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Archive for the ‘life extension’ category: Page 545

Aug 4, 2017

Transforming T Cells to Regulate the Immune System

Posted by in categories: biotech/medical, life extension

An interesting new study has demonstrated a method to reprogram specific T cells. Much like researchers have been experimenting recently with macrophages and making them change into an anti-inflammatory rather than a proinflammatory type, the team here has achieved similar results with T cells.

As we age the immune system becomes dysfunctional, either due to immune cells become overactive and creating too much inflammation or by cells that suppress the immune system such as senescent cells that inhibit cell function.

A dysfunctional immune system leaves us vulnerable to diseases and chronic levels of inflammation from excessive immune responses prevent tissue regeneration and wound healing. The researchers here have discovered how to target pro-inflammatory T cells that increase the immune response and inflammation and change them into anti-inflammatory cells that suppress the immune response, and vice versa.

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Aug 2, 2017

Scientists Prove That Cryogenically Frozen Life Can Be Reanimated

Posted by in category: life extension

Research on cryogenically frozen zebrafish embryos shows that they can continue developing once they’re thawed.

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Aug 2, 2017

Can we, as adults, grow new neurons? YES: Sandrine Thuret

Posted by in categories: biotech/medical, life extension, robotics/AI

Can we, as adults, grow new neurons? Neuroscientist Sandrine Thuret with a background in food science, molecular, cellular, behavioural and ageing biology says that we can, and she offers research and practical advice on how we can help our brains better perform neurogenesis—improving mood, increasing memory formation and preventing the decline associated with aging along the way.

“Can we, as adults, grow new nerve cells? There’s still some confusion about that question, as this is a fairly new field of research. For example, I was talking to one of my colleagues, Robert, who is an oncologist, and he was telling me, “Sandrine, this is puzzling. Some of my patients that have been told they are cured of their cancer still develop symptoms of depression.” And I responded to him, “Well, from my point of view that makes sense. The drug you give to your patients that stops the cancer cells multiplying also stops the newborn neurons being generated in their brain.” And then Robert looked at me like I was crazy and said, “But Sandrine, these are adult patients — adults do not grow new nerve cells.” And much to his surprise, I said, “Well actually, we do.” And this is a phenomenon that we call neurogenesis.”

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Aug 2, 2017

We Should Be Optimistic But Not Complacent About Progress

Posted by in categories: biotech/medical, education, life extension

In the last year or so we have seen remarkable progress with a number of interventions that target the aging processes to prevent and treat age-related diseases.

Senescent cell clearance has enjoyed lots of media attention and is entering human clinical trials later this year with Unity Biotechnology. We have LysoClear from Ichor Therapeutics moving towards the clinic with a therapy based on the LysoSENS approach advocated for by the SENS Research Foundation, which seeks to treat age-related blindness caused by the accumulation of waste products in the retina cells of patients. Dr. David Sinclair is moving into human trials this year with a therapy aimed at repairing DNA damage, one of the main reasons we are thought to age.

We have had amazing progress in immunotherapy, where the immune system is taught to detect cancer and other diseases far more efficiently. For instance, immunotherapy has been used to allow the immune system spot cancer that uses the same “Do not eat me” signals that healthy cells use to avoid destruction.

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Aug 2, 2017

Get the stylish da Vinci Vitruvian Man T-shirt and put the sexy into science, plus you get a cool sticker and button

Posted by in categories: life extension, science

https://www.lifespan.io/campaigns/agemeter-biomarker-scan/#reward_4

The ultimate bundle for those who want the world to see that they support science. This is just one of the fantastic rewards available in the AgeMeter campaign on Lifespan.io, support science today and make da Vinci proud!

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Aug 1, 2017

Professor George Church – Turning Back Time to End Age-related Diseases

Posted by in categories: bioengineering, biotech/medical, computing, genetics, life extension, neuroscience

Many of you will likely already know who Professor George Church is and that he is an important and senior member of the research community engaged in treating the aging processes to prevent or reverse age-related diseases, not to mention all kinds of other applications for genetic engineering. For those who are not familiar with him a short bio follows.

George Church is a professor at Harvard & MIT, the co-author of over 425 papers, 95 patent publications and the book Regenesis. He developed the methods used for the first genome sequence back in 1994 and he was instrumental in reducing the costs since then using next generation sequencing and nanopores plus barcoding, DNA assembly from chips, genome editing, writing and re-coding.

He co-initiated the Genome projects in 1984 and 2005 to create and interpret the world’s only open-access personal precision medicine datasets. He was also involved in launching the BRAIN Initiative in 2011.

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Aug 1, 2017

Exponential Artificial Intelligence Can Immortalize Human

Posted by in categories: biological, life extension, Ray Kurzweil, robotics/AI

https://youtube.com/watch?v=Uc99zH0GqfE

Ray Kurzweil, one of the world’s leading inventors, thinkers, and futurists, with a thirty-year track record of accurate predictions and called “the restless genius” by The Wall Street Journal and “the ultimate thinking machine” by Forbes magazine, spoke at the Nobel Week Dialogue in Gothenburg, Sweden.

