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Digital immortality: would you upload your mind to a computer?

But what would it actually mean to transfer your mind from “meat space” to cyberspace, and how could it be done? The basic idea rests on several assumptions, says Angela Thornton, a researcher at the Horizon Centre for Doctoral Training at University of Nottingham, who is also partnered with the Carboncopies Foundation, a non-profit that focuses on “whole brain emulation” and the creation of substrate-independent minds. “It assumes that we could replicate our brain [with] a certain level of understanding of how it works,” she says. “Not necessarily knowing all the detail, but enough to be able to emulate it.” Then, she adds, we have to make the assumption that the “mind” (i.e. the abstract part of us that thinks, remembers, imagines and senses) naturally emerges from the structures of the physical brain.

This is a lot to take on, which is partly why current brain emulation research is still stuck at the level of worms and, in more advanced studies, mice. Whether you agree with them or not, though, the arguments to take experiments further – toward larger mammals and, finally, humans – are quite obvious. For one, we could theoretically ‘live’ forever as a disembodied consciousness (or at least until the machines that hosted our virtual minds were destroyed), and continue interacting with our loved ones after they’ve passed as well. It’s possible that this could also go some way to solving the alleged population crisis, while limiting the impact of our physical bodies on the planet’s finite resources.

Of course, there are plenty of important questions that need answers before any of this can actually happen. Below, Thornton helps us unpick some of the main constraints and controversies.

Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics

Optogenetics has revolutionized neuroscience understanding by allowing spatiotemporal control over cell-type specific neurons in neural circuits. However, the sluggish development of noninvasive photon delivery in the brain has limited the clinical application of optogenetics. Focused ultrasound (FUS)-derived mechanoluminescence has emerged as a promising tool for in situ photon emission, but there is not yet a biocompatible liquid-phase mechanoluminescence system for spatiotemporal optogenetics. To achieve noninvasive optogenetics with a high temporal resolution and desirable biocompatibility, we have developed liposome (Lipo@IR780/L012) nanoparticles for FUS-triggered mechanoluminescence in brain photon delivery. Synchronized and stable blue light emission was generated in solution under FUS irradiation due to the cascade reactions in liposomes.

Research explores cell-based theory of consciousness and what it entails

Humans and other animals with brains perhaps aren’t the only beings on the planet to experience consciousness, says a study in the journal EMBO Reports.

Consciousness instead underpins all life forms, from the smallest cells to the most complex organisms. Far from being limited to creatures like ourselves, the cell-based of consciousness frames the phenomenon a fundamental part of life itself.

Conventional thinking about consciousness—called the standard model of consciousness—focuses on the brain, supposing only complex organisms like humans and animals have it. But the new cell-based theory argues that consciousness started with the very first cells that emerged about 3.8 billion years ago and plants, bacteria and even amoebas have it.

New treatment reverses Alzheimer’s disease signs, improves memory function in preclinical study

A “chaperone” molecule that slows the formation of certain proteins reversed disease signs, including memory impairment, in a mouse model of Alzheimer’s disease, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

In the study, published in Aging Biology, researchers examined the effects of a compound called 4-phenylbutyrate (PBA), a fatty-acid molecule known to work as a “chemical chaperone” that inhibits . In mice that model Alzheimer’s disease, injections of PBA helped to restore signs of normal proteostasis (the protein regulation process) in the animals’ brains while also dramatically improving their performance on a standard memory test, even when administered late in the disease course.

“By generally improving neuronal and cellular health, we can mitigate or delay ,” said study senior author Nirinjini Naidoo, Ph.D., a research associate professor of Sleep Medicine. “In addition, reducing proteotoxicity— to the cell that is caused by an accumulation of impaired and misfolded proteins—can help improve some previously lost brain functions.”

Answering a 40-Year-Old Question — Scientists Reveal Structures of Neurotransmitter Transporter

Neurons communicate through chemical signals known as neurotransmitters. Researchers at St. Jude Children’s Research Hospital, leveraging their expertise in structural biology, have successfully elucidated the structures of the vesicular monoamine transporter 2 (VMAT2), a key component of neuronal communication.

By visualizing VMAT2 in different states, scientists now better understand how it functions and how the different shapes the protein takes influence drug binding — critical information for drug development to treat hyperkinetic (excess movement) disorders such as Tourette syndrome. The work was recently published in the journal Nature.

Depression Linked to 20% Lower Taurine Levels in Hippocampus

Precise observation using ultra-high magnetic field 7T MRI.

For the first time, a research team in Korea has discovered there is a significant relationship between depression and the taurine concentration in the hippocampus, an area of the brain responsible for memory and learning functions. This discovery provides the opportunity to publicize the role and importance of taurine in future prevention, diagnosis, and treatment of depression.

Advanced imaging techniques reveal key insights.

Scientists discover a framework in the brain for organizing the order of things

“I believe we have found one of the brain’s prototypes for building sequences” says Professor Edvard Moser.


Scientists at NTNU’s Kavli Institute for Systems Neuroscience in Norway have discovered a pattern of activity in the brain that serves as a template for building sequential experiences.

“I believe we have found one of the brain’s prototypes for building sequences,” says Professor Edvard Moser. He describes the activity pattern as “a fundamental algorithm that is intrinsic to the brain and independent of experience.”

The breakthrough discovery was published in Nature.

A New Brain-Like Supercomputer Aims to Match the Scale of the Human Brain

A supercomputer scheduled to go online in April 2024 will rival the estimated rate of operations in the human brain, according to researchers in Australia. The machine, called DeepSouth, is capable of performing 228 trillion operations per second.

It’s the world’s first supercomputer capable of simulating networks of neurons and synapses (key biological structures that make up our nervous system) at the scale of the human brain.

DeepSouth belongs to an approach known as neuromorphic computing, which aims to mimic the biological processes of the human brain. It will be run from the International Center for Neuromorphic Systems at Western Sydney University.

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