🧠 🔬 💡
Study reveals shared brain proteomic signatures in Alzheimer’s disease and epilepsy, suggesting common molecular mechanisms that could pave the way for unified therapeutic strategies.
Drugs known as antidepressants target the serotonin transporter in nerve cells and are among the most commonly prescribed medicines worldwide, but are sometimes associated with significant side effects. As part of a study, a research group led by Thomas Stockner from MedUni Vienna identified the basic principles of serotonin transport and thus created a possible basis for the development of novel drugs with improved selectivity and with fewer undesirable effects. The results were recently published in the renowned scientific journal “Nature Communications”
While the desired effects of drugs unfold through the interaction with the relevant target structures, the undesirable side effects are often due to a lack of selectivity and therefore due to interactions with other target structures. Accordingly, developing drugs that can differentiate between the various physiologically relevant targets (e.g. transporters and receptors) is one of the challenges for research. A team led by Ralph Gradisch under the supervision of Thomas Stockner from MedUni Vienna’s Center for Physiology and Pharmacology set out to find a way to increase selectivity for the serotonin transporter while reducing interaction with other targets at nerve cells in the brain.
Multiple sclerosis (MS) is a neurological disease that usually leads to permanent disabilities. It affects about 2.9 million people worldwide, and about 15,000 in Switzerland alone. One key feature of the disease is that it causes the patient’s own immune system to attack and destroy the myelin sheaths in the central nervous system.
These protective sheaths insulate the nerve fibers, much like the plastic coating around a copper wire. Myelin sheaths ensure that electrical impulses travel quickly and efficiently from nerve cell to nerve cell. If they are damaged or become thinner, this can lead to irreversible visual, speech and coordination disorders.
So far, however, it hasn’t been possible to visualize the myelin sheaths well enough to reliably diagnose and treat MS. Now researchers at ETH Zurich, led by Markus Weiger and Emily Baadsvik from the Institute for Biomedical Engineering, have developed a new magnetic resonance imaging (MRI) procedure that maps the condition of the myelin sheaths more accurately than was previously possible. The researchers successfully tested the procedure on healthy people for the first time.
Elon Musk said Neuralink’s first patient was recovering well after being implanted with a product called Telepathy.
Ball is not alone in calling for a drastic rethink of how scientists discuss biology. There has been a flurry of publications in this vein in the past year, written by me and others2–4. All outline reasons to redefine what genes do. All highlight the physiological processes by which organisms control their genomes. And all argue that agency and purpose are definitive characteristics of life that have been overlooked in conventional, gene-centric views of biology.
This burst of activity represents a frustrated thought that “it is time to become impatient with the old view”, as Ball says. Genetics alone cannot help us to understand and treat many of the diseases that cause the biggest health-care burdens, such as schizophrenia, cardiovascular diseases and cancer. These conditions are physiological at their core, the author points out — despite having genetic components, they are nonetheless caused by cellular processes going awry. Those holistic processes are what we must understand, if we are to find cures.
Ultimately, Ball concludes that “we are at the beginning of a profound rethinking of how life works”. In my view, beginning is the key word here. Scientists must take care not to substitute an old set of dogmas with a new one. It’s time to stop pretending that, give or take a few bits and pieces, we know how life works. Instead, we must let our ideas evolve as more discoveries are made in the coming decades. Sitting in uncertainty, while working to make those discoveries, will be biology’s great task for the twenty-first century.
Recent neuroscience reveals insights into the gut-brain link, vision, addiction relapse, memory, autism, infant cognition, and moral judgments. The findings offer new treatment avenues and highlight the brain’s complex functions.
Scientists have made progress in understanding how the brain processes time, potentially rewriting the narrative on neural flexibility and cognitive function.
The research, led by Professor Arkarup Banerjee in the Cold Spring Harbor Laboratory, focused on the vocalizations of Alston’s singing mouse from Costa Rica, offers profound insights into how our brains may bend the perception of time to adapt to varying circumstances.
This phenomenon could have far-reaching implications across numerous fields including technology, education, and therapy.
A team of researchers has created the first functional 3D-printed brain tissue to examine the brain’s function and study various neurological disorders.
The first functional 3D-printed brain tissue has been developed to examine the human brain’s function and study various neurological disorders.
According to experts at the University of Wisconsin-Madison, printed tissue can “grow and function like typical brain tissue.”
Continue reading “First functional human brain tissue produced through 3D printing” »
As Neuralink makes strides, China’s MIIT unveils a tech roadmap, aiming to be the leader in brain-computer interfaces by 2027.
Tech billionaire Elon Musk says his Neuralink company has successfully implanted one of its wireless brain chips in a human for the first time.