In this talk, Kurzweil explores the history and trajectory of exponential advances in computing and Information Technology to project how he believes Artificial Intelligence (AI) may enhance our natural biological intelligence in the future.

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Jul 31, 2017

New Stem Cell Therapy Could Help Treat Osteoporosis and Restore Bones

Posted by in categories: biotech/medical, life extension, space

For every month in space, astronauts can lose 2.5 percent of their bone density. This is quite troublesome, as it will likely compound with the natural process of aging that also reduces bone density. However, a new therapy could be a fantastic solution to this issue, along with many other bone-weakening conditions.

Researchers from University College London have discovered that stem cells found in human amniotic fluid could be used in a treatment to strengthen brittle bones. The research, published in Scientific Reports, shows the treatment resulted in 79 percent fewer fractures in mice with brittle bone disease. Out of a total 324 mice, 168 were treated, while 156 served as the control group. Eight weeks after the mice were treated both the test group and the control group were evaluated for fractures.

Every control mouse exhibited fractures. Conversely, fractures in the experimental group decreased between 69 and 89 percent, leading to the 79 percent decrease in the fracture rate across all tested bones. Pascale Guillot, the study leader, found that the treatment was not resulting in new bone formation, but instead helping to fortify existing bone tissue.

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Jul 31, 2017

Opinion: Super-intelligence and eternal life—transhumanism’s faithful follow it blindly into a future for the elite

Posted by in categories: bioengineering, biotech/medical, cyborgs, genetics, life extension, nanotechnology, robotics/AI, transhumanism

The rapid development of so-called NBIC technologies – nanotechnology, biotechnology, information technology and cognitive science – are giving rise to possibilities that have long been the domain of science fiction. Disease, ageing and even death are all human realities that these technologies seek to end.

They may enable us to enjoy greater “morphological freedom” – we could take on new forms through prosthetics or . Or advance our cognitive capacities. We could use brain-computer interfaces to link us to advanced artificial intelligence (AI).

Nanobots could roam our bloodstream to monitor our health and enhance our emotional propensities for joy, love or other emotions. Advances in one area often raise new possibilities in others, and this “convergence” may bring about radical changes to our world in the near-future.

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Jul 31, 2017

Rethinking Radical Thoughts: How Transhumanists Can Fix Democracy

Posted by in categories: business, economics, geopolitics, life extension, robotics/AI, transhumanism

O n a recent evening at a start-up hub in Spitalfields, London, journalist and author Jamie Bartlett spoke to a small group of mostly under 40, mainly techie or creative professionals about his book Radicals: Outsiders Changing the World. The book, which Bartlett started to research in 2014, before Brexit and Trump, chronicles his time with a series of different radical groups, from the Psychedelic Society — who advocate the “careful use of psychedelics as a tool for awakening to the unity and interconnectedness of all things” — to Tommy Robinson, co-founder of the unabashedly far-right English Defence League, to the founder of Liberland, a libertarian nation on unclaimed land on the Serbian/Croatian border, to Zoltan Istvan, who ran as US transhumanist presidential candidate on a platform of putting an end to death. He campaigned by racing around America in a superannuated RV which he’d modified to look like a giant coffin, dubbed “the Immortality Bus.” His efforts were in vain, and illegal, as it turned out: his campaign was in breach of the US’ Federal Electoral Commission rules.

Bartlett’s book has been damned with faint praise — he has been called “surprisingly naive about politics,” and defining ‘radical’ so broadly as to make the term “meaningless.” The general consensus goes that Bartlett’s journey through the farthest-flung fringes of politics and society is entertaining and impressively dispassionate, but not altogether successful in making a clear or convincing case for radicals or radicalism. But at the talk that night Bartlett challenged what he sees as the complacent acceptance and defense of our current political and governmental systems, institutions and ideas, of the kind of technocratic centrism that prevailed throughout the global North until very recently. Perhaps they need some radical rethinking. Many of the radicals Bartlett spent time with may be flawed, crazy or wrong — literally, legally and morally — but they can also hold up mirrors and magnifying glasses to political and social trends. And sometimes, they can prophesize them…

Bartlett began the evening by saying, “If democracy were a business, it would be bankrupt.” A provocative statement, but one that he backs up. He pointed to research showing that only 30% of those born after 1980 believe that it is essential to live in a democracy. That rate drops steadily with age. A closer look at the research around peoples’ attitudes reveals widespread skepticism towards liberal institutions and a growing disaffection with political parties. Freedom House’s annual report for 2016 shows that as faith in democracy has declined so too have global freedoms — 2016 marks the “11th consecutive year of decline in global freedom.” While a lot of attention has been given to violent polarization, populism and nationalism rising out of anger at demographic and economic changes, Bartlett suggests that perhaps comfort and complacency are culprits too, and he is not the only one: only last week Financial Times columnist Janan Ganesh took up a similar theme.

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