Is a unique app designed to put you in the shoes of someone living with dementia. See one of the 360 clips from the experience.
http://awalkthroughdementia.org/
https://itunes.apple.com/us/app/a-walk-through-dementia/id1242267344
https://play.google.com/store/apps/details?id=com.alzheimers…a&hl=en_GB
A 21st Century Mystery School — “Creating New Paradigms In Wellness And Wisdom Never Seen Before, And Never More Needed Than Now” — Dr. Dennis McKenna, Founder, McKenna Academy of Natural Philosophy.
Dr. Dennis McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer, author, and Founder of the McKenna Academy of Natural Philosophy (www.mckenna.academy).
Dr. McKenna is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, a non-profit organization concerned with the investigation of the potential therapeutic uses of psychedelic medicines. He also serves on the Advisory Board of the American Botanical Council; as Founder and Executive Director for the Institute for Natural Products Research; as an Independent Research Consultant to the Phytomedicine and Nutraceutical Industry; was formerly on the Editorial Board of Phytomedicine, International Journal of Phytotherapy and Phytopharmacology; and is an adjunct professor in the Center for Spirituality and Healing at the University of Minnesota.
Dr. McKenna received his Master’s Degree in Botany from the University of Hawaii in 1,979 his Ph.D. in Botanical Sciences from the University of British Columbia in 1,984 and continued into post-doctoral research fellowships in the Laboratory of Clinical Pharmacology, National Institute of Mental Health (NIMH), and in the Department of Neurology, Stanford University School of Medicine.
Dr. McKenna’s research led to the development of natural products for the Aveda Corporation, as well as greater awareness of natural products and medicines. He has authored or co-authored over 50 peer-reviewed scientific papers and written multiple books, including “The Brotherhood of the Screaming Abyss: My Life with Terence McKenna”, co-author of “The Invisible Landscape” with his brother Terence, and co-author of a widely recognized reference work on herbal medicines, titled “Botanical Medicines: the Desk Reference for Major Herbal Supplements”.
The NIH-led Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative continues to teach us about the world’s most sophisticated computer: the human brain. This striking image offers a spectacular case in point, thanks to a new tool called Visual Neuronal Dynamics (VND).
VND is not a camera. It is a powerful software program that can display, animate, and analyze models of neurons and their connections, or networks, using 3D graphics. What you’re seeing in this colorful image is a strip of mouse primary visual cortex, the area in the brain where incoming sensory information gets processed into vision.
This strip contains more than 230,000 neurons of 17 different cell types. Long and spindly excitatory neurons that point upward (purple, blue, red, orange) are intermingled with short and stubby inhibitory neurons (green, cyan, magenta). Slicing through the neuronal landscape is a neuropixels probe (silver): a tiny flexible silicon detector that can record brain activity in awake animals [1].
Pear-shaped people, whose weight is generally distributed more evenly, rather than “apple shaped” individuals with fat clustered around their middle and often around internal organs like the liver in the abdominal cavity, are considered less at risk for cardiometabolic problems like heart disease and diabetes, as well as cognitive decline, says Stranahan, neuroscientist at the Medical College of Georgia at Augusta University.
Summary: Adipocytes, or beige fat cells, are indispensable to the anti-inflammatory and neuroprotective effects of subcutaneous fat, researchers say.
Source: Medical College of Georgia at Augusta University
Beige is considered a calming paint color, and scientists have new evidence that beige fat has a similar impact on the brain, bringing down the inflammation associated with the more common white fat and providing protection from dementia.
They have found that beige fat cells, which are typically intermingled with white fat cells in the subcutaneous fat present on “pear shaped” people, mediate subcutaneous fat’s brain protection, Dr. Alexis M. Stranahan and her colleagues report in the journal Nature Communications.
The ones Teresa is handling in this Cambridge laboratory are mini bile ducts, thin tubes that carry bile from the liver to the small intestine to help with digestion.
Teresa also has gut organoids in the incubator, while down the corridor a different team is developing brain organoids.
In fact, around the world, miniatures of everything from lungs to kidneys are being coaxed gently to life. And because they function just as organs do, they are perfect for research.
Summary: Brain connectivity at birth may impact emotional processing and social development later in childhood, especially in children born preterm. Researchers found children born preterm with a weaker uncinate fasciculus, the white-matter tract that connects brain regions associated with emotional processing, were more likely to interpret situations in a negative light.
Source: SfN
The strength of brain connections at birth may predict the future emotional and social development of babies born prematurely, according to new research published in eNeuro.
Evidence has been accumulating for almost a decade that the microbiome composition changes with age. In 2,012 research by my colleagues at University College Cork showed that diversity in the microbiome was linked to health outcomes in later life, including frailty.
In 1,895 on turning 50 Elie Metchnikoff became increasingly anxious about aging. As a result, the Russian Nobel prize-winning scientist, and one of the founders of immunology, turned his attention away from immunology and towards gerontology – a term that he coined.
He was fascinated by the role that intestinal bacteria play in health and disease and suggested that people from parts of eastern Europe lived longer because they ate a lot of fermented foods containing lactic acid bacteria.
Although popular at the time, this theory linking gut microbes to healthy aging was largely ignored by scientists until relatively recently. We now recognize the importance that the trillions of bacteria, known as the gut microbiome, have in regulating health and disease.
Since DNMT3A increases DNA methylation, the researchers used a natural product that donates methyl groups S-adenosylmethionine (SAMe) and to activate the retinoic acid receptor they treated the animals with vitamin A. They found that combined treatment with the methyl donor SAM and retinoic acid reversed PTSD-like behaviors.
Summary: Combining two natural products that modulate the epigenome, researchers believe they have identified a feasible approach to reversing symptoms of PTSD in animal models that could be effective in humans.
Source: Bar Ilan University
Exposure to a traumatic experience can lead to post-traumatic stress disorder (PTSD), an incapacitating disorder in susceptible persons with no reliable therapy. Particularly puzzling is understanding how transient exposure to trauma creates persistent long-term suffering from PTSD and why some people are susceptible to PTSD while others that were exposed to the same trauma remain resilient.
Epigenetic modifications are chemical marks on genes that program their activity. These marks are written into DNA during fetal development to correctly program how our genes function in different organs. However, research in the last two decades has suggested that these marks could also be modulated by experiences and exposures at different point of time in life.