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Category: nanotechnology – Page 66

The delivery of drugs to specific target tissues and cells in the brain poses a significant challenge in brain therapeutics, primarily due to limited understanding of how nanoparticle (NP) properties influence drug biodistribution and off-target organ accumulation. This study addresses the limitations of previous research by using various predictive models based on collection of large data sets of 403 data points incorporating both numerical and categorical features. Machine learning techniques and comprehensive literature data analysis were used to develop models for predicting NP delivery to the brain. Furthermore, the physicochemical properties of loaded drugs and NPs were analyzed through a systematic analysis of pharmacodynamic parameters such as plasma area under the curve. The analysis employed various linear models, with a particular emphasis on linear mixed-effect models (LMEMs) that demonstrated exceptional accuracy. The model was validated via the preparation and administration of two distinct NP formulations via the intranasal and intravenous routes. Among the various modeling approaches, LMEMs exhibited superior performance in capturing underlying patterns. Factors such as the release rate and molecular weight had a negative impact on brain targeting. The model also suggests a slightly positive impact on brain targeting when the drug is a P-glycoprotein substrate.

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Optogenetics has revolutionized neuroscience understanding by allowing spatiotemporal control over cell-type specific neurons in neural circuits. However, the sluggish development of noninvasive photon delivery in the brain has limited the clinical application of optogenetics. Focused ultrasound (FUS)-derived mechanoluminescence has emerged as a promising tool for in situ photon emission, but there is not yet a biocompatible liquid-phase mechanoluminescence system for spatiotemporal optogenetics. To achieve noninvasive optogenetics with a high temporal resolution and desirable biocompatibility, we have developed liposome (Lipo@IR780/L012) nanoparticles for FUS-triggered mechanoluminescence in brain photon delivery. Synchronized and stable blue light emission was generated in solution under FUS irradiation due to the cascade reactions in liposomes.

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Researchers at the University of Sussex have discovered the transformative potential of Martian nanomaterials, potentially opening the door to sustainable habitation on the red planet.

Using resources and techniques currently applied on the International Space Station and by NASA, Dr. Conor Boland, a Lecturer in Materials Physics at the University of Sussex, led a research group that investigated the potential of nanomaterials—incredibly tiny components thousands of times smaller than a —for clean energy production and on Mars.

Taking what was considered a by NASA and applying only sustainable production methods, including water-based chemistry and low-energy processes, the researchers have successfully identified within gypsum nanomaterials—opening the door to potential clean energy and sustainable technology production on Mars.

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On the pursuit for anyons (Majoranas) in the context of the latest progress on multiple platforms.

Already, the graphene efforts have offered “a breath of fresh air” to the community, Alicea says. “It’s one of the most promising avenues that I’ve seen in a while.” Since leaving Microsoft, Zaletel has shifted his focus to graphene. “It’s clear that this is just where you should do it now,” he says.

But not everyone believes they will have enough control over the free-moving quasiparticles in the graphene system to scale up to an array of qubits—or that they can create big enough gaps to keep out intruders. Manipulating the quarter-charge quasiparticles in graphene is much more complicated than moving the Majoranas at the ends of nanowires, Kouwenhoven says. “It’s super interesting for physics, but for a quantum computer I don’t see it.”

Just across the parking lot from Station Q’s new office, a third kind of Majorana hunt is underway. In an unassuming black building branded Google AI Quantum, past the company rock-climbing wall and surfboard rack, a dozen or so proto–quantum computers dangle from workstations, hidden inside their chandelier-like cooling systems. Their chips contain arrays of dozens of qubits based on a more conventional technology: tiny loops of superconducting wires through which current oscillates between two electrical states. These qubits, like other standard approaches, are beset with errors, but Google researchers are hoping they can marry the Majorana’s innate error protection to their quantum chip.

Continue reading “A ghostly quasiparticle rooted in a century-old Italian mystery could unlock quantum computing’s potential” | >

Researchers in China have produced a phenomenon known as the giant skyrmion topological Hall effect in a two-dimensional material using only a small amount of current to manipulate the skyrmions responsible for it. The finding, which a team at Huazhong University of Science and Technology in Hubei observed in a ferromagnetic crystal discovered in 2022, comes about thanks to an electronic spin interaction known to stabilize skyrmions. Since the effect was apparent at a wide range of temperatures, including room temperature, it could prove useful for developing two-dimensional topological and spintronic devices such as racetrack memory, logic gates and spin nano-oscillators.

