Researchers have uncovered how the brain’s immune cells, called microglia, can act as protectors rather than destroyers in Alzheimer’s disease.
Category: neuroscience – Page 8
Micron-resolution fiber mapping in histology independent of sample preparation
To understand brain diseases, neuroscientists try to understand the intricate maze of nerve fibers in our brains. For analysis under a microscope, brain tissue is often immersed in paraffin wax to create high-quality slices. But until now, it has been impossible to precisely trace the densely packed nerves in these slices. Researchers from Delft, Stanford, Jülich, and Rotterdam have achieved a milestone: using the ComSLI technique, they can now map the fibers in any tissue sample with micrometer precision. The research is published in Nature Communications.
Micron-resolution fiber mapping in histology independent of sample preparation.
Georgiadis and colleagues conduct micron-resolution fibre mapping on multiple histological tissue sections. Their light-scattering technique works across different sample preparations and tissue types, including formalin-fixed paraffin-embedded brain sections.
Nanoparticle Treatment Reverses Alzheimer’s in Mice
Scientists have developed a nanoparticle-based treatment that successfully reversed Alzheimer’s disease in mice.
As detailed in a new paper published in the journal Signal Transduction and Targeted Therapy, the team co-led by the Institute for Bioengineering of Catalonia, Spain (IBEC), and West China Hospital, Sichuan University, developed bioactive “supramolecular drugs” that can proactively repair the blood-brain barrier.
The barrier plays an important role in the health of the brain, defending it from harmful substances and other pathogens. Alzheimer’s has been linked to a weakening of the barrier’s integrity, allowing for impairing toxins to make it through.
Decoding how cells choose to become muscles or neurons
Every cell in the body has the same DNA, but different cell types—such as muscle or brain cells—use different parts of it. Transcription factors help cells activate specific genes by reading certain DNA sequences, but since these sequences are common across the genome, scientists have long wondered how the factors know exactly where to bind.
Researchers in the Schübeler lab set out to address this question by looking at two closely related transcription factors—NGN2 and MyoD1—that steer cells toward becoming neurons and muscle cells, respectively. Using stem cells, they switched these transcription factors on one at a time and watched where they attached to the DNA and how they influenced gene expression. Their research is published in the journal Molecular Cell.
They found that the binding of transcription factors to the DNA molecule depends not only on the DNA sequence but also on how open the DNA is and which partner proteins are present. Sometimes, transcription factors act as “pioneer factors” and are able to open tightly packed DNA at specific sites to turn on genes. Small DNA changes—sometimes just one letter—and the proteins these factors partner with can affect whether genes are activated.
Breakthrough brain discovery reveals a natural way to relieve pain
Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, showing the brain’s built-in precision pain control system. The findings could lead to targeted, non-opioid treatments that use cannabinoid mechanisms instead of opioids, offering safer pain relief options.
Photoinduced non-reciprocal magnetism effectively violates Newton’s third law
A theoretical framework predicts the emergence of non-reciprocal interactions that effectively violate Newton’s third law in solids using light, report researchers from Japan. They demonstrate that by irradiating light of a carefully tuned frequency onto a magnetic metal, one can induce a torque that drives two magnetic layers into a spontaneous, persistent “chase-and-run” rotation. This work opens a new frontier in non-equilibrium materials science and suggests novel applications in light-controlled quantum materials.
In equilibrium, physical systems obey the law of action and reaction as per the free energy minimization principle. However, in non-equilibrium systems such as biological or active matter—interactions that effectively violate this law—the so-called non-reciprocal interactions are common.
For instance, the brain comprises inhibitory and excitatory neurons that interact non-reciprocally; the interaction between predator and prey is asymmetric, and colloids immersed in an optically active media demonstrate non-reciprocal interactions as well. A natural question arises: Can one implement such non-reciprocal interaction in solid-state electronic systems?
Hair-thin fiber can control thousands of brain neurons simultaneously
Fiber-optic technology revolutionized the telecommunications industry and may soon do the same for brain research.
A group of researchers from Washington University in St. Louis in both the McKelvey School of Engineering and WashU Medicine have created a new kind of fiber-optic device to manipulate neural activity deep in the brain. The device, called PRIME (Panoramically Reconfigurable IlluMinativE) fiber, delivers multi-site, reconfigurable optical stimulation through a single, hair-thin implant.
“By combining fiber-based techniques with optogenetics, we can achieve deep-brain stimulation at unprecedented scale,” said Song Hu, a professor of biomedical engineering at McKelvey Engineering, who collaborated with the laboratory of Adam Kepecs, a professor of neuroscience and of psychiatry at WashU Medicine.