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Category: neuroscience – Page 247

Why Is Anything Conscious?

We tackle the hard problem of consciousness taking the naturally-selected, self-organising, embodied organism as our starting point. We provide a mathematical formalism describing how biological systems self-organise to hierarchically interpret unlabelled sensory information according to valence and specific needs. Such interpretations imply behavioural policies which can only be differentiated from each other by the qualitative aspect of information processing. Selection pressures favour systems that can intervene in the world to achieve homeostatic and reproductive goals. Quality is a property arising in such systems to link cause to affect to motivate real world interventions. This produces a range of qualitative classifiers (interoceptive and exteroceptive) that motivate specific actions and determine priorities and preferences.

Targeting Glucose May Spark Neurogenesis

Summary: Neural stem cells, which create new neurons in the brain, become less active with age due to elevated glucose levels. Researchers found that by knocking out the glucose transporter gene GLUT4 in older mice, they could significantly increase the production of new neurons.

This discovery opens up potential pathways for both genetic and behavioral interventions to stimulate brain repair, including the possibility of a low-carbohydrate diet. The findings could help treat neurodegenerative diseases and aid in brain recovery after injury.

Brain scan study shows what happens in the brain when a person with schizophrenia hears voices

Patients with certain mental disorders, including schizophrenia, often hear voices in the absence of sound.

Auditory hallucinations are likely the result of abnormalities in two brain processes: a broken corollary discharge that fails to suppress self-generated sounds, and a noisy efference copy that makes the brain hear these sounds more intensely than it should. That is the conclusion of a study published October 3 in the open-access journal PLOS Biology by Xing Tian, of New York University Shanghai, China, and colleagues.

In the new study, researchers carried out electroencephalogram (EEG) experiments measuring the brain waves of 20 patients diagnosed with schizophrenia with and 20 patients diagnosed with who had never experienced such hallucinations.

The Z-Bell℠ Test: A Breakthrough in Eye-Ear Testing

🧠 Neuromodulation through the eyes 👀

Neuroplasticity, also known as neural plasticity or brain plasticity, is a process that involves adaptive structural and functional changes to the brain.

Founded and directed by Deborah Zelinsky, O.D., F.N.O.R.A., F.C.O.V.D.

Just as with eye-hand coordination, integration of vision and sound – eye-ear connection – must be developed. If the two senses are out of sync, a person can experience difficulties in academics, social situations and activities such as sports.

Balance between vision and hearing is necessary for a person to learn letter sounds, for example, while applying those sounds to the words they see on a page. In social situations, a person can better understand what another is saying – and meaning — by watching body language and facial expression. Autistic patients cannot discern the nuances of a joke because they simply listen. They do not connect sound and vision, because the environment around them is too confusing.

A student whose eyesight is more sensitive than his or her hearing may be easily distracted by activities and moving objects in the environment and unable to concentrate on what the teacher is saying. People whose peripheral vision is not sufficiently “tuned in” may have to turn their head before finding what is causing a certain sound.

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Tracking neurons across days with high-density probes

https://rdcu.be/dVhCN

Imagine trying to understand the brain’s activity over time—an incredibly complex and dynamic process that happens at different speeds.

To solve this problem, we developed a pipeline called UnitMatch, which operates after spike sorting. Before applying UnitMatch, the user spike sorts each recording independently using their preferred algorithm. UnitMatch then deploys a naive Bayes classifier on the units’ average waveform in each recording and tracks units across recordings, assigning a probability to each match.

We tested UnitMatch on sequences of Neuropixels recordings from multiple regions of the mouse brain and found that it reliably tracked neurons across weeks. Its performance compares well to the concatenated method and to curation by human experts, while being much faster and applicable to longer sequences of recordings.

Because UnitMatch relies only on each unit’s spike waveform, and not on any functional properties, it can be used to test whether these properties change over time. Indeed, while units can maintain firing properties such as inter-spike interval (ISI) distribution10,11,12,19,20,28,29 and sensory, cognitive or motor correlates11,13,14,15,24,28,29,31,38, the stability of these properties cannot be assumed. In fact, it is often the question being investigated6,7,19,21,22,23,25,27,28,38,39,40.

Synchron Brain Implant Achieves New Milestone in Controlling Amazon, Apple Technology

With this success, Synchon is looking to take its experiments to the next level by adding more participants in a larger study. CEO Tom Oxley claims that their future study would focus more on ‘gathering brain data to improve the BCI.

Are Brain-Computer Interfaces the Future of Technology?

Different companies have already begun their developments and clinical trials of their brain-computer interfaces (BCIs) which need to be implanted on human test subjects, centering mostly on paraplegic patients. One of the most famous companies behind this is Elon Musk’s Neuralink, and their first patient, Noland Arbaugh, testified how the implant can help in controlling technology, and in his case, gaming.

139,000 Neurons of Adult Fruit Fly Brain Mapped For The First Time

Unlocking the complexities of the fruit fly brain is a crucial step toward understanding the human brain. Fruit flies share many genetic similarities with humans, making them a valuable model organism for studying brain functions as well as diseases.

“An estimated 75% of human genes related to diseases have homologs in the fly genome,” Sebastian Seung, co-leader of the research team, told Interesting Engineering (IE).

“We’ve long known about the molecular similarities between fly and human brains. We have been slower to realize that there are also similarities at the circuit level, revealed by examining patterns of connectivity. We now know that fly circuits for olfaction, vision, and navigation have architectural similarities with mammalian circuits for the same functions,” Seung added.

250,000 DNA sequences successfully store 11.28 MB of MRI information

The team says that DNA — known for its stability and density — could be an ideal candidate for MRI data storage.

Brain MRI scans provide invaluable insights into our bodies.

Interestingly, the team successfully encoded 11.28 megabytes of brain MRI data into roughly 250,000 DNA sequences. This translates to a data density of 2.39 bits per base.

The encoded oligos, which are the DNA sequences containing the MRI data, are stored in a “dry powder form.” The oligos weigh only 3 micrograms, which is incredibly small. This suggests that a vast amount of data can be stored in a tiny space.

It can “support over 300 reads under current technical standards.”

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