Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: science – Page 129

Orginal press: http://www.prweb.com/releases/2017/02/prweb14062199.htm

Bioquark, Inc., (http://www.bioquark.com) a life sciences company focused on the development of novel biologics for complex regeneration and disease reversion, and SC21 Biotech, (http://www.sc21bio.tech), a biotechnology company focused on translational therapeutic applications of autologous stem cell therapy, have announced a collaboration to focus on novel cellular reprogramming and production approaches for CCR5 Delta32 homozygous cord blood stem cells, for long-term control of HIV via transplantation.

“We are very excited about this collaboration with SC21 Biotech,” said Ira S. Pastor, CEO, Bioquark Inc. “The natural synergy of our cellular reprogramming tools and SC21 Biotech’s translational cell therapy experience, will make for a transformational opportunity in this area of HIV disease control.”

HIV-1 infection afflicts more than 35 million people worldwide. For individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 infection. The only documented case for an HIV/AIDS cure was a patient with HIV-1 and acute myeloid leukemia who received allogeneic hematopoietic cell transplantation from a graft that carried the HIV-resistant CCR5-Delta32 homozygous mutation. The patient has remained without any evidence of HIV infection for more than 8 years after discontinuation of antiretroviral drug therapy.

However, identifying immune matched adult CCR5- Delta32 homozygous donors for a given patients is not readily feasible in part because the prevalence is in only about 0.8%–1% of individuals of northern European descent and much less in other ethnic groups, as well as the fact that for such transplants with adult cells there needs to be a very close HLA match between donor and patient.

In contrast, cord blood that is CCR5- Delta32 homozygous provides a major advantage in that much less stringent HLA matching is required between donor and patient. However, a technological method to cost effectively and industrially scale the production of such cells has been missing.

“We look forward to working closely with Bioquark Inc. on this exciting initiative,” said Mr. Paul Collier, Managing Director of SC21 Biotech. “The ability to apply Bioquark’s cellular reprogramming tools in order to produce industrial quantities of such precious cell lines will offer a much greater global penetration of this important therapeutic modality for HIV.”

“Bioquark has spent several years studying the evolutionarily perfected ability of bioactive moieties found in ooplasms to turn back biological time and re-set cellular regulatory state” said Dr. Sergei Paylian, Founder, CSO, and President, Bioquark Inc. “This unique initiative is one more step in our broad translation of such natural capabilities to control the progression of human diseases.”

About Bioquark, Inc.

Bioquark Inc. is focused on the development of natural biologic based products, services, and technologies, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing both biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.

About SC21 Biotech

SC21 Biotech is a novel a biotechnology company focused on translational therapeutic applications, as well as expedited, experimental access for “no option” patients, to a novel range of regenerative and reparative biomedical products and services, with the goal of reducing human degeneration, suffering, and death.

Congrats Dr. Happer.

I’ve been waiting to find out who will be Pres. Trump’s science adviser. It appears to be physicist Dr. William Happer, a physicist currently teaching at Princeont University, and former Director of the U.S. Department of Energy’s Office of Science from 1991–1993. He’s no slouch as a scientist. His work for the Air Force on the sodium guidestar laser platform for the military’s missile defense program provided information on the tropopause layer in the upper atmosphere, which is where atmospheric wave fronts distort both starlight and laser emissions, and where heat either begins to leak into space or does not, depending on how much and what kind of gas is blocking heat radiation.

The tropopause is the boundary between the troposphere, where we live and where weather takes place, and the stratosphere. The layers above that are the stratosphere, where stratocirrus clouds form as floating clouds of ice, the mesosphere, the thermosphere and the top, very thin layer, the exosphere. Beyond that is space.

Dr. Happer’s view of the whole climate thing clashes badly with the PC crowd’s notions about it, mostly because during the development of the sodium guidestar, he had to learn the physics and chemistry of the troposphere and the tropopause, and the layers above the troposphere.

