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Archive for the ‘life extension’ category: Page 8

Sep 4, 2020

Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy

Posted by in categories: biotech/medical, life extension, nanotechnology

Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL.

Keywords: Bee venom, Melittin, Melittin conjugates, Cancer management, Anti-cancer effects.

Cancer is one of the major ailment effecting humankind and remains as one of the leading causes of mortality worldwide. The current available data suggests that over 10 million new patients are diagnosed with the disease every year and over 6 million deaths are associated with it representing roughly 12% of worldwide deaths. Fifteen million new cancer cases are anticipated to be diagnosed in the year 2020 [1] which will potentially increase to over 20 million by 2025 [2] and more in years to come. It is also anticipated that the growth and aging of the population may increase the new cancer cases to 21.7 million with about 13 million cancer deaths by the year 2030 [3].

Sep 3, 2020

This Drug Makes Mice Live Longer and Healthier Lives

Posted by in categories: biotech/medical, life extension

The Buck Institute for Research on Aging scientists behind the research found that female mice that were fed enough AKG to maintain a younger mouse’s blood levels of the compound lived eight to 20 percent longer than the control group, according to research published Tuesday in the journal Cell Metabolism. On top of that, male and female mice who ate AKG had better fur color, stronger grips, and improved gait compared to others.

There’s a long and bumpy road between a successful mouse experiment and any sort of clinical applications for humans, but scientists are encouraged because AKG is already considered safe for humans to take.

“The big thing about this is that its safety profile is so good,” Holly Brown-Borg, a University of North Carolina aging researcher who didn’t work on the study told Science Magazine. “It has potential and should be explored further, for sure.”

Sep 3, 2020

Feeding the World with Cellular Aquaculture: Food Security and Sustainability

Posted by in categories: bioengineering, biotech/medical, chemistry, life extension

Cellular Aquaculture — Feed The World and Save the Oceans — Lou Cooperhouse, President & CEO, of BlueNalu, joins me on ideaXme (https://radioideaxme.com/) to discuss his company’s technologies to provide the world with healthy and safe cell-based seafood products, and support the sustainability and diversity of our oceans — #Ideaxme #StemCells #Aquaculture #Oceans #Fish #Sushi #Poke #Ceviche #SustainableDevelopment #Agriculture #Health #Wellness #RegenerativeMedicine #Biotech #Longevity #Aging #IraPastor #Bioquark #Regenerage ideaXme BlueNalu Rutgers University Rich Products Sumitomo Chemical: Group Companies of the Americas KBW Investments.


Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Lou Cooperhouse, President and CEO of BlueNalu.

Continue reading “Feeding the World with Cellular Aquaculture: Food Security and Sustainability” »

Sep 3, 2020

Tom Lawry Talks of Machine Learning and Microsoft AI For Good in Healthcare

Posted by in categories: biotech/medical, life extension, robotics/AI

Deploying “AI for Good” In The Life Sciences — Tom Lawry, National Director for Artificial Intelligence, Health & Life Sciences, Microsoft, joins me on ideaXme to discuss how they are deploying artificial intelligence “at scale”, across the major organizations responsible for delivery quality, next generation healthcare to millions of patients and customers — #Ideaxme #Microsoft #ArtificialIntelligence #MachineLearning #DeepLearning #Health #Healthcare #Wellness #Medicine #Pharmacy #Hospitals #Nursing #Insurance #Diagnostics #Data #Moonshots #Biotechnology #Longevity #LifeExtension #Aging #IraPastor #Bioquark #Regenerage


Ira Pastor, ideaXme life sciences ambassador, interviews Tom Lawry, National Director for Artificial Intelligence — Health & Life Sciences at Microsoft.

Continue reading “Tom Lawry Talks of Machine Learning and Microsoft AI For Good in Healthcare” »

Sep 3, 2020

Dr Christine Moutier talks of Mental Health Awareness, Suicide Prevention and Building Resilience

Posted by in categories: biotech/medical, life extension, neuroscience

Worldwide, 800,000 people die annually due to suicide (1 every 40 seconds) — There are more than twice as many suicides as homicides — Suicide is now the 10th leading cause of death in the US, and the 2nd leading cause of death among individuals between ages of 10 and 34 — Dr. Christine Moutier, M.D., Chief Medical Officer, American Foundation for Suicide Prevention, joins me on ideaXme to discuss her organization’s work in suicide prevention science and impacting these disturbing trends — #Ideaxme #Suicide #Depression #MentalHealth #Psychiatry #Anxiety #Stress #Trauma #Coronavirus #Burnout #WellBeing #Resilience #Health #Wellness #Longevity #Aging #IraPastor #Bioquark #Regenerage National Institute of Mental Health National Academy of Medicine.


