Lifeboat Foundation

Investigating how proteins interact is key to understanding how cells work and communicate. In a new study published in Nature Communications, FMI researchers have provided key insights into how protein interactions are governed and how mutations influence cellular functions.

Proteins are the molecular machines of life, performing tasks ranging from driving chemical reactions to orchestrating cell communication. For these tasks, proteins must bind to the right partners with precision, avoiding mispairings that could disrupt cellular processes and lead to disease.

Scientists have long been curious about how changes in the sequence of amino acids —the building blocks of proteins—can alter a protein’s binding capabilities. To investigate this question, researchers in the Diss lab analyzed the effects of all possible mutations in a single protein across its interactions with an entire family of partner proteins. They focused on a protein called JUN, which plays a key role in DNA binding and cellular communication.

Using an innovative approach, EMBL scientists uncovered key interactions between molecular machines, potentially opening new avenues for drug development.

Choosing a film for a movie night is always a battle. Now imagine if you could pick one that provided a window into some of the most fundamental biological processes that keep us alive. For the first time ever, researchers have captured a real-time molecular movie to show how two essential cellular processes – transcription and translation – interact with each other in bacteria.

Continue reading “World’s First ‘Molecular Movie’: Witness DNA Becoming Life’s Blueprint in Real-Time” »

In a significant advancement in the field of anti-counterfeiting technology, Professor Jiseok Lee and his research team in the School of Energy and Chemical Engineering at UNIST have developed a new hidden anti-counterfeiting technology, harnessing the unique properties of silver nanoparticles (AgNPs). The results are published in Advanced Materials.

“The technology we have developed holds significant promise in preventing the counterfeiting of valuable artworks and defense materials, particularly in scenarios where authenticity must be verified against potential piracy,” Professor Lee explained.

The team leveraged the inherent disadvantage of AgNPs, which tend to discolor upon exposure to UV light, to create a controlled color development process. By trapping silver nanoparticles within a polymer matrix, researchers can manipulate particle size and, consequently, the color emitted under UV light. Larger polymer nets yield silver nanoparticles that appear yellow, while smaller nets produce a red hue, allowing for precise control of the resultant colors based on ingredient combinations.

Physicists are getting closer to controlling single-molecule chemical reactions – could this shape the future of pharmaceutical research?

A groundbreaking study demonstrates control over atomic-level matter through nanotechnology. By leveraging the precision of scanning tunneling microscopy, researchers have shown how competing chemical reaction outcomes can be influenced by manipulating energy levels. This advancement allows for targeted reactions, such as those needed for drug synthesis, while reducing unwanted byproducts.

Continue reading “Breakthrough in Nanotechnology Unlocks Atomic Precision for Medicine and Energy” »

A new Science Advances study demonstrates a vaccine for cancer immunotherapy that would speed up the efficiency of messenger RNA translation in cytoplasm—and effectively inhibited tumor growth.

For the study, the researchers conducted microscopy analyses of a zircon grain obtained from Black Beauty, which builds off a 2022 study involving the same zircon grain where researchers found the grain had experienced being “shocked” from a meteorite impact long ago. For this latest study, the researchers found that the zircon grain contained unique evidence regarding past liquid water on the Red Planet.

“We used nano-scale geochemistry to detect elemental evidence of hot water on Mars 4.45 billion years ago,” said Dr. Aaron Cavosie, who is a senior lecturer in the School of Earth and Planetary Sciences at Curtin University and a co-author on the study. “Hydrothermal systems were essential for the development of life on Earth and our findings suggest Mars also had water, a key ingredient for habitable environments, during the earliest history of crust formation. Through nano-scale imaging and spectroscopy, the team identified element patterns in this unique zircon, including iron, aluminum, yttrium and sodium. These elements were added as the zircon formed 4.45 billion years ago, suggesting water was present during early Martian magmatic activity.”

A remarkable proof-of-concept project has successfully manufactured nanoscale diodes and transistors using a fast, cheap new production technique in which liquid metal is directed to self-assemble into precise 3D structures.

In a peer-reviewed study due to be released in the journal Materials Horizons, a North Carolina State University team outlined and demonstrated the new method using an alloy of indium, bismuth and tin, known as Field’s metal.

Continue reading “‘Self-assembling’ nano-electronics: Faster, cheaper, more reliable” »

Scientists developed a DNA-based molecular controller that autonomously directs the assembly and disassembly of molecular robots, a key approach with potential applications in medicine and nanotechnology.

What do motion detectors, self-driving cars, chemical analyzers and satellites have in common? They all contain detectors for infrared (IR) light. At their core and besides readout electronics, such detectors usually consist of a crystalline semiconductor material.

Such materials are challenging to manufacture: They often require extreme conditions, such as a very high temperature, and a lot of energy. Empa researchers are convinced that there is an easier way. A team led by Ivan Shorubalko from the Transport at the Nanoscale Interfaces laboratory is working on miniaturized IR detectors made of colloidal quantum dots.

The words “quantum dots” do not sound like an easy concept to most people. Shorubalko explains, “The properties of a material depend not only on its chemical composition, but also on its dimensions.” If you produce tiny particles of a certain material, they may have different properties than larger pieces of the very same material. This is due to quantum effects, hence the name “quantum dots.”