Read more

“Launched in 2007, the Fuller Challenge has defined an emerging field of practice: the whole systems approach to understanding and intervening in complex and interrelated crises for wide-scale social and environmental impact. The entry criteria have established a new framework through which to identify and measure effective, enduring solutions to global sustainability’s most entrenched challenges. The rigorous selection process has set a unique standard, gaining renown as “Socially-Responsible Design’s Highest Award.”

The Fuller Challenge attracts bold, visionary, tangible initiatives focused on a well-defined need of critical importance. Winning solutions are regionally specific yet globally applicable and present a truly comprehensive, anticipatory, integrated approach to solving the world’s complex problems.”

Deadline is March 31, 2017

It looks like Self Driving cars may create a US organ shortage that finally acts as the Kick in the Ass to force stem cell generated organs on to the market. Enough of the ‘in the future’ we might have these Nonsesne.

Science, however, can offer better a better solution.

The waiting lists for donor organs are long — 120,000 people on a given day — and ever increasing. With fewer donor organs to go around, researchers are working on other ways to get people the parts they need. With help from 3D printing and other bioengineering technologies, we will eventually be able to grow our own organs and stop relying on donors.

Related: How Technology is Tackling Joe Biden’s Cancer Moonshot

“It’s like a race in which there’s multiple different players, but no matter which one of them winds up winning, it’s good,” says Ali Khademhosseini, a bioengineer at Harvard Medical School.

Read more

At school you may have been taught that helium was a noble gas because it was totally unreactive.

But, new research suggests it might not be as virtuous as we first thought.

An international team of scientists has created a stable helium compound which is composed of both helium and sodium atoms, and say their discovery marks a ‘new frontier of chemistry.’

Read more

By Jonathan Latham, PhD

Test your understanding of the living world with this simple question. What kind of biomolecule is found in all living organisms? If your answer is “DNA”, you are incorrect. The mistake is very forgiveable though. The standard English-language biology education casts DNA (DeoxyriboNucleic Acid) as the master molecule of life, coordinating and controlling most, if not all, living functions. This master molecule concept is popular. It is plausible. It is taught in every university and high school. But it is wrong. DNA is no master controller, nor is it even at the centre of biology. Instead, science overwhelmingly shows that life is self-organised and thus the pieces are in place for biology to undergo the ultimate paradigm shift.

Read more

Off to the races again; hope folks are onboard. Quantum Bio will grow in importance; and you were warned.

Microsoft today announced that they have open sourced Bio Model Analyzer, a cloud-based tool which allows for biologists to model cell interaction and communication. This latest move is one of the many Microsoft Research initiatives which aims to help lab experts use computer science to speed up breakthroughs in cancer research and treatment.

According to the post, the Bio Model Analzyer (BMA) allows for researchers and science to compare the normal processes of healthy cells to the abnormal processes that occur when disease infects the body. Set against more traditional methods, when using computers, researchers can quickly explore many more possibilities than were previously possible. Jasmin Fisher, a Senior researcher in the programming principles and tools group in Microsoft’s Cambridge, U.K explains in the post:

“That, in turn, can speed up research in areas like drug interaction and resistance, and it could eventually provide patients with more personalized and effective cancer treatments… We are trying to change the way research is done on a daily basis in biology.”

Read more

Back in September, the Chan Zuckerberg Initiative – the philanthropic company set up by Facebook CEO Mark Zuckerberg and his wife, Dr. Priscilla Chan – set a goal to invest $3 billion to cure, prevent, and manage disease by the end of the century.

The company has taken a huge first step toward the objective by partnering with scientists, doctors, engineers, and other key stakeholders. With the acquisition of Toronto-based company, Meta, the team is moving even closer to their goal by creating tools and technology designed to empower the scientific community.

Meta is a research paper search engine that uses artificial intelligence (AI) to deliver the most relevant results to researchers. Following this acquisition, the Chan Zuckerberg initiative will enhance the service before eventually rolling it out for free.

Read more