Lifeboat Foundation

Children with hereditary deafness regained their hearing thanks to a type of gene therapy, a new study published on Wednesday found.

In a clinical trial, co-led by investigators from Mass Eye and Ear, a specialty hospital in Boston, six children who had a form of genetic deafness called DFNB9 were examined.

This deafness is caused by mutations of the OTOF gene. This mutation fails to produce a protein known as otoferlin, which is necessary for the transmission of sound signals from the ear to the brain, according to the researchers.

A recent study from Stanford’s Wu Tsai Neurosciences Institute has shed light on the interplay between two key brain chemicals, dopamine and serotonin, revealing their opposing roles in shaping our decisions and learning processes. Published in Nature, the research demonstrates for the first time that dopamine and serotonin operate as a “gas and brake” system, jointly influencing how we learn from rewards. The findings have broad implications, from understanding everyday decision-making to developing treatments for neurological and psychiatric conditions such as addiction, depression, and Parkinson’s disease.

Dopamine and serotonin are crucial to many aspects of human behavior, including reward processing and decision-making. Both neurotransmitters are also implicated in a variety of mental health disorders. While previous research has established their individual roles—dopamine is linked to reward prediction and seeking, while serotonin promotes long-term thinking and patience—the precise nature of their interaction has remained unclear.

Two competing theories have sought to explain their dynamic: the “synergy hypothesis,” which posits that dopamine focuses on immediate rewards and serotonin on long-term benefits, and the “opponency hypothesis,” suggesting the two act in opposition, with dopamine encouraging impulsive action and serotonin promoting restraint. The Stanford researchers aimed to directly test these theories using advanced experimental methods.

MIT physicists and colleagues have for the first time measured the geometry, or shape, of electrons in solids at the quantum level. Scientists have long known how to measure the energies and velocities of electrons in crystalline materials, but until now, those systems’ quantum geometry could only be inferred theoretically, or sometimes not at all.

The work, reported in the November 25 issue of Nature Physics, “opens new avenues for understanding and manipulating the quantum properties of materials,” says Riccardo Comin, MIT’s Class of 1947 Career Development Associate Professor of Physics and leader of the work.

“We’ve essentially developed a blueprint for obtaining some completely new information that couldn’t be obtained before,” says Comin, who is also affiliated with MIT’s Materials Research Laboratory and the Research Laboratory of Electronics.

Cancer immunotherapy strategy equips T cells with molecular GPS that lets them home in on brain tumors and sites of neuroinflammation.

Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.

In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino acids — can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.

This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.

Scientists achieve two-way communication in lucid dreams, unlocking new possibilities in therapy and skill learning.

The Digital Brain platform is capable of simulating spiking neuronal networks at the neuronal scale of the human brain. The platform is used to reproduce blood-oxygen-level-dependent signals in both the resting state and action, thereby predicting the visual evaluation scores.

Research published in Nature has revealed that neural computations in different individuals can be implemented to solve the same decision-making tasks, even when the behavioral outcomes appear identical.

Cognitive flexibility is the ability of a brain to adapt its response to the same external stimulus, like light or sound, based on different contexts. For example, if someone calls your name in a crowded room, you must focus on the sound’s location or the voice characteristics to identify the person. This flexibility in selecting and processing relevant information while ignoring irrelevant information is crucial for survival and effective interaction with our environment.

While previously studied, the individual variability in neural computations yielding the same outcomes is poorly understood and lacks a comprehensive framework. The researchers in the Nature study aimed to understand these mechanisms.

Slow-wave sleep plays a crucial role in strengthening memory by enhancing synaptic connections in the brain, with new findings suggesting potential methods for boosting memory through targeted stimulation.

For nearly two decades, scientists have known that slow, synchronized electrical waves in the brain during deep sleep play a key role in forming memories. However, the underlying reason remained unclear — until now. In a new study published in Nature Communications, researchers from Charité – Universitätsmedizin Berlin propose an explanation. They found that these slow waves make the neocortex, the brain’s long-term memory center, especially receptive to new information. This discovery could pave the way for more effective memory-enhancing treatments in the future.

How Memories Form During Sleep