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BARDA is part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services.

The NTxscribe platform is a cell-free, continuous flow manufacturing system that reportedly delivers scalable RNA (including mRNA and self-amplifying RNA) materials in a tabletop footprint. This enzymatic process is designed to provide a low cost and rapidly deployable, vertically integrated manufacturing system, according to Jamie Coffin, PhD, CEO of NTx. Through this program, the system is being evaluated for its express development of RNA vaccines and therapeutics for infectious diseases, as well as its capability for distributed biomanufacturing.

“The traditional batch processes for developing vaccines and other biologics are burdensome and cannot be scaled quickly in the event of an emergency,” said Coffin. “Over the course of this project, we will aim to prove that NTxscribe can help BARDA meet its goals toward decentralized and rapidly deployable vaccine manufacturing.”

There are several perfectly good reasons why water isn’t a popular medium for calligraphers to write in. Constantly shifting and swirling, it doesn’t take long for ink to diffuse and flow out of formation.

An ingenious ‘pen’ developed by the researchers from Johannes Gutenberg University Mainz (JGU) and the Technical University of Darmstadt in Germany, and Huazhong University of Science and Technology in China, could give artists a whole new medium to work with.

The new device is a tiny, 50 micron-wide bead made of a special material that exchanges ions in the liquid, creating zones of relatively low pH. Traces of particles suspended in the water are then drawn to the acidic solution. Drawing out that zone can create persistent, ‘written’ lines.

Prepare to be awestruck by the incredible technological advancements on the horizon! Explore the mind-blowing innovations coming in the next 10 years.
#brightside.

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An active supermassive black hole is one of the greatest wonders in the cosmos.

A dense, invisible object that can be billions of times the mass of our Sun is surrounded by a vast, churning disk and torus of material, blazing with light as it swirls down onto the black hole center. But how big do these structures grow?

For the first time, an unambiguous detection of near-infrared light reveals the outskirts of the massive accretion disk surrounding a supermassive black hole hundreds of millions times our Sun’s mass, in a galaxy called III Zw 002 some 1.17 billion light-years away.

In a study published in Matter, researchers led by Prof. Yang Zhaorong and Prof. Hao Ning from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences found that the quasi-one-dimensional charge density wave (CDW) material cupric telluride (CuTe) provides a rare and promising platform for the study of multiple CDW orders and superconductivity under high pressure.

The interplay between superconductivity and CDW has always been one of the central issues in the research of condensed matter physics. While theory generally predicts that they compete with each other, superconductivity and CDW can manifest under external stimuli in practical materials. Additionally, recent research in the superconducting cuprates and the Kagome CsV3Sb5 has found that superconductivity interacts with multiple CDW orders. However, in the above two systems, there are some other quantum orders in the phase diagrams, which hinders a good understanding of the interplay between superconductivity and multiple CDWs.

In this study, the researchers provided solid evidence for a second CDW order in the quasi-one-dimensional CDW material CuTe under . In addition, they found that superconductivity can be induced and that it has complex relationships with the native and emergent CDW orders.

To assist humans during their day-to-day activities and successfully complete domestic chores, robots should be able to effectively manipulate the objects we use every day, including utensils and cleaning equipment. Some objects, however, are difficult to grasp and handle for robotic hands, due to their shape, flexibility, or other characteristics.

These objects include textile-based cloths, which are commonly used by humans to clean surfaces, polish windows, glass or mirrors, and even mop the floors. These are all tasks that could be potentially completed by robots, yet before this can happen robots will need to be able to grab and manipulate cloths.

Researchers at ETH Zurich recently introduced a new computational technique to create of crumpled cloths, which could in turn help to plan effective strategies for robots to grasp cloths and use them when completing tasks. This technique, introduced in a paper pre-published on arXiv, was found to generalize well across cloths with different physical properties, and of different shapes, sizes and materials.

Not all of the material around us is stable. Some materials may undergo radioactive decay to form more stable isotopes. Scientists have now observed a new decay mode for the first time. In this decay, a lighter form of oxygen, oxygen-13 (with eight protons and five neutrons), decays by breaking into three helium nuclei (an atom without the surrounding electrons), a proton, and a positron (the antimatter version of an electron).

Scientists observed this decay by watching a single nucleus break apart and measuring the breakup products. The study is published in the journal Physical Review Letters.

Scientists have previously observed interesting modes of following the process called beta-plus decay. This is where a proton turns into a neutron and emits some of the produced energy by emitting a positron and an antineutrino. After this initial beta-decay, the resulting nucleus can have enough energy to boil off extra particles and make itself more stable.

A study recently published in the journal Nanophotonics reveals that by rapidly modulating the refractive index – which is the ratio of the speed of electromagnetic radiation in a medium compared to its speed in a vacuum – it’s possible to produce photonic time crystals (PTCs) in the near-visible part of the spectrum.

The study’s authors suggest that the ability to sustain PTCs in the optical domain could have profound implications for the science of light, enabling truly disruptive applications in the future.

PTCs, materials in which the refractive index rises and falls rapidly in time, are the temporal equivalent of photonic crystals in which the refractive index oscillates periodically in space causing, for example, the iridescence of precious minerals and insect wings.