A new study reveals young blood, specifically from bone marrow cells, can rejuvenate aging human skin.
Category: life extension – Page 9
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline
Persistent genomic instability compromises cellular viability while also triggers non-cell-autonomous responses that drive dysfunction across tissues, contributing to aging. Recent evidence suggests that DNA damage activates secretory programs, including the release of inflammatory cytokines, damage-associated molecular patterns, and extracellular vesicles, that reshape immune homeostasis, stem cell function, and metabolic balance. Although these responses may initially support tissue integrity and organismal survival, their chronic activation has been associated with tissue degenerative changes and systemic decline. Here, we discuss how nuclear DNA damage responses trigger the activation of cytoplasmic sensing pathways, promote secretory phenotypes, and affect organismal physiology. Targeting DNA damage-driven mechanisms may help buffer harmful systemic responses while preserving regeneration and immune surveillance, offering new ways to delay aging-related decline.
© 2025 The Author(s). BioEssays published by Wiley‐VCH GmbH.
Systemic factors in young human serum influence
Aging is a complex process that significantly contributes to age-related diseases and poses significant challenges for effective interventions, with few holistic anti-aging approaches successfully reversing its signs. Heterochronic parabiosis studies illuminated the potential for rejuvenation through blood-borne factors, yet the specific drivers including underlying mechanisms remain largely unknown and until today insights have not been successfully translated to humans. In this study, we were able to recreate rejuvenation of the human skin via systemic factors using a microphysiological system including a 3D skin model and a 3D bone marrow model. Addition of young human serum in comparison to aged human serum resulted in an improvement of proliferation and a reduction of the biological age as measured by methylation-based age clocks in the skin tissue. Interestingly, this effect was only visible in the presence of bone marrow-derived cells. Further investigation of the bone marrow model revealed changes in the cell population in response to young versus aged human serum treatment. Using proteome analysis, we identified 55 potential systemic rejuvenating proteins produced by bone marrow-derived cells. For seven of these proteins, we were able to verify a rejuvenating effect on human skin cells using hallmarks of aging assays, supporting their role as systemic factors rejuvenating human skin tissue.
Aging | doi:10.18632/aging.206288. Johanna Ritter, Cassandra Falckenhayn, Minyue Qi, Leonie Gather, Daniel Gutjahr, Johannes Schmidt, Stefan Simm, Stefan Kalkhof, Janosch Hildebrand, Thomas Bosch, Marc Winnefeld, Elke Grönniger, Annette Siracusa.
“SuperAgers” Show Cognitive Decline Is Not an Inevitable Part of Aging
For 25 years, scientists at Northwestern Medicine have been studying people aged 80 years and older – dubbed “SuperAgers” – to uncover what makes them stand out.
In a new study, researchers show that these individuals display memory performance comparable to those at least 30 years younger, defying the long-held belief that cognitive decline is an unavoidable part of aging.
The study was published in Alzheimer’s & Dementia.
EnsembleAge: enhancing epigenetic age assessment with a multi-clock framework
Several widely used epigenetic clocks have been developed for mice and other species, but a persistent challenge remains: different mouse clocks often yield inconsistent results. To address this limitation in robustness, we present EnsembleAge, a suite of ensemble-based epigenetic clocks. Leveraging data from over 200 perturbation experiments across multiple tissues, EnsembleAge integrates predictions from multiple penalized models. Empirical evaluations demonstrate that EnsembleAge outperforms existing clocks in detecting both pro-aging and rejuvenating interventions. Furthermore, we introduce EnsembleAge HumanMouse, an extension that enables cross-species analyses, facilitating translational research between mouse models and human studies. Together, these advances underscore the potential of EnsembleAge as a robust tool for identifying and validating interventions that modulate biological aging.
Humans Could Live For 1,000 Years by 2050—Ushering in the Dawn of ‘Practical Immortality,’ Futurists Say
Some experts warn that this radical change may remain out of reach for many, due to societal and economic challenges.
Lifestyle and environmental factors affect health and ageing more
A new study led by researchers from Oxford Population Health has shown that a range of environmental factors, including lifestyle (smoking and physical activity) and living conditions, have a greater impact on health and premature death than our genes.
The researchers used data from nearly half a million UK Biobank participants to assess the influence of 164 environmental factors and genetic risk scores for 22 major diseases on ageing, age-related diseases, and premature death. The study is published in Nature Medicine.
Pelage Pharmaceuticals Announces Positive Phase 2a Clinical Trial Results for PP405 in Regenerative Hair Loss Therapy
Clinical validation of stem cell reactivation approach positions Pelage as leader in regenerative medicine and aging
LOS ANGELES—(BUSINESS WIRE)— #HairLoss —Pelage Pharmaceuticals, a clinical-stage regenerative medicine company, today announced positive results from its Phase 2a clinical trial of PP405 — a topical therapy for androgenetic alopecia advancing through the FDA clinical development pathway. PP405 is designed to reactivate dormant hair follicle stem cells, offering a potential first-in-class approach for both men and women experiencing hair loss.
In a world breakthrough, Israeli researchers grow first long-term human kidney in lab
In a world first, researchers from Sheba Medical Center and Tel Aviv University have successfully grown human kidney organoids – a synthetic 3D organ culture – using kidney tissue stem cells.
The synthetic kidney organs matured and stayed stable for 34 weeks, which is the longest-lasting and purest set of kidney organoids ever developed.
Prof. Benjamin Dekel, Director of the Pediatric Nephrology Unit and the Stem Cell Research Institute at the Safra Children’s Hospital at Sheba Medical Center and Director of the Sagol Center for Regenerative Medicine at Tel Aviv University led the study. Doctoral student Dr. Michael Namestannikov, a graduate of the Physician-Researcher track at Tel Aviv University’s Faculty of Medicine, and Dr. Osnat Cohen-Sontag, a research associate at Sheba Medical Center, participated in the research.