Lifeboat Foundation

Most of us who’ve reached middle age have noticed a slowing in memory and cognition, but scientists don’t have a clear picture of the molecular changes that take place in the brain to cause it.

Now, a study in mice has determined that the most pronounced changes occur in the white matter, a type of nervous system tissue that’s integral to transmitting signals across the brain. The study also examined two treatments — caloric restriction and infusions of plasma from young mice — that affect certain regions of the brain, with the plasma appearing to slow the age-related decline.

Continue reading “Stanford Medicine-led research identifies gene ‘fingerprint’ for brain aging” »

The “chemical cocktail” helped reverse aging in mice, but some experts are skeptical about whether it will work in humans.

Imagine walking on a treadmill and time is the speed at which the belt moves. As you age, the speed of the belt increases, representing time passing faster and faster as we age. However, what if we could speed up and run faster than the belt? This is widely known as the concept of Longevity Escape Velocity (LEV), which is essentially the idea of outrunning time itself.

Longevity Escape Velocity refers to a future scenario in which medical progress and innovation allows scientists to extend human lifespan at a rate greater than the passage of time. Imagine a world where each passing year not only adds another year to our lives but also enhances our health, vitality, and functional abilities. This concept, popularised by Biomedical gerontologist Dr. Aubrey de Grey, centres around the idea of developing rejuvenation therapies that repair age-related damage at the cellular and molecular levels, with the aim of effectively reversing the aging process.

Organisations such as Dr Aubrey de Grey’s LEV Foundation are playing a huge role in attempting to achieve this extraordinary milestone by striving to speed up the development of life extending therapies and endeavouring to make them accessible to all. It can be argued that they tend to focus on high risk, high reward research that other institutions might overlook due to its experimental nature, however without those that dare to think big, developments in longevity science will not make the strides needed to make a real impact in our future.

It turns out that an amino acid that our body produces may play a huge role in longevity. Here’s what scientists say about taurine.

An injection of a specific blood factor can replicate exercise’s brain benefits, offering potential treatments for age-related cognitive decline.

Pre-clinical trials by University of Queensland scientists have found that an injection of a specific blood factor can replicate the benefits of exercise in the brain.

Dr. Odette Leiter and Dr. Tara Walker from UQ’s Queensland Brain Institute led a team that discovered platelets, the tiny blood cells critical for blood clotting, secrete a protein that rejuvenates neurons in aged mice in a similar way to physical exercise.

How would it feel to control objects with your mind? Or hear colors? Or maybe even live forever? Well, if you want to find out, all you have to do is become a cyborg. How would being part machine affect us? Would it cause a greater divide between the rich and the poor? And is this the next step in human evolution?

Transcript and sources: https://whatifshow.com/what-if-we-become-cyborgs/

Continue reading “What If We Became Cyborgs?” »

Transhumanism — advocates strongly for humans to develop and make widely available sophisticated technologies that enhance human physiology and intellect greatly. In layman’s terms, transhumanists would like for human beings to become cyborgs; cybernetic organisms.

As such, transhumanist concepts feature greatly in science fiction. Cyborgs are commonly seen in all forms of science fiction media…

Continue reading “Transhumanism: Will Humans Become Cyborgs?” »

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This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.