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Small, safer vessels could be ‘silicon chip’ that ushers in new nuclear age.

For airliners, cargo ships, nuclear power plants and other critical technologies, strength and durability are essential. This is why many contain a remarkably strong and corrosion-resistant alloy called 17–4 precipitation hardening (PH) stainless steel. Now, for the first time ever, 17–4 PH steel can be consistently 3D-printed while retaining its favorable characteristics.

A team of researchers.

Scientists managed to start the same chemical process that powers the Sun on August 8, 2021, by putting more electricity into a tiny gold capsule than the entire US electric system could handle.

It is extremely astonishing how the power of 192 laser beams sparked the same thermonuclear fire that fuels the Sun for a nanosecond.

The Sun produces energy by hurling hydrogen atoms together, generating helium in the process. We are now closer than ever to being able to harness chemical reactions with enough force to power the Sun. This is possible because fusion power technology has advanced.

The accident at reactor four of the Chernobyl Nuclear Power Plant in 1986 generated the largest release of radioactive material into the environment in human history. The impact of the acute exposure to high doses of radiation was severe for the environment and the human population. But more than three decades after the accident, Chernobyl has become one of the largest nature reserves in Europe. A diverse range of endangered species finds refuge there today, including bears, wolves, and lynxes.

Radiation can damage the genetic material of living organisms and generate undesirable mutations. However, one of the most interesting research topics in Chernobyl is trying to detect if some species are actually adapting to live with radiation. As with other pollutants, radiation could be a very strong selective factor, favoring organisms with mechanisms that increase their survival in areas contaminated with radioactive substances.

A new study by Zap Energy will assess the feasibility of siting a Zap fusion energy pilot plant at Washington’s only remaining coal power station.

Zap Energy will study the potential benefits of transitioning a natural gas power plant to a first-of-a-kind fusion pilot plant.

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The joint research team of Professor Choi Hongsoo at Robotics Engineering, DGIST, a senior researcher Jinyoung Kim from DGIST-ETH Microrobotics Research Center, and the research team of Professor Sung Won Kim at Seoul St. Mary’s Hospital of the Catholic University, made a breakthrough for the improvement of the therapeutic efficacy and safety in stem cell-based treatments.

The team developed a magnetically powered human nuclear transfer stem cells (hNTSC)-based microrobot and a method of minimally invasive delivery of therapeutic agents into the brain via the intranasal pathway. And they also accomplished transplanting the developed stem cell-based microrobot into brain tissue through the intranasal pathway that bypasses the blood-brain barrier. The proposed method is superior in efficacy and safety compared to the conventional surgical method and is expected to bring new possibilities of treating various intractable neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and brain tumors, in the future.

The limitation of stem cell therapy is the difficulty in delivering an exact amount of stem cells to an accurate targeted location deep in the body where the treatment is with high risk. Another limitation is that both efficacy and safety of the treatment are low owing to a large amount of the therapeutic agent loss during delivery, while the cost of the treatment is high. In particular, when delivering stem cells into the brain through blood, the efficiency of cell delivery may decrease owing to the “blood-brain barrier,” which is a unique and specific component of the cerebrovascular network.

Ideally, the nanopore dimensions should be comparable to those of the analyte for the presence of the analyte to produce a measurable change in the ionic current amplitude above the noise level. Nanopores can be formed in several ways, with a wide range of pore diameters. Biological nanopores are formed by the self-assembly of either protein subunits, peptides or even DNA scaffolds in lipid bilayers or block copolymer membranes^1,3,6,17,18. They possess atomically precise dimensions controlled by biopolymer sequences, providing the ability to recognize biomolecules with constriction diameters of ~1–10 nm. Solid-state nanopores are crafted in thin inorganic or plastic membranes (for example, SiN_x), which allows the nanopores to have extended diameters of up to hundreds of nanometres, permitting the entry or analysis of large biomolecules and complexes. The tools for fabricating solid-state nanopores, which include electron/ion milling^4,5, laser-based optical etching^19,20 and the dielectric breakdown of ultrathin solid membranes^21,22, can be used to manipulate nanopore size at the nanometre scale, but allow only limited control over the surface structure at the atomic level in contrast to biological nanopores. The chemical modification and genetic engineering of biological nanopores, or the introduction of biomolecules to functionalize solid-state nanopores²³, can further enhance the interactions between a nanopore and analytes, improving the overall sensitivity and selectivity of the device^{2,17,24,25,26}. This feature allows nanopores to controllably capture, identify and transport a wide variety of molecules and ions from bulk solution.

Nanopore technology was initially developed for the practicable stochastic sensing of ions and small molecules^2,27,28. Subsequently, many developmental efforts were focused on DNA sequencing^1,7,8,9. Now, however, nanopore applications extend well beyond sequencing, as the methodology has been adapted to analyse molecular heterogeneities and stochastic processes in many different biochemical systems (Fig. 1). First, a key advantage of nanopores lies in their ability to successively capture many single molecules one after the other at a relatively high rate, which allows nanopores to explore large populations of molecules at the single-molecule level in reasonable timeframes. Second, nanopores essentially convert the structural and chemical properties of the analytes into a measurable ionic current signal, even achieving enantiomer discrimination²⁹. The technology can be used to report on multiple molecular features while circumventing the need for labelling chemistries, which may complicate the overall analysis process and affect the molecular structures. For example, nanopores can discriminate nearly 13 different amino acids in a label-free manner, including some with minute structural differences³⁰. An important aspect is the ability of nanopores to identify species³¹ that lack suitable labels for signal amplification or whose information is hidden in the noise of analytical devices. Consequently, nanopores may serve well in molecular diagnostic applications required for precision medicine, which achieves the identification of nucleic acid, protein or metabolite analytes and other biomarkers^{11,32,33,34,35}. Third, nanopores provide a well-defined scaffold for controllably designing and constructing biomimetic systems, which involve a complex network of biomolecular interactions. These nanopore systems track the binding dynamics of transported biomolecules as they interact with nanopore surfaces, hence serving as a platform for unravelling complex biological processes (for example, the transport properties of nuclear pore complexes)^36,37,38,39. Fourth, chemical groups can be spatially aligned within a protein nanopore, providing a confined chemical environment for site-selective or regioselective covalent chemistry. This strategy has been used to engineer protein nanoreactors to monitor bond-breaking and bond-making events^40,41.

Here we discuss the latest advances in nanopore technologies beyond DNA sequencing and the future trajectory of the field, as well as the opportunities and main challenges for the next decade. We specifically address the emerging nanopore methods for protein analysis and protein sequencing, single-molecule covalent chemistry, single-molecule analysis of clinical samples and insights into the use of biomimetic pores for analysing complex biological processes.

Peng Xianjue unveils plans for combined fusion-fission reactor that could make China world’s first to achieve the elusive viable energy source.