Ira Pastor, ideaXme life sciences ambassador and founder of Bioquark, interviews Dr. Christine Moutier, MD, Chief Medical Officer, at the American Foundation for Suicide Prevention (AFSP).

Continue reading “Dr Christine Moutier talks of Mental Health Awareness, Suicide Prevention and Building Resilience” »

Sep 3, 2020

Watch: This video is narrated in Spanish, my native language, but I added comprehensive subtitles in English

Posted by in categories: internet, life extension, transhumanism

Actually, the predominant language of the website is English, but even me being bilingual, I felt more comfortable delivering the narrative in my native language.

In the video, I give a thorough overview of the content and organization of my website Transhumanplus.com. It has a huge amount of information, growing constantly, on the transhumanist movement, emerging technologies in general, and very specially, on the longevity, rejuvenation and life extension field.

Continue reading “Watch: This video is narrated in Spanish, my native language, but I added comprehensive subtitles in English” »

Sep 2, 2020

Billionaires Pour US $400 Million into Initiatives to Help the Weak and Vulnerable

Posted by in category: life extension

US$400 million for healthy aging and elder care.


Ira Pastor ideaXme life sciences ambassador interviews Shelley Lyford, President and Chief Executive Officer of West Health, the Gary and Mary West Foundation, and the West Health Institute.

Continue reading “Billionaires Pour US $400 Million into Initiatives to Help the Weak and Vulnerable” »

Sep 1, 2020

Bodybuilding supplement promotes healthy aging and extends life span, at least in mice

Posted by in category: life extension

Alpha-ketoglutarate could be safer than other potential anti-aging treatments.

Sep 1, 2020

VRK-1 Protein Activation Increased Lifespan of Worms

Posted by in categories: biotech/medical, life extension, nanotechnology, robotics/AI, singularity

Brian Wang is a Futurist Thought Leader and a popular Science blogger with 1 million readers per month. His blog Nextbigfuture.com is ranked #1 Science News Blog. It covers many disruptive technology and trends including Space, Robotics, Artificial Intelligence, Medicine, Anti-aging Biotechnology, and Nanotechnology.

Known for identifying cutting edge technologies, he is currently a Co-Founder of a startup and fundraiser for high potential early-stage companies. He is the Head of Research for Allocations for deep technology investments and an Angel Investor at Space Angels.

A frequent speaker at corporations, he has been a TEDx speaker, a Singularity University speaker and guest at numerous interviews for radio and podcasts. He is open to public speaking and advising engagements.

Continue reading “VRK-1 Protein Activation Increased Lifespan of Worms” »

Sep 1, 2020

A naturally-occurring metabolite ups lifespan and compresses late-life morbidity in mice

Posted by in categories: biotech/medical, life extension

Middle-aged mice that had the naturally-occurring metabolite alpha-ketaglutarate (AKG) added to their chow had a better “old age.” They were healthier as they aged and experienced a dramatically shorter time of disease and disability before they died, a first for research involving mammals. Results from the double-blinded study, published in Cell Metabolism, were based on clinically-relevant markers of healthspan.

Previous studies show that blood plasma levels of AKG can drop up to 10-fold as we age. Fasting and exercise, already shown to promote longevity, increase the production of AKG is not found in the normal diet, making supplementation the only feasible way to restore its levels.

“The standard for efficacy in research on aging is whether interventions actually improve healthspan. We’ve reached that mark here with a compound that is naturally produced by the body and is generally shown to be safe,” said Buck professor and senior author Gordon Lithgow, Ph.D… Noting that some of the mice did experience moderate lifespan extension (the average was around 12%), measures of healthspan increased more than 40 percent. Lithgow says the goal is always to compress the time of disease and frailty. “The nightmare scenario has always been life extension with no reduction in disability. In this study, the treated middle-aged mice got healthier over time. Even the mice that died early saw improvements in their health, which was really surprising and encouraging.”

Continue reading “A naturally-occurring metabolite ups lifespan and compresses late-life morbidity in mice” »

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