Lifeboat Foundation

I have mentioned mTOR as one of the main aging genes on multiple occasions. It’s about time I tell you what it is, what it does and why it is so important in aging.

mTOR has a little m in front of TOR, which means I am speaking about mammals. It technically means «mechanistic» TOR, but think of it as the molecule that mice and all of us have, whereas in worms is it just TOR.

mTOR gene produces one mTOR protein that can act in two pretty different ways. mTOR does so, because it forms two complexes with other molecules. These complexes are called mTORC1 and mTORC2. Yeah, I know, it’s a lot of letters, but C1 and C2 stand for «complex 1» and «complex 2», so it kinda makes sense.

Continue reading “The mTOR Story Part 1 — What Makes This Important Pro-Aging Molecule Active?” »

“When resources are scarce, a species as a whole has a better shot at surviving if its populations are organizing themselves to promote long term survival with shorter individual lifespans. They are evolving to combat overpopulation and overconsumption, basically…humans could be living a lot longer than they do now—we have, after all, inherited a lifespan from times when our forebears were eking out an existence as scrappy hunter gatherers” Read more

Something amazing has happened! We have launched our Longevity Cookbook Indiegogo Campaign.

Aging steals away your most valuable resource: time. The Longevity Cookbook is a strategy guide to help you get more time to experience the joy from everything that you like in life. Take yourself on a journey starting with nutrients and exercise regimes that goes on to exploring the usage of genetically modified symbiotic organisms and using gene therapy to boost your own longevity.

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A team of Massachusetts General Hospital (MGH) investigators has made the first steps towards development of bioartificial replacement limbs suitable for transplantation They had used decellularization technique to regenerate kidneys, livers, hearts and lungs from animal models, but this is the first reported use to engineer the more complex tissues of a bioartificial limb.

They took the leg from recently deceased rat and then:

* Over a period of 52 hours, infusion of a detergent solution removes cells from a rat forelimb, leaving behind the cell-free matrix scaffolding onto which new tissues can be regenerated.

Continue reading “Next Big Future: Conceptually Viable Brute Force Radical Life Extension” »

Curing aging has 4 stages: mild aging deceleration, dramatic aging deceleration, achieving negligible senescence and rejuvenation. Today we can definitively claim that the task of mild aging deceleration is theoretically solved.

We know the drugs and interventions that slow down aging in mammals. The only thing that we don’t know is dosages, regimes and drug combinations. Defining all of that is the goal of pre-clinical and clinical studies. They can be started immediately. It is also a good idea to do clinical studies of various diets aimed at improving human longevity.

Dramatic aging deceleration will be achieved using gene therapy. Breakthrough studies of lifespan extension in old model animals happened in this area quite recently. We know the genes and delivery methods, now we need a set of powerful experiments aimed at radical life extension. The subject of the intervention will not only be the human genome, but the genomes of the human microbiota.

Continue reading “Fours Stages of Curing Aging” »

A long interview from Esquire on transhumanism, AI, life extension, my campaign, and thoughts on the future.

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New story in The Huffington Post on transhumanism, life extension, and overcoming deathist culture:

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“The Howard Hughes Medical Institute (HHMI) announced today that 26 of the nation’s top biomedical researchers will become HHMI investigators and will receive the flexible support necessary to move their research in creative new directions. The initiative represents an investment in basic biomedical research of $153 million over the next five years.”

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Harnessing “Black Holes”: The Large Hadron Collider – Ultimate Weapon of Mass Destruction

Why the LHC must be shut down