Lifeboat Foundation

In air-breathing vertebrates, the circulatory and pulmonary systems contain separate networks of channels that intertwine but do not intersect with each other. Recreating such structures within cell-compatible materials has been a major challenge; even a single vasculature system can be a burden to create. Grigoryan et al. show that natural and synthetic food dyes can be used as photoabsorbers that enable stereolithographic production of hydrogels containing intricate and functional vascular architectures. Using this approach, they demonstrate functional vascular topologies for studies of fluid mixers, valves, intervascular transport, nutrient delivery, and host engraftment.

Science, this issue p. 458

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.

Continue reading “Multivascular networks and functional intravascular topologies within biocompatible hydrogels” »

With the possibility of millions or an infinite number of problems automating everything will cause all things to be solved digitally into a simple math problem. The problems could essentially be hacked by shores algorithm or maybe a theory of everything like m theory or Stephen Hawking’s theory of everything. Maybe it is just as simple as a basic formula like Einstein created E=mc². Also like some mathematicians have theorized maybe just one line of code that solves everything.

Automation is a game-changer for modern problem-solving – enabling not only visibility to real-time operations but the ability to effectively project the impact of potential solutions into the future. As problem-solvers become more comfortable using the new tools available to them, companies will be able to effectively isolate (and avoid) the impact of problems to their operations and focus their resources on solving the underlying issues and enabling long-term success. Learn More here.

We all know that maths is really hard. So hard, in fact, that there’s literally a whole Wikipedia page dedicated to unsolved mathematical problems, despite some of the greatest minds in the world working on them around the clock.

But as Avery Thompson points out at Popular Mechanics, from the outset at least, some of these problems seem surprisingly simple — so simple, in fact, that anyone with some basic maths knowledge can understand them… including us. Unfortunately, it turns out that proving them is a little harder.

Inspired by Thompson’s list, we’ve come up with our own list of deceptively simple maths problems to frustrate (and hopefully inspire) you.

Continue reading “6 Deceptively Simple Maths Problems That No One Can Solve” »

Andrew Wiles’ proof of Fermat’s Last Theorem is a famous example. Pierre de Fermat claimed in 1637 – in the margin of a copy of “Arithmetica,” no less – to have solved the Diophantine equation xⁿ + yⁿ = zⁿ, but offered no justification. When Wiles proved it over 300 years later, mathematicians immediately took notice. If Wiles had developed a new idea that could solve Fermat, then what else could that idea do? Number theorists raced to understand Wiles’ methods, generalizing them and finding new consequences.

No single method exists that can solve all Diophantine equations. Instead, mathematicians cultivate various techniques, each suited for certain types of Diophantine problems but not others. So mathematicians classify these problems by their features or complexity, much like biologists might classify species by taxonomy.

Holograms are a staple in science fiction, but creating ones detailed enough to have serious applications in the real world has proved difficult. While scientists have been slowly pushing the field of holographic projection forward, they haven’t been able to overcome a problem called cross-talk. However, in a recent paper published in Nature, they have been able to manipulate the shape of light to overcome this, thus allowing them to produce 3D holograms that are orders of magnitude clearer, larger, and more detailed.

What Are Holograms?

Simple holograms are 2D surfaces that produce the illusion of a 3D object when light is shined through it.

Continue reading “Solving a Math Problem Just Brought Holograms Closer to Reality” »

The multiplication of integers is a problem that has kept mathematicians busy since Antiquity. The “Babylonian” method we learn at school requires us to multiply each digit of the first number by each digit of the second one. But when both numbers have a billion digits each, that means a billion times a billion or 10¹⁸ operations.

At a rate of a billion operations per second, it would take a computer a little over 30 years to finish the job. In 1971, the mathematicians Schönhage and Strassen discovered a quicker way, cutting calculation time down to about 30 seconds on a modern laptop. In their article, they also predicted that another algorithm—yet to be found—could do an even faster job. Joris van der Hoeven, a CNRS researcher from the École Polytechnique Computer Science Laboratory LIX, and David Harvey from the University of New South Wales (Australia) have found that algorithm.

They present their work in a new article that is available to the scientific community through the online HAL archive. But one problem raised by Schönhage et Strassen remains to be solved: proving that no quicker method exists. This poses a new challenge for theoretical computer science.

Continue reading “A faster method for multiplying very big numbers” »

High-performance computing (HPC)—the use of supercomputers and parallel processing techniques to solve large computational problems—is of great use in the scientific community. For example, scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory rely on HPC to analyze the data they collect at the large-scale experimental facilities on site and to model complex processes that would be too expensive or impossible to demonstrate experimentally.

Modern science applications, such as simulating particle interactions, often require a combination of aggregated computing power, high-speed networks for data transfer, large amounts of memory, and high-capacity storage capabilities. Advances in HPC hardware and software are needed to meet these requirements. Computer and computational scientists and mathematicians in Brookhaven Lab’s Computational Science Initiative (CSI) are collaborating with physicists, biologists, and other domain scientists to understand their data analysis needs and provide solutions to accelerate the scientific discovery process.

Gravitational echoes may be caused by the collision of two black holes, and may indicate that these objects have completely new physical properties. This conclusion was made by RUDN physicists after a series of mathematical calculations. The scientists state that if the existence of the echo phenomenon is confirmed, astrophysicists would have to reconsider their view of compact space objects. The results of the study were published in Physical Review D.

According to the theory of general relativity (GR), any massive object distorts space-time. A similar effect is observed when a heavy metal ball is placed on stretched elastic fabric. The heavier is the ball, the deeper is the depression in the fabric. Similarly, the higher the mass of an object, the more it distorts space-time. Black holes are among the heaviest objects in the universe, and therefore distort space-time the most. When two black holes collide, gravitational waves spread out from the site of collision. They can be compared to rings on the water, or sound waves, but there is one important peculiar feature. Gravitational waves do not propagate spatially—they are themselves the oscillations of space-time.

Gravitational waves from the collision of two black holes decay with time, but on their final stage, they can cause the so-called echo—additional wave scattering. It can be compared to regular acoustic echo. The existence of such gravitational echo has not been confirmed yet, and there are different opinions about its possible source. A RUDN physicist, together with colleagues from the Czech Republic and Russia, assumed that if the existence of gravitational echo is experimentally confirmed, it would be the beginning of the new physics adding to GR.

Continue reading “Gravitational echo phenomenon will become a key to the new physics, physicist says” »

Mathematicians have confirmed that humanity’s collective attention span is getting shorter. And it’s not just social media that’s to blame.

Research reveals ‘social acceleration’ occurring across different domains. Samantha Page reports.