various tissues during embryonic development, how cells experience environmental conditions, and how they undergo genetic changes that lead to disease.

Continue reading “Engineers program human cells to store complex histories in their DNA” »

Ray believes we’re becoming gods.

People tend to ask Ray Kurzweil all manner of questions about technology and the future. But they also want to know about his own personal philosophy. In one session last summer, a questioner asked Kurzweil if he believes in God. Of course, many of us struggle with the question, he replied, and to him, it’s not unambiguous.

Continue reading “Why Ray Kurzweil Believes We Are Becoming More God-Like [Video]” »

I consider myself a collector of sorts. I collect strange, bizarre notions and theories that warp traditional narratives about reality and existence. The following is a presentation of 10 of my favorite mind-blowing theories. There is compelling evidence for each, but you certainly don’t – and, for the sake of your sanity, probably shouldn’t – need to take them as gospel.

1. The Singularity: We will transcend biology and live as posthuman Gods.

SOMEONE over at the NSA has a date with a small, windowless cell in a deep dark hole in the ground in their near future, me thinks.

Hacking tools — possibly belonging to the NSA — have been leaked and are now accessible to common criminal hackers.

A123 and SolidEnergy are collaborating on development of a new electrolyte technology that enables lithium-ion battery designs with 4 times the energy density of today’s technology.

A123 Systems Jeff Kessen, 734.772.0345 [email protected]