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Abstract: The mechanistic basis of chronic liver disease is still only partially understood

Harmeet Malhi & team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments:

The figure shows reduction within the high-fat,-fructose, and-cholesterol,-lipotoxicity-influenced enhancer (FFC-LIE) mouse groups compared with FFC-scramble controls.


Address correspondence to: Harmeet Malhi, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55,905, USA. Phone: 507.284.0686; Email: [email protected].

Reconfigurable platform slows lights for on-chip photonic engineering

Integrated circuits are the brains behind modern electronic devices like computers or smart phones. Traditionally, these circuits—also known as chips—rely on electricity to process data. In recent years, scientists have turned their attention to photonic chips, which perform similar tasks using light instead of electricity to improve speed and energy efficiency.

What If You Could Have a Real-Life Tamagotchi but with Bacteria?

The Tamagotchi craze started during the 1990s, with the original electronic toys. Years before our smartphone obsession, Tamagotchis were pixelated pets you carried around, often on a keychain. You had tiny rubber buttons and a miniature screen to feed, clean, and take care of your Tamagotchi. If you failed, you returned to a tiny digital tombstone.

In recent years, Tamagotchis have made an unlikely comeback. But now, a team of students at Northeastern University want to build something much more real.

SquidKid looks like a whimsical cartoon squid, but it’s actually a “bioreactor,” essentially a biological life support system. Inside it, floating in a special “broth”, are millions of real, living, glowing bacteria. The students who designed it are blunt.

Samsung launches its first multi-folding phone as competition from Chinese brands intensifies

Samsung Electronics’s Galaxy Z TriFold media day at Samsung Gangnam in Seoul, South Korea, on Dec. 2, 2025.

Anadolu | anadolu | getty images.

Samsung Electronics on Monday announced the launch of its first multi-folding smartphone as it races to keep pace with innovations from fast-moving rivals.

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