Lifeboat Foundation

How can we promote the creation of new neurons — and why is it so important?

Resveratrol may reduce aging within the brain.

Deficits in the cerebral microcirculation contribute to age-related cognitive decline. In a pilot study of postmenopausal women, we found that supplementation with a low dose of resveratrol, a phytoestrogen, for 14 weeks improved cerebrovascular and cognitive functions. We have since undertaken a larger, longer term study to confirm these benefits. Postmenopausal women aged 45–85 years (n = 129) were randomized to take placebo or 75 mg trans-resveratrol twice daily for 12 months. Effects on cognition, cerebral blood flow, cerebrovascular responsiveness (CVR) and cardiometabolic markers (blood pressure, diabetes markers and fasting lipids) were assessed. Compared to placebo, resveratrol improved overall cognitive performance (P < 0.001) and attenuated the decline in CVR to cognitive stimuli (P = The latter effect was associated with reduction of fasting blood glucose (r = P = This long-term study confirms that regular consumption of resveratrol can enhance cognitive and cerebrovascular functions in postmenopausal women, with the potential to slow cognitive decline due to ageing and menopause. View Full-Text.

A brain–machine interface that enables multi-channel recordings of neural activity could improve human prosthetics and enhance understanding of the brain.

Presence and location of gray matter in the brain may indicate whether acupuncture is an effective method of treating migraine without aura, according to a study published in Frontiers in Neurology.

Presence and location of gray matter (GM) in the brain may indicate whether acupuncture is an effective method of treating migraine without aura (MwoA), according to a study published in Frontiers in Neurology.

In many countries acupuncture is used as a treatment for migraine, but there is insufficient evidence to claim it is effective for all migraineurs. According to researchers, “about 50% of patients do not achieve substantial improvement after acupuncture.” However, determining which patients may benefit from acupuncture will prevent nonresponders from undergoing time-consuming and unsuccessful treatment.

Massaging key parts of the brain with a pulsating magnetic field can do wonders for some living with chronic depression. For others, it falls well short of promising a life without a debilitating mood disorder.

The overwhelmingly positive results of an unblinded experiment on a small group of volunteers suggests some tweaks to the protocol might improve the odds of it working for people who have failed to find a solution elsewhere.

Researchers from Stanford and Palo Alto University in the US have shown in an open study on 21 people that administering five times the overall dosage of pulses across a higher number of daily sessions not only seems safe, but could achieve much better results.

An ongoing long-term trial suggests high levels of amyloid proteins in the brain do serve as an early sign of Alzheimer’s disease before cognitive decline becomes apparent.

A new study presenting the first data from a long-running US government trial is suggesting high levels of amyloid proteins in the brains of cognitively normal older adults can be an effective presymptomatic sign of early stage Alzheimer’s disease.

Over the last few decades, the amyloid hypothesis has guided the majority of research into an Alzheimer’s disease treatment. The idea is that a build up of toxic amyloid proteins in the brain, called plaques, is the primary degenerative driver behind the disease.

Continue reading “Alzheimer’s trial supports high amyloid levels as early sign of disease” »

Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats’ brains. The study has now been published in the research journal PNAS.

“Six months after the transplantation, we could see how the new cells had repaired the damage that a stroke had caused in the rats’ brains,” says Professor Zaal Kokaia, who together with senior professor Olle Lindvall and researcher Sara Palma-Tortosa at the Division of Neurology is behind the study.

Several previous studies from the Lund team and others have shown that it is possible to transplant nerve cells derived from human stem cells or from reprogrammed cells into brains of rats afflicted by stroke. However, it was not known whether the transplanted cells can form connections correctly in the rat brain in a way that restores normal movement and feeling.

A new form of magnetic brain stimulation rapidly relieved symptoms of severe depression in 90% of participants in a small study conducted by researchers at the Stanford University School of Medicine.

The researchers are conducting a larger, double-blinded trial in which half the participants are receiving fake treatment. The researchers are optimistic the second trial will prove to be similarly effective in treating people whose condition hasn’t improved with medication, talk therapy or other forms of electromagnetic stimulation.

The treatment is called Stanford Accelerated Intelligent Neuromodulation Therapy, or SAINT. It is a form of transcranial magnetic stimulation, which is approved by the Food and Drug Administration for treatment of depression. The researchers reported that the therapy improves on current FDA-approved protocols by increasing the number of magnetic pulses, speeding up the pace of the treatment and targeting the pulses according to each individual’s neurocircuitry.

The brain is steadily engaged in thought. These internal communications are also usually bombarded with external sensory events. Hence, the impact of the two neuronal processes need to be permanently fine-tuned to avoid their imbalance. A team of scientists at the Ruhr-Universität Bochum (RUB) has now revealed the role of the neurotransmitter serotonin in this mechanism. They discovered that distinct serotonergic receptor types control the gain of both streams of information in a separable manner. Their findings may facilitate new concepts of diagnosis and therapies for neuronal disorders related to malfunction of the serotonin system. The study is published online in the open access journal eLife on 7 April 2020.

Impacting on different streams of information in the brain

Dr. Dirk Jancke, head of the Optical Imaging Group at the Institute of Neural Computation, says, “Imagine sitting with your family at dinner, and a heated debate is going on about how to properly organize some internal affairs. Suddenly, the phone starts ringing; you are picking up while family discussion goes on. In order to understand the calling party correctly, the crowd in the back must speak lower or the caller needs to speak up. Thus, the loudness of each internal background conversation and external call need to be properly adjusted to ensure non-interfered, separable information transfer.” As in this anecdote, comparable brain processes involve serotonin.