Lifeboat Foundation

Very huge step forward for brain sensory mapping.

Data from functional magnetic resonance imaging (fMRI) have provided eye-popping pictures of the way the brain is wired, and allowed neuroscientists and laypeople alike to view intricate anatomical and functional connections between regions of the brain. But what if a new tool could be applied to MRI and other data, to listen to the way the brain works and how it is forged with connections?

An emerging effort to “sonify” imaging data is taking root at UT Dallas’ Center for Vital Longevity, in the lab of Dr. Gagan Wig. The approach, now funded by the Defense Advanced Research Projects Agency (DARPA), allows data to be represented by sounds from which a trained listener might be able to discern patterns of brain connectivity not readily seen in available visualization strategies.

Continue reading “Collaborative Minds Bringing Sounds to Brain Data in Yearlong Project” »

Unity Biotechnology today announced that it is developing medicines to treat and eliminate age-related diseases and increase healthspan, or the amount of time an individual lives in good health.

BrewLife on behalf of Unity Biotechnology.

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For the first time, scientists have shown that mitochondria — the “powerhouses” of cells — are crucial for aging, after finding that removing mitochondria from human cells reduced levels of markers for cellular aging, triggering a process of rejuvenation.

More info: http://ow.ly/Y5CcB

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A study of cadavers reveals a dramatic decrease of vitamin B12 in the brain across the ages but also among young people with autism and schizophrenia.

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Post-Human

Radically often it seems like something out of science fiction. But every day that passes we get closer to the technological singularity.

Visit: http://www.awarenessalgorithm.com/ ~ The awakening of the future …

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A rabbit’s brain has been successfully returned from long-term cryogenic storage, marking the first time a whole mammalian brain has been recovered in near-perfect condition.

It marks a significant breakthrough in the field of cryonics and boosts the prospect of one day bringing frozen human brains back to life.

Researchers from 21st Century Medicine (21CM) used a new technique called Aldehyde-stabilized cryopreservation that filled the vascular system of the rabbit brain with chemicals that would allow it to be cooled to −211 degrees Fahrenheit (−135 degrees Celsius). When it was thawed, the cell membranes, synapses, and intracellular structures remained intact.

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Researchers from 21st Century Medicine have developed a new technique to allow long term storage of a near-perfect mammalian brain. It’s a breakthrough that could have serious implications for cryonics, and the futuristic prospect of bringing the frozen dead back to life.

By using a chemical compound to turn a rabbit’s brain into a near glass-like state, and then cooling it to −211 degrees Fahrenheit (−135 degrees Celsius), a research team from California-based 21st Century Medicine (21CM) showed that it’s possible to enable near-perfect, long-term structural preservation of an intact mammalian brain. The achievement has earned not just accolades from the scientific community, but a prestigious award as well; the 21CM researchers are today being awarded the $26,735 Small Mammal Brain Preservation Prize, which is run by the Brain Preservation Foundation (BPF).

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The Brain Preservation Foundation (BPF) announced that the Small Mammal Brain Preservation Prize has officially been won. The spectacular result achieved by 21st Century Medicine researchers provides the first demonstration that near-perfect, long-term structural preservation of an intact mammalian brain is achievable.

A team from 21st Century Medicine, spearheaded by recent MIT graduate Robert McIntyre, has discovered a way to preserve the delicate neural circuits of an intact rabbit brain for very long-term storage using a combination of chemical fixation and cryogenic cooling. Proof of this accomplishment, and the full “Aldehyde-Stabilized Cryopreservation” (ASC) protocol, was recently published in the journal Cryobiology and has been independently verified by the BPF through extensive electron microscopic examination conducted by the two official judges of the prize: BPF President Ken Hayworth and Princeton neuroscience professor Sebastian Seung, author of “Connectome: How the Brain’s Wiring Makes Us Who We Are.”

“Every neuron and synapse looks beautifully preserved across the entire brain,” said Hayworth. “Simply amazing given that I held in my hand this very same brain when it was frozen solid… This is not your father’s cryonics.”

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Researchers at Sanford Burnham Prebys Medical Research Institute (SBP) have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle. The discovery clears up deep-rooted conflicting data and will now help streamline efforts towards boosting stem cell-mediated muscle regeneration. Such strategies could treat muscle degenerative diseases such as muscular dystrophies, and those associated with aging and cancer.

The research, published today in eLife, describes the essential role of a TBP-containing TFIID-protein complex in activating genes that regenerate muscle tissue, and shows that an alternative protein called TBP2 is not involved in this task in adult muscles.

“Our discovery clarifies the identity of the ‘molecular switches’ that control the activation of muscle genes in muscle stem cells (MuSCs),” said Barbora Malecova, Ph.D., postdoctoral fellow in the laboratory of Pier Lorenzo Puri, M.D., professor in the Development, Aging and Regeneration Program at SBP, and first author of the article. “Understanding what drives muscle gene expression gives us insights into molecular targets for regenerative medicine-based interventions (drugs) to treat muscle degenerative disorders.”

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