Archive for the ‘life extension’ category: Page 7

Aug 16, 2021

The Role of Alpha-Ketoglutaric Acid (AKG) in Longevity and Healthy Aging

Posted by in category: life extension

Alpha-ketoglutarate is a good example of a much more science-based substance to impact aging. But only using AKG is not enough to significantly slow down the aging process. There are many reasons why we age, and AKG can also address only a few of them, in a very specific way.

Note: Since I’m leaving on vacation tomorrow (Yellowstone baby!), we’ve got a special guest post for you this week from Dr. Kris Verburgh and the fine folks at Novos Labs; a longevity supplement startup targeting multiple aging hallmarks with different life-extending compounds. They’ve been featured on Longevity. Technology and also have a fantastic blog we’ll link to below that’s worth checking out. Since our next content block will be all about different anti-aging supplements and the science behind them, we thought this overview of Alpha-Ketoglutaric Acid (AKG) for longevity would serve as a nice teaser for when we finish up diet and nutrition in October and switch over. So without further ado, take it away, Kris!

In the last few years, we have seen the rise of more science-based supplements to slow down aging.

Continue reading “The Role of Alpha-Ketoglutaric Acid (AKG) in Longevity and Healthy Aging” »

Aug 16, 2021

Beyond grateful that my dog Milo was accepted into the Dog Aging Project after being rejected 18 months ago!

Posted by in category: life extension

This April, the Dog Aging Project and Colorado State University began a $23 million dollar undertaking studying aging in dogs.

They are looking for more canine volunteers so if this is something that interests you head on over to their website to nominate your furry friends!… See More.

Aug 16, 2021

The march towards ever-expanding human longevity marks another achievement with the successful transplant of a fully-functional artificial heart!

Posted by in categories: biotech/medical, life extension

If you needed a heart transplant or suffered from cardiovascular disease, would you consider replacing your biological heart for an artificial one? How many of you with healthy hearts would want the transplant?

Aug 16, 2021

Scientists successfully reversed age-related memory loss in mice

Posted by in category: life extension

Aug 13, 2021

Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Posted by in categories: biotech/medical, genetics, life extension, neuroscience

Yes this says a 3 year epigenetic clock reversal in just 8 weeks thanks to diet and lifestyle changes. There is a list of supplements too:

Alpha ketoglutarate, vitamin C and vitamin A curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin.

Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50–72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. The control group received no intervention. Genome-wide DNA methylation analysis was conducted on saliva samples using the Illumina Methylation Epic Array and DNAmAge was calculated using the online Horvath DNAmAge clock (2013). The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (−25%, p=0.009). To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males. Larger-scale and longer duration clinical trials are needed to confirm these findings, as well as investigation in other human populations.

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Aug 13, 2021

A Specific Example of How AlphaFold 2 From DeepMind Could Help Us Achieve Immortality

Posted by in categories: biotech/medical, life extension, robotics/AI

I think SENS did this last year but now AlphaFold2 will make it easier and faster.

Hey it’s Han from WrySci HX discussing how breakthroughs in the protein folding problem by AlphaFold 2 from DeepMind could combine with the SENS research foundation’s approach of allotopic mitochondrial gene expression to fight aging damage. More below ↓↓↓

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Aug 12, 2021

Aged skeletal stem cells interfere with healing and promote ‘inflamm-aging’

Posted by in categories: biotech/medical, life extension

Researchers at the Stanford Institute for Stem Cell Biology and Regenerative Medicine have discovered how changes in aging skeletal stem cells may be an underlying cause of poor fracture healing, osteoporosis and various blood disorders as well as generalized inflammation and aging (sometimes called “inflamm-aging”) of cells and systems throughout the body. However, the researchers are also discovering how they might reinvigorate aging skeletal stem cell so that they start acting younger again, potentially reversing these changes.

“Skeletal stem give rise to bone, cartilage, and special cells that provide a niche or nursery for blood and to develop,” said Charles Chan, PhD, a member of the institute and an assistant professor in the Department of Surgery, Plastic and Reconstructive Surgery, and Immunology. “So if aged skeletal stem cells are not performing well, they can contribute to a wide variety of the disorders that we find in older people.”

The Research was published in the journal Nature. Chan and professor Michael Longaker, MD, are senior authors on the paper. Longaker is the Dean P. and Louise Mitchell Professor in the School of Medicine and a member of the Institute for Stem Cell Biology and Regenerative Medicine. Postdoctoral fellow Thomas Ambrosi, PhD is a co-first author along with former medical student Owen Marecic, MD and former postdoctoral fellow Adrian McArdle, MD, PhD.

Aug 12, 2021

New blood: Lab-grown stem cells bode well for transplants, aging research

Posted by in categories: biotech/medical, life extension

Hematopoietic stem cells—the precursors to blood cells—have been notoriously difficult to grow in a dish, a critical tool in basic research. Scientists at University of California San Diego School of Medicine have identified the underlying issue and developed a method to keep cultured cells healthy. These findings, they say, are positive news for patients seeking stem cell transplants—and may hint at a new way to ward off aging.

The findings will be published in the August 12 2021 online issue of Cell Stem Cell.

In transplants, hematopoietic stem are infused intravenously to reestablish blood production in patients whose bone marrow or is damaged. The procedure is used to treat diseases such as leukemia, lymphoma, aplastic anemia and immune deficiency disorders. However, are not always available for patients who need them.

Aug 11, 2021

This 1,992 paper was included on best-selling CDR World Philosophy compilation (before internet) and I claim some credit for circulated it and popularising the “Transhuman sidetrack”

Posted by in categories: chemistry, cryonics, ethics, existential risks, law, life extension, robotics/AI, transhumanism

Since 1,988 and formation of the Posthuman Movement, and articles by early adopters like Max Moore were a sign our message was being received — although I always argued on various Extropian & Transhuman bulletin boards & Yahoo groups &c that “Trans” was a redundant middle and we should move straight to Posthuman, now armed with the new MVT knowledge (also figures on the CDR). There will be a new edition of World Philosophy, the first this millennium, to coincided with various Posthuman University events later this year. Here is the text:


Max More Executive Director, Extropy Institute.

Continue reading “This 1,992 paper was included on best-selling CDR World Philosophy compilation (before internet) and I claim some credit for circulated it and popularising the ‘Transhuman sidetrack’” »

Aug 10, 2021

Scientists Reversed Aging in Mouse Brains With Poo Transplants From Young Mice

Posted by in categories: biotech/medical, food, life extension, neuroscience

Evidence has been accumulating for almost a decade that the microbiome composition changes with age. In 2,012 research by my colleagues at University College Cork showed that diversity in the microbiome was linked to health outcomes in later life, including frailty.

In 1,895 on turning 50 Elie Metchnikoff became increasingly anxious about aging. As a result, the Russian Nobel prize-winning scientist, and one of the founders of immunology, turned his attention away from immunology and towards gerontology – a term that he coined.

He was fascinated by the role that intestinal bacteria play in health and disease and suggested that people from parts of eastern Europe lived longer because they ate a lot of fermented foods containing lactic acid bacteria.

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