Lifeboat Foundation

A pattern is emerging among COVID-19 patients arriving at hospitals in New York: Beyond fever, cough and shortness of breath, some are deeply disoriented to the point of not knowing where they are or what year it is.

At times this is linked to low oxygen levels in their blood, but in certain patients the confusion appears disproportionate to how their lungs are faring.

Jennifer Frontera, a neurologist at NYU Langone Brooklyn hospital seeing these patients, told AFP the findings were raising concerns about the impact of the coronavirus on the brain and nervous system.

American oncologists are rushing to prioritise the patients at greatest risk, institute new protections, and learn from their collective experiences, Bryn Nelson reports.

A patient in Washington, newly diagnosed with breast cancer, fought to get her lumpectomy surgery rescheduled after it was cancelled indefinitely. 1 A stuffy nose required another patient in Massachusetts with a recurrent brain tumour to undergo multiple layers of screening before he could receive his immunotherapy infusion. 2 A patient with bladder cancer in North Carolina couldn’t get immunotherapy at all because of a lack of surgical masks and gloves. 3 Then he was denied a surgical alternative because he needed a covid-19 test first. Since he hadn’t been admitted to a hospital with serious covid-19 symptoms, he didn’t meet the testing criteria.

Covid-19 has wreaked havoc on cancer care throughout the US as medical centres scramble to cancel or rearrange surgeries or treatments, tackle a continuing shortage of tests and supplies, and devise new safety protocols to protect a highly susceptible patient group.

Two new studies by researchers in Tel Aviv University and Harvard University on the subject were published in the journal Nature Biomedical Engineering on Monday.

Organs-on-a-chip were first developed in 2010 at Harvard University. Then, scientists took cells from a specific human organ — heart, brain, kidney and lung — and used tissue engineering techniques to put them in a plastic cartridge, or the so called chip. Despite the use of the term chip, which often refers to microchips, no computer parts are involved here.

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The lungs are ground zero for COVID-19, but blood clots may play a surprisingly big role in severe illness.

Brain cells, wrote the Spanish neuroanatomist Santiago Ramón y Cajal in the late 19^th century, “may die” and cannot “be regenerated.” Cajal then threw down the gauntlet, asserting that it was the job of the “science of the future to change, if possible, this harsh decree.” Jack Price’s engaging book The Future of Brain Repair details past, present, and future attempts to address Cajal’s formidable challenge. In so doing, it provides a vibrant and compelling guide to the important and rapidly evolving fields of stem cell–based therapies and brain repair, which together, he believes, are poised to deliver unprecedented changes to the management of brain diseases.

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“In corticospinal injuries using a mouse model, adult neurons begin a natural regeneration by revertiprocessng back to an embryonic state and that regeneration is sustained by a surprising gene.”

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When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the April 15, 2020 issue of Nature by researchers at University of California San Diego School of Medicine, with colleagues elsewhere. The scientists report that in their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function.

Continue reading “When Damaged, the Adult Brain Repairs Itself” »

Researchers all over the world are honing in on drugs that promote the regeneration of myelin — a substance in the brain critical for its normal function.

Of the spread of COVID-19 aboard the aircraft carrier USS Theodore Roosevelt and the subsequent relief of its Commanding Officer has highlighted the tension that exists between maintaining military readiness and the need to safeguard the health of members of the armed forces in the face of a pandemic.

The disease has been a feature of war for the vast majority of human history – from the plague that ravaged Athens early in the Peloponnesian War, killing the Athenian strategos Pericles; to the diseases that European settlers brought with them to the New World, devastating local populations; to the host of tropical diseases that caused appalling casualties in the China-Burma-India and Southwest Pacific theaters in World War II. The fact that we were surprised by the emergence, growth, and spread of COVID-19 reflects the false conceit of 21^st century life that we have “conquered” disease.

In fact, pandemics are but one class of low-probability but high-impact contingencies that we could face in the coming years, including an earthquake or other natural disaster in a major urban area, regime change in an important state, and the collapse of financial markets leading to a global depression. When I served as Deputy Assistant Secretary of Defense for Policy Planning between 2006 and 2009, we explored a series of such “shocks” as well as the role the Defense Department could play in responding to them as a way of helping the Department’s leaders address such contingencies. During my time in the Pentagon, we also held a series of wargames with members of Congress and their staff, governors of several states and their cabinets, and the government of Mexico, to explore in depth the consequences of a pandemic. Much of what we found then resonates with what we are experiencing now.

SAN DIEGO (CNS) – Injured adult brain cells revert to an embryonic state and become capable of re-growing new connections, which under the right conditions can help restore lost brain function, according to findings published Wednesday by researchers at UC San Diego School of Medicine.

The findings, published in the academic journal ‘Nature,’ were part of a collaborative study between UC San Diego, UCLA and the University of Tennessee.

Repairing damage to the brain and spinal cord, until relatively recently, seemed an impossible task. The new study lays out a “transcriptional roadmap of regeneration in the adult brain.”