Skyrmions are quasiparticles with a vortex-like structure, and they exist in many materials, notably magnetic thin films and multilayers. They are robust to external perturbations, and at just tens of nanometres across, they are much smaller than the magnetic domains used to encode data in today’s hard disks. That makes them ideal building blocks for future data storage technologies such as “racetrack” memories.

Skyrmions can generally be identified in a material by spotting unusual features (for example, abnormal resistivity) in the Hall effect, which occurs when electrons flow through a conductor in the presence of an applied magnetic field. The magnetic field exerts a sideways force on the electrons, leading to a voltage difference in the conductor that is proportional to the strength of the field. If the conductor has an internal magnetic field or magnetic spin texture, like a skyrmion does, this also affects the electrons. In these circumstances, the Hall effect is known as the skyrmion topological Hall effect (THE).

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Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged immune system response that enhances the body’s ability to fight cancer but also make vaccines more effective in targeting tumors.

“This research marks a pivotal turning point in our understanding of how can be harnessed to optimize anticancer immunity,” said Hai-Quan Mao, director of Johns Hopkins’ Institute for NanoBioTechnology and professor in the Whiting School of Engineering’s Department of Materials Science and Engineering. “Our findings unlock new avenues for enhancing the efficacy of RNA-based treatments for and infectious diseases.”

The team’s results appear in Nature Biomedical Engineering.

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A nitrogen-vacancy (NV) center is a defect in the crystal structure of diamond, where a nitrogen atom replaces a carbon atom in the diamond lattice and a neighboring site in the lattice is vacant. This and other fluorescent defects in diamond, known as color centers, have attracted researchers’ attention owing to their quantum properties, such as single-photon emission at room temperature and with long coherence time. Their many applications include quantum information encoding and processing, and cell marking in biological studies.

Microfabrication in diamond is technically difficult, and nanodiamonds with color centers have been embedded in custom-designed structures as a way of integrating these quantum emitters into photonic devices. A study conducted at the University of São Paulo’s São Carlos Institute of Physics (IFSC-USP) in Brazil has established a method for this, as described in an article published in the journal Nanomaterials.

“We demonstrated a method of embedding fluorescent nanodiamonds in designed for this purpose, using two-photon polymerization [2PP],” Cleber Mendonça, a professor at IFSC-USP and last author of the article, told Agência FAPESP. “We studied the ideal concentration of nanodiamond in the photoresist to achieve structures with at least one fluorescent NV center and good structural and optical quality.” The photoresist is a light-sensitive material used in the fabrication process to transfer nanoscale patterns to the substrate.

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Detection efficiency is 1,000 times higher than conventional ion detectors due to high sensitivity.

An international research team led by quantum physicist Markus Arndt (University of Vienna) has achieved a breakthrough in the detection of protein ions: Due to their high energy sensitivity, superconducting nanowire detectors achieve almost 100% quantum efficiency and exceed the detection efficiency of conventional ion detectors at low energies by a factor of up to a 1,000. In contrast to conventional detectors, they can also distinguish macromolecules by their impact energy. This allows for more sensitive detection of proteins and it provides additional information in mass spectrometry. The results of this study were recently published in the journal Science Advances.

Advancements in Mass Spectrometry.

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A groundbreaking study introduces advanced nanometric optomechanical cavities, paving the way for more efficient quantum networks and improving quantum computing and communication technologies.

The ability to transmit information coherently in the band of the electromagnetic spectrum from microwave to infrared is vitally important to the development of the advanced quantum networks used in computing and communications.

A study conducted by researchers at the State University of Campinas (UNICAMP) in Brazil, in collaboration with colleagues at ETH Zurich in Switzerland and TU Delft in the Netherlands, focused on the use of nanometric optomechanical cavities for this purpose. These nanoscale resonators promote interaction between high-frequency mechanical vibrations and infrared light at wavelengths used by the telecommunications industry.

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By Chuck Brooks

Realizing the potential of Smart Cities will require public-private cooperation and security by design.

The idea of smart cities is starting to take shape as the digital era develops. A city that has developed a public-private infrastructure to support waste management, energy, transportation, water resources, smart building technology, sustainability, security operations and citizen services is referred to as a “smart city”. Realizing the potential of Smart Cities will require public-private cooperation and security by design.

A smart city functions as an applied innovation lab. Automation, robotics, enabling nanotechnologies, artificial intelligence (human/computer interface), printed electronics and photovoltaics, wearables (flexible electronics), and information technologies like real-time and predictive analytics, super-computing, 5G wireless networks, secure cloud computing, mobile devices, and virtualization are a few of the fascinating technological trends of the digital era that are influencing the development of smart cities.

Continue reading “The Emergence Of Smart Cities In The Digital Era